S. I. Yum

Data-Driven Reduced-Order Modeling of Phase Mixing Dynamics from Particle Kinetic Simulation

Darian Figuera-Michal, S. I. Yum, Jae-Min Kwon, Eisung Yoon

Phase mixing is a fundamental kinetic process that governs dissipation and stability in collisionless plasmas, but its inherent filamentation in velocity space creates major challenges for both high-fidelity simulations and reduced-order modeling. This work presents the first exploratory evaluation of a joint …

Drug Delivery Systems Based on Diffusion and Osmosis

Rose M. Wright, S. I. Yum

The pharmaceutical community shows increasing interest in designing systems that will deliver a drug at a constant or near-constant rate. Various mechanisms can control the drug release rate. This chapter discusses control by the processes of diffusion or osmosis. Diffusional matrix systems …

185 TRANSDERMAL BUPIVACAINE FOR NEUROPATHIC PAIN: CLINICAL DEVELOPMENT PROGRESS

Dmitri Lissin, J Shah, M. Drass, Jeffrey S. Johnston et autres

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Drug Delivery Systems for the Treatment of Periodontal and Dental Diseases

Eric Yum, S. I. Yum

Capillary Blood Sampling for Self-Monitoring of Blood Glucose

S. I. Yum, Jeff Roe

New and emerging capillary blood sampling technologies for self-monitoring of blood glucose (SMBG) are reviewed for their impact on factors pertaining to users such as pain, and from the standpoint of skin physiology and technical feasibility. Innovative blood sampling techniques based on …

Systems for Triggered, Pulsed, and Programmed Drug Delivery

Felix Theeuwes, S. I. Yum, René Haak, Patrick S. L. Wong

DRUG DELIVERY AND THERAPEUTIC SYSTEMS

Felix Theeuwes, Peter Wong, S. I. Yum

Transdermal therapeutic systems and rate controlled drug delivery.

S. I. Yum

One of the key design features of transdermal therapeutic systems, namely the system rate-control, and its impact on systemic therapy, are reviewed. Specifically, TTS(scopolamine) and TTS(estradiol) are evaluated as examples of the rate-controlled transdermal products. The use of these TTS products has …

The osmotic pump: novel research tool for optimizing drug regimens

B. Eckenhoff, S. I. Yum

Development of Fluidized-Bed Spray Coating Process for Axisymmetrical Particles

S. I. Yum, J. B. Eckenhoff

A technique was developed for uniform, reproducible deposition of coating mateials on light-weight cylindrical particles, using the Wurster air-suspension coater. The particles used in this study had a length-to-diameter ratio of approximately four. Fluidization and coating characteristics were optimized by mixing the …

The Design of Controlled Drug Delivery Systems

Saravan Kumar Chandrasekaran, Felix Theeuwes, S. I. Yum

Inflation of Thin-Walled Elastic Tubes

S. I. Yum, Richard G. Buckles, Harold M. Leeper