Zhijiu Zhong

Highly expressed STING in liver metastasis of uveal melanoma can lead to synergistic killing

Zhijiu Zhong, Qing Liu, Mizue Terai, Sergei Koshkin et autres

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Abstract 6849: Tumor microenvironment gene expression dynamics: Keystone cell types and non-cancer cell driver genes.

Yongzhong Zhao, Yixiao Cui, Ji Zheng, Cody Stevens et autres

Abstract Cancer is not a disease, rather, of multi-scale heterogeneity, i.e., each victim of cancer is of unique evolutionary dynamics at distinct levels. Indeed, cancer therapeutics has been evolving from non-specific chemo and radiation therapy, mutation-specific targeted therapy, immunotherapy, as well as …

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PPARγ acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding

Lifeng Tian, Xuanmao Jiao, Chenguang Wang, Danni Li et autres

Peroxisome proliferator-activated receptor γ (PPARγ), which is expressed in a variety of malignancies, governs biological functions through transcriptional programs. Defining the molecular mechanisms governing the selection of canonical versus non-canonical PPARγ binding sequences may provide the opportunity to design regulators with distinct …

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Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute toLMNAcardiomyopathy

Kunal Sikder, Elizabeth Phillips, Zhijiu Zhong, Nadan Wang et autres

Mutations in theLMNAgene encoding lamins A/C cause an array of tissue-selective diseases, with the heart being the most commonly affected organ. Despite progress in understanding the perturbations emanating fromLMNAmutations, an integrative understanding of the pathogenesis underlying cardiac dysfunction remains elusive. Using a …

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Abstract 3582: PPAR gamma acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding

Lifeng Tian, Xuanmao Jiao, Chenguang Wang, Adam Ertel et autres

Abstract Background: HER2/neu overexpression in breast cancer confers a lipogenic phenotype. Although the introduction of anti-Her2 therapies has led to dramatic improvements in survival, nearly all patients with metastatic Her2-positive breast cancer will progress on treatment suggesting the importance of developing coextinction …

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Data from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Zhijiu Zhong, Wen-Shuz Yeow, Chunhua Zou, Richard Wassell et autres

Abstract Cyclin D1 belongs to a family of proteins that regulate progression through the G1-S phase of the cell cycle by binding to cyclin-dependent kinase (cdk)-4 to phosphorylate the retinoblastoma protein and release E2F transcription factors for progression through cell cycle. Several …

Supplementary Figure 1 from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Zhijiu Zhong, Wen-Shuz Yeow, Chunhua Zou, Richard Wassell et autres

Supplementary Figure 1 from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Supplementary Methods and Materials, Figure Legend from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Zhijiu Zhong, Wen-Shuz Yeow, Chunhua Zou, Richard Wassell et autres

Supplementary Methods and Materials, Figure Legend from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Supplementary Methods and Materials, Figure Legend from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Zhijiu Zhong, Wen-Shuz Yeow, Chunhua Zou, Richard Wassell et autres

Supplementary Methods and Materials, Figure Legend from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Supplementary Figure 1 from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Zhijiu Zhong, Wen-Shuz Yeow, Chunhua Zou, Richard Wassell et autres

Supplementary Figure 1 from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Data from Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells

Zhijiu Zhong, Wen-Shuz Yeow, Chunhua Zou, Richard Wassell et autres

Abstract Cyclin D1 belongs to a family of proteins that regulate progression through the G1-S phase of the cell cycle by binding to cyclin-dependent kinase (cdk)-4 to phosphorylate the retinoblastoma protein and release E2F transcription factors for progression through cell cycle. Several …

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy

Kunal Sikder, Elizabeth Phillips, Zhijiu Zhong, Nadan Wang et autres

Abstract Mutations in the LMNA gene encoding nuclear lamins A/C cause a diverse array of tissue-selective diseases, with the heart being the most commonly affected organ. Despite progress in understanding the molecular perturbations emanating from LMNA mutations, an integrative understanding of the …

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