Susan M. Bailey

The Impact of Dose, Sex, and Age at Time of Acute Whole-body Radiation Exposure on Long-term Hematopoiesis in Rhesus Macaques (Macaca mulatta)

Yuiko Chino, John D. Olson, Stephen Aichele, Susan M. Bailey et autres

The hematopoietic system is highly sensitive to ionizing radiation exposure. Accumulating evidence from the Japanese A-bomb survivor cohort and animal studies suggests that radiation-induced damage to the hematopoietic system can persist long after exposure, and therefore has the potential of contributing to …

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Dr. Bradford D. Loucas (1957–2025)

Michael N. Cornforth, Joel S. Bedford, Joseph R. Dynlacht, Michael D. Story et autres

Telomere length dynamics associated with short-duration human spaceflight

Bader Hamza Shirah, Eliah G. Overbey, Jonathan Foox, Jeremy Wain Hirschberg et autres

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Increased Reproductive Output and Telomere Shortening Following Calcium Supplementation in a Wild Songbird

Marina D. Rodriguez, Susan M. Bailey, Paul Francis Doherty, Kathryn P. Huyvaert

ABSTRACT Life history theory predicts increased parental investment comes with fitness costs, often expressed as negative effects on survival and future reproduction. To better understand the costs of reproduction and life history trade‐offs, we evaluated calcium supplementation at a high‐elevation site in …

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Results of a Biodosimetric re-assessment of Three Mile Island (TMI) exposures using whole genome directional genomic hybridization (dGH)

Doug Brugge, A. Datesman, Christopher J. Tompkins, Megan E. Rouillard et autres

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The Central Role of Cytogenetics in Radiation Biology

Susan M. Bailey, Stephen R. Kunkel, Joel S. Bedford, Michael N. Cornforth

Radiation cytogenetics has a rich history seldom appreciated by those outside the field. Early radiobiology was dominated by physics and biophysical concepts that borrowed heavily from the study of radiation-induced chromosome aberrations. From such studies, quantitative relationships between biological effect and changes …

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Even short trips to space can change an astronaut’s biology − a new set of studies offers the most comprehensive look at spaceflight health since NASA’s Twins Study

Susan M. Bailey

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The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Eliah G. Overbey, JangKeun Kim, Braden T. Tierney, Jiwoon Park et autres

Abstract Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space 1–6 . Yet current frameworks for aerospace medicine are nascent and lag …

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Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing

Taghreed M. Al-Turki, David G. Maranon, Christopher B. Nelson, Aidan M. Lewis et autres

Telomeres are repetitive nucleoprotein complexes at chromosomal termini essential for maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long noncoding RNA of heterogeneous lengths that contributes to end-capping structure and function, and facilitates telomeric recombination in tumors that maintain …

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A second space age spanning omics, platforms and medicine across orbits

Christopher E. Mason, James Green, Konstantinos I. Adamopoulos, Evan E. Afshin et autres

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Telomeres and aging: on and off the planet!

Christopher E. Mason, Maria A. Sierra, Henry J. Feng, Susan M. Bailey

Improving human healthspan in our rapidly aging population has never been more imperative. Telomeres, protective "caps" at the ends of linear chromosomes, are essential for maintaining genome stability of eukaryotic genomes. Due to their physical location and the "end-replication problem" first envisioned …

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Twins And Telomeres-In Space!

Susan M. Bailey

As part of the NASA Twins Study, our investigations related to telomeres and DNA damage responses (genome stability) during long-duration spaceflight have important implications for the health and performance of astronauts participating in exploration missions, as well as for long-term aging and …

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