Sergio Scaccianoce

Sex-Dependent Modulation of AMPA and GABA A Receptors in Response to Perinatal Stress: Implications for Cognitive and Emotion-related Behaviors

Alessandra Gaetano, Vance Difan Gao, Gilles Van Camp, Hammou Bouwalerh et autres

Background: Early-life stress can severely impact brain health and neuronal plasticity, potentially leading to psychiatric disorders, with excitatory and inhibitory neurotransmission changes being key to understanding and mitigating these effects. Objective: We investigated the effects of Perinatal Stress (PRS) on the balance …

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Corticotropin-Releasing Hormone: Biology and Therapeutic Opportunities

Alessandra J. Caruso, Alessandra Gaetano, Sergio Scaccianoce

In 1981, Wylie Vale, Joachim Spiess, Catherine Rivier, and Jean Rivier reported on the characterization of a 41-amino-acid peptide from ovine hypothalamic extracts with high potency and intrinsic activity stimulating the secretion of adrenocorticotropic hormone and β-endorphin by cultured anterior pituitary cells. …

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Postweaning social isolation and autism-like phenotype: A biochemical and behavioral comparative analysis

Alessandra J. Caruso, Laura Ricceri, Angela Caruso, Ferdinando Nicoletti et autres

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Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress

Paola Colucci, Alessia Santori, Luca Romanelli, Clemens Zwergel et autres

Amphetamine is a potent psychostimulant that increases brain monoamine levels. Extensive evidence demonstrated that norepinephrine is crucially involved in the regulation of memory consolidation for stressful experiences. Here, we investigated amphetamine effects on the consolidation of long-term recognition memory in rats exposed …

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Postweaning Social Isolation and Autism-Like Phenotype: A Biochemical and Behavioral Comparative Analysis

Alessandra J. Caruso, Laura Ricceri, Angela Caruso, Ferdinando Nicoletti et autres

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Risk Factors for Alzheimer’s Disease: Focus on Stress

Alessandra J. Caruso, Ferdinando Nicoletti, Alessandra Gaetano, Sergio Scaccianoce

In vulnerable individuals, chronic and persistent stress is an established risk factor for disorders that are comorbid with Alzheimer's disease (AD), such as hypertension, obesity and metabolic syndrome, and psychiatric disorders. There are no disease-modifying drugs in the treatment of AD, and …

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In Vivo Microbial Targeting of 99mTc-Labeled Human β-Defensin-3 in a Rat Model of Infection

Giulia Anna Follacchio, Alessandro Pala, Sergio Scaccianoce, Francesco Monteleone et autres

OBJECTIVE: Differentiation of infection from aseptic inflammation represents a major clinical issue. None of the commercially available compounds (labeled granulocytes, antigranulocyte antibodies, Ga-citrate, labeled immunoglobulin G, F-FDG) is capable of this differentiation, producing a nonnegligible false-positive rate. Recently, our group reported on …

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The positive allosteric modulator at mGlu2 receptors, LY487379, reverses the effects of chronic stress‐induced behavioral maladaptation and synaptic dysfunction in the adulthood

Dalila Mango, Alessandra J. Caruso, Amira Saidi, Robert Nisticò et autres

Chronic stress induces maladaptive neural responses in several brain areas including hippocampus. It has been demonstrated that chronic stress exposure induced a downregulation of the putative presynaptic type 2 metabotropic glutamate (mGlu2) receptors, which would reduce the negative feedback role exerted by …

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Stress as risk factor for Alzheimer’s disease

Alessandra J. Caruso, Ferdinando Nicoletti, Dalila Mango, Amira Saidi et autres

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Morphine Withdrawal Modifies Prion Protein Expression in Rat Hippocampus

Vincenzo Mattei, Stefano Martellucci, Francesca Santilli, Valeria Manganelli et autres

The hippocampus is a vulnerable brain structure susceptible to damage during aging and chronic stress. Repeated exposure to opioids may alter the brain so that it functions normally when the drugs are present, thus, a prolonged withdrawal might lead to homeostatic changes …

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Music, Spatial Task Performance, and Brain Plasticity in Elderly Adults

Maria Tecla Pecci, Walter Verrusio, Antonio Francesco Radicioni, Antonella Anzuini et autres

The effect of music by Mozart on cognitive performance and brain plasticity in elderly adults was explored. To the knowledge of the authors, this is the first study to provide documentary evidence of an increase in brain-derived neurotropic factor (BDNF) serum levels …

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Increased Total Urinary Cortisol (tUC) and Serum Brain-derived Neurotrophic Factor (BDNF) Ratio in Alzheimer Disease (AD)-affected Patients

Martina Curto, Antonio Martocchia, Stefano Ferracuti, Fabrizia Comite et autres

no abstract available

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