George M. Eng

Pancreatic cancer-associated organ dysfunction promotes muscle autophagy and contributes to peripheral tissue wasting

Yetiş Gültekin, Sharanya Sivanand, Kian Moritz Eghbalian, Anna M. Barbeau et autres

Abstract Normal pancreas function supports both digestion and the hormonal regulation of whole-body metabolism. We find pancreatic ductal adenocarcinoma (PDAC) disrupts the normal function of the remaining pancreas, leading to altered systemic metabolism and peripheral tissue wasting that begins early in disease …

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Correction: Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays

A. Khademhosseini, Judy Yeh, George M. Eng, Jeffrey M. Karp et autres

Correction for ‘Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays’ by Ali Khademhosseini et al. , Lab Chip , 2005, 5 , 1380–1386, https://doi.org/10.1039/B508096G.

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Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Constantine N. Tzouanas, Jessica E.S. Shay, Marc Samuel Sherman, Adam J. Rubin et autres

During chronic stress, cells must support both tissue function and their own survival. Hepatocytes perform metabolic, synthetic, and detoxification roles, but chronic nutrient imbalances can induce hepatocyte death and precipitate metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH). Despite prior work identifying stress-induced drivers …

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Abstract A045: Pancreatic cancer-associated systemic nutrient starvation elevates autophagic proteolysis in the muscle

Yetiş Gültekin, Sharanya Sivanand, Kian Moritz Eghbalian, Anna M. Barbeau et autres

Abstract The pancreas regulates whole-body metabolism through its exocrine and endocrine functions. In pancreatic ductal adenocarcinoma (PDAC), tumor-driven exocrine dysfunction contributes to systemic nutrient depletion, but its role in muscle wasting remains poorly understood. Using genetically engineered mouse models (GEMMs) of PDAC …

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Abstract C120: Spatial transcriptomic analysis of patient-derived explants identifies biomarkers of aggressive disease

Oliver von Richter, Elise G. DeArment, Kathryn Sun, Ramkrishna Mitra et autres

Abstract Prostate Cancer (PCa) is the most common non-cutaneous cancer and the second leading cause of cancer deaths in American men, with African American (AA) men experiencing higher PCa incidence and mortality rates than Caucasian American (CA) men. PCa development and progression …

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Corrigendum to ‘Layer-by-layer deposition of hyaluronic acid and poly-L-lysine for patterned cell co-cultures’ [Biomaterials 25 (2004) 3390]

Ali Khademhosseini, Kahp Yang Suh, Jen Ming Yang, George M. Eng et autres

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LGR5 as a diagnostic marker for dysplasia in serrated polyps

Osman H. Yilmaz, Kshitij Satnamdas Arora, S. Lee, Sahar Hosseini et autres

Aims WNT signalling pathway dysregulation is often a critical early component in colorectal neoplasia, particularly the chromosomal instability pathway. Using two WNT reporters, LGR5 and AXIN2, we sought to assess whether these polyps demonstrate predictable expression patterns and if these patterns show …

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An RNA damage response network mediates the lethality of 5-FU in colorectal cancer

Jung-Kuei Chen, Karl A. Merrick, Yi Wen Kong, Anita Izrael-Tomasevic et autres

5-fluorouracil (5-FU), a major anti-cancer therapeutic, is believed to function primarily by inhibiting thymidylate synthase, depleting deoxythymidine triphosphate (dTTP), and causing DNA damage. Here, we show that clinical combinations of 5-FU with oxaliplatin or irinotecan show no synergy in human colorectal cancer …

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SOX17 enables immune evasion of early colorectal adenomas and cancers

Norihiro Goto, Peter M.K. Westcott, Saori Goto, Shinya Imada et autres

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Germline Determinants of Esophageal Adenocarcinoma

Minyi Lee, George M. Eng, Anna Handte-Reinecker, Alvin Jeon et autres

The risk of progression for Barrett’s esophagus (BE) is estimated to range from 0.12% to 0.5% per year.1 Identification of clinical risk factors, such as age, sex, obesity, smoking, presence of hiatal hernia, and length of BE, are insufficient to wholly account …

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An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types

Jung-Kuei Chen, Karl A. Merrick, Yi Wen Kong, Anita Izrael-Tomasevic et autres

5-fluorouracil (5-FU) is a successful and broadly used anti-cancer therapeutic. A major mechanism of action of 5-FU is thought to be through thymidylate synthase (TYMS) inhibition resulting in dTTP depletion and activation of the DNA damage response. This suggests that 5-FU should …

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Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

Martin S. Taylor, Connie Wu, Peter C. Fridy, Stephanie J. Zhang et autres

Abstract Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring treatment response. While proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity for these applications. Long INterspersed Element-1 (LINE-1, L1) open reading frame 1 …

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