Luigi Sironi

The emerging role of microRNAs as targets of phytochemical intervention in myocardial infarction: a systematic review of in vitro and in vivo studies

Mirko Marino, Benedetta Mercuriali, Laura Castiglioni, Majeda Muluhie et autres

This systematic review evaluates the current literature on the protective mechanisms of dietary phytochemicals in cellular and animal models of myocardial infarction, with a specific focus on miRNA modulation. A literature search was conducted across three databases (PubMed, Scopus, and Embase) in …

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Achillea erba-rotta subsp. moschata (Wulfen) I. Richardson Modulates Inflammatory and Antioxidant Pathways in Brain Endothelial and Microglial Cells

Benedetta Mercuriali, Martina Bottoni, Fabrizia Milani, Majeda Muluhie et autres

Background. Neuroinflammation, driven by chronic microglial activation and blood–brain barrier dysfunction, is increasingly recognised as a key pathogenic mechanism in neurodegenerative disorders. Achillea erba-rotta subsp. moschata, an alpine medicinal plant traditionally employed for inflammatory conditions, has demonstrated antioxidant and anti-inflammatory properties; however, …

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Underlying pathophysiological mechanisms of aortic valve calcification: The role of PCSK9

Margaux Aize, Vincenza Valerio, Pascal Aumond, Laura Castiglioni et autres

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Arugula leaf nanovesicles as sustainable food ingredient: processing, stability, and bioavailability

Lorenza d’Adduzio, Davide Marangon, Umberto M. Musazzi, Giorgia Frigerio et autres

Plant-derived nanovesicles (PDVs) are emerging as natural nanostructures with potential applications in food and nutraceutical systems. In this study, we report the scalable production of arugula leaf–derived nanovesicles (ALVs) through ultrafiltration-size exclusion purification followed by spray-drying stabilization. This workflow ensured preservation of …

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Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC)

Simone Beretta, Mauro Tettamanti, Jacopo Mariani, Susanna Diamanti et autres

Background: Basic science studies have reported remote ischemic conditioning (RIC) as neuroprotective in acute ischemic stroke, although clinical evidence remains conflicting. The TRICS BASIC study (Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke) investigated the efficacy and safety of …

Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC)

Simone Beretta, Mauro Tettamanti, Jacopo Mariani, Susanna Diamanti et autres

BACKGROUND: Basic science studies have reported remote ischemic conditioning (RIC) as neuroprotective in acute ischemic stroke, although clinical evidence remains conflicting. The TRICS BASIC study (Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke) investigated the efficacy and safety of …

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Exploiting the 2-(1,3,4,9-tetrahydropyrano[3,4- b ]indol-1-yl)acetic Acid Scaffold to Generate COXTRANs: A New Class of Dual Cyclooxygenase Inhibitors-Thromboxane Receptor Antagonists

Federica Blua, Francesca Boccato, Carola Buccellati, Patrizia Risé et autres

Abstract The use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs) and coxibs is effective for the treatment of inflammatory pain and chronic inflammatory conditions. However, their use is associated with enhanced risk of cardiovascular toxicity and thrombotic events, particularly for the latter. The …

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Modulation of miRNAs by Phytochemicals in Cerebral Ischemia: A Systematic Review of In Vitro and In Vivo Studies

Joanna Rzemieniec, Mirko Marino, Benedetta Mercuriali, Laura Castiglioni et autres

Phytochemicals gained substantial interest for their protective action in cerebral ischemia. Additionally, there is a growing body of evidence suggesting that miRs play a role in stroke therapy. However, no systematic review to date has summarized the impact of phytochemicals on miRs …

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Multi-center Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC)

Simone Beretta, Mauro Tettamanti, Jacopo Mariani, Susanna Diamanti et autres

ABSTRACT Background Basic science studies have reported remote ischemic conditioning (RIC) as neuroprotective in acute ischemic stroke, while clinical evidence remains conflicting. The TRICS BASIC study investigated the efficacy and safety of RIC in experimental ischemic stroke using a rigorous clinical trial …

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Editorial: Brain-heart interactions in stroke

Benjamin Yong‐Qiang Tan, Luigi Sironi, Danesh Soltani, Ching-Hui Sia

Stroke is an important public health priority and is one of the leading causes of death and disability globally 1 . Increasingly, recent research has emphasized the intricate relationships between the brain and heart, revealing how cardiovascular and cerebrovascular health are interconnected …

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Involvement of proprotein convertase subtilisin/kexin type 9 in aortic valve calcification

Vincenza Valerio, Laura Castiglioni, Ilaria Massaiu, Pascal Aumond et autres

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Fenofibrate reduces cardiac remodeling by mitochondrial dynamics preservation in a renovascular model of cardiac hypertrophy

Laura Castiglioni, Paolo Gelosa, Majeda Muluhie, Benedetta Mercuriali et autres

Fenofibrate, a PPAR-α agonist clinically used to lower serum lipid levels, reduces cardiac remodeling and improves cardiac function. However, its mechanism of action is not completely elucidated. In this study we examined the effect of fenofibrate on mitochondria in a rat model …

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