Lindsey Chudley

Identification of pre-existing ubiquitous neoantigen-reactive tumor-infiltrating T-cells in a patient with metastatic pancreatic neuroendocrine tumor

Jean‐Benoit Tanis, Katy J. McCann, Francisco Emmanuel Castañeda-Castro, Jaya Thomas et autres

ABSTRACT Background Mutation-derived neoantigens, typically identified in primary tumors, are emerging therapeutic targets for personalized cancer vaccines and adoptive T-cell therapies. However, clinical efficacy of neoantigen-directed therapies in patients with metastatic disease remains limited, partly due to inter-site genetic heterogeneity. We investigated …

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Tissue-resident immune cells drive genetic risk in autoimmune and lung diseases

Benjamin Joachim Schmiedel, Cristian González-Colín, Vicente Fajardo, J. Hernández et autres

Common genetic variants are associated with risk of lung and autoimmune diseases. However, we have a limited understanding of the pathological effects of these disease variants, specifically in tissue-resident immune cells at the frontier of infection and disease in the lung. To …

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Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens

Vicente Fajardo, Aquib Ehtram, Isabel Marchand-Casas, Serena J. Chee et autres

Lung tissue-resident memory T (TRM) cells are critical for frontline immunity, yet they undergo rapid attrition in the mouse lung. Whether this paradigm applies to humans has remained unknown. Here we present a comprehensive analysis of T cells from human lungs, characterizing …

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177P Ubiquitous neoantigens as targets for T cell recognition in a patient with metastatic pancreatic neuroendocrine tumour

Jean‐Benoit Tanis, Katy J. McCann, Eduardo Castañeda-Saucedo, James Thomas et autres

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999MO HARE-40: A phase I/II trial of therapeutic HPV vaccine (BNT113) in patients with HPV16 driven carcinoma

C.H.H. Ottensmeier, Elizabeth A. King, S. Crabb, Ioannis Karydis et autres

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Data from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes

Katy J. McCann, Ann Mander, Angelica M. Cazaly, Lindsey Chudley et autres

Abstract Purpose: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201–binding peptide CAP-1 from carcinoembryonic antigen (CEA605–613) linked to an immunostimulatory domain (DOM) from fragment C of tetanus toxin. Experimental Design: Twenty-seven patients with CEA-expressing carcinomas were recruited: 15 …

Supplementary Figures 1-6, Supplementary Tables 1-2 from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes

Katy J. McCann, Ann Mander, Angelica M. Cazaly, Lindsey Chudley et autres

Supplementary Figure S1: Detection of CAP-1-specific T-cells Supplementary Figure S2: Effect of CAP-1-specific responses on OS Supplementary Figure S3: Effect of tumor load on vaccine-induced responses Supplementary Figure S4: Discovery of CAP-1-specific TCRs Supplementary Figure S5: Effect of diarrhea on OS Supplementary …

Supplementary Figures 1-6, Supplementary Tables 1-2 from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes

Katy J. McCann, Ann Mander, Angelica M. Cazaly, Lindsey Chudley et autres

Supplementary Figure S1: Detection of CAP-1-specific T-cells Supplementary Figure S2: Effect of CAP-1-specific responses on OS Supplementary Figure S3: Effect of tumor load on vaccine-induced responses Supplementary Figure S4: Discovery of CAP-1-specific TCRs Supplementary Figure S5: Effect of diarrhea on OS Supplementary …

Data from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes

Katy J. McCann, Ann Mander, Angelica M. Cazaly, Lindsey Chudley et autres

Abstract Purpose: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201–binding peptide CAP-1 from carcinoembryonic antigen (CEA605–613) linked to an immunostimulatory domain (DOM) from fragment C of tetanus toxin. Experimental Design: Twenty-seven patients with CEA-expressing carcinomas were recruited: 15 …

Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs

Simon Eschweiler, Ciro Ramírez-Suástegui, Yingcong Li, Emma Victoria King et autres

Abstract Phosphoinositide 3-kinase δ (PI3Kδ) has a key role in lymphocytes, and inhibitors that target this PI3K have been approved for treatment of B cell malignancies 1–3 . Although studies in mouse models of solid tumours have demonstrated that PI3Kδ inhibitors (PI3Kδi) …

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Correlation of HPV16 gene status and gene expression in OPSCC

Adrian von Witzleben, Eve Currall, Oliver Wood, Lindsey Chudley et autres

Introduction : Human Papillomavirus 16 (HPV16) can cause oropharyngeal squamous cell carcinoma (OPSCC). To assess the viral gene expression in primary cancer tissue we analysed the correlation of viral genomic and transcriptomic gene expression. Material and Methods : DNA and RNA were …

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Korrelation von HPV16 Genstatus und Genexpression in OPSCC

Adrian von Witzleben, Eve Currall, Oliver Wood, Lindsey Chudley et autres

Einleitung : Das humane Papillomavirus 16 (HPV16) kann oropharyngeale Plattenepithelkarzinome (OPSCC) verursachen. Um die virale Genexpression in primärem Krebsgewebe zu bewerten, analysierten wir die Korrelation zwischen viraler genomischer und transkriptomischer Genexpression. Material und Methoden : DNA und RNA wurde von 27 p16-positiven …

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