Beth A. Winkelstein

Bridging Temporomandibular Joint Structure, Function, and Pain: An Integrated Multiscale Perspective

Peng Chen, Mildred C. Embree, Man‐Kyo Chung, Beth A. Winkelstein et autres

The temporomandibular joint (TMJ) features unique tissue structures that support its complex functional demands. Alterations in these structures are often linked to jaw dysfunction, with pain being one of the most prevalent symptoms. However, the mechanisms underlying TMJ pain and its relationship …

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Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future

John K. Neubert, Kyle D. Allen, Tamara N. Alliston, Alejandro J. Almarza et autres

Temporomandibular disorders (TMDs) are complex conditions characterized by orofacial pain and dysfunction, affecting a significant portion of the population. TMDs may involve joint and/or muscle pain, dysfunction (e.g., noise, limited or altered jaw movements), or both, leading to a marked decrease in …

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A Model to guide force-based manipulation research and practice

Mary Terry Loghmani, Damian Keter, Geoffrey M. Bove, Beth A. Winkelstein et autres

INTRODUCTION: Manual therapies are forms of force-based manipulations (FBM) and involve the application of mechanical force to the outside of the body with therapeutic intent. The United States National Institutes of Health (NIH) U24 FBM Taxonomy and Terminology Committee (FBM-TTC) was formed …

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Development and validation of a keypoint region-based convolutional neural network to automate thoracic Cobb angle measurements using whole-spine standing radiographs

Mert Marcel Dagli, Jaskeerat Gujral, Bhargavi R. Budihal, Marie Kerr et autres

PURPOSE: Adolescent idiopathic scoliosis (AIS) affects a significant portion of the adolescent population, leading to severe spinal deformities if untreated. Diagnosis, surgical planning, and assessment of outcomes are determined primarily by the Cobb angle on anteroposterior spinal radiographs. Screening for scoliosis enables …

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Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration

Qunzhou Zhang, Puhan He, Shihong Shi, Qilin Xu et autres

BACKGROUND: Accumulating evidence demonstrates that the therapeutic effects of stem cells are most likely attributed to their secretome, composed of a myriad of bioactive factors, including small extracellular vesicles (EVs). Due to the potential benefits over cells in term of handling, preservation, …

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Categorizing treatment mechanisms for Complementary and Integrative Musculoskeletal Interventions

Chad E. Cook, Victoria E. Abraira, John W. Burns, Brian F. Degenhardt et autres

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Manual therapy and exercise effects on inflammatory cytokines: a narrative overview

Chad E. Cook, Damian Keter, William Todd Cade, Beth A. Winkelstein et autres

Background: Matching disease and treatment mechanisms is a goal of the Precision Medicine Initiative. Pro- and anti-inflammatory cytokines (e.g., Tumor Necrosis Factor-alpha, Transforming Growth Factor-beta, and Interleukin-2, 10, and 12) have gained a significant amount of interest in their potential role in …

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Uniting disciplines for a modern take: exploring the science behind manual therapies

Victoria E. Abraira, Victor H. Barocas, Beth A. Winkelstein, Chad E. Cook

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Characterization of the L4/L5 rat facet capsular ligament macromechanical and microstructural responses to tensile failure loading

Sagar Singh, Beth A. Winkelstein

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Cervical facet capsular ligament mechanics: Estimations based on subject‐specific anatomy and kinematics

Maryam Nikpasand, Rebecca Abbott, Craig C. Kage, Sagar Singh et autres

Background: To understand the facet capsular ligament's (FCL) role in cervical spine mechanics, the interactions between the FCL and other spinal components must be examined. One approach is to develop a subject-specific finite element (FE) model of the lower cervical spine, simulating …

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Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading

Meagan E. Ita, Sagar Singh, Harrison R. Troche, Rachel L. Welch et autres

Chronic joint pain is a major healthcare challenge with a staggering socioeconomic burden. Pain from synovial joints is mediated by the innervated collagenous capsular ligament that surrounds the joint and encodes nociceptive signals. The interstitial collagenase MMP-1 is elevated in painful joint …

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MMPs Regulate Neuronal Substance P After a Painful Equibiaxial Stretch in a Co-Culture Collagen Gel Model Simulating Injury of an Innervated Ligament

Meagan E. Ita, Beth A. Winkelstein

Chronic joint pain is a major health problem that can result from abnormal loading of the innervated ligamentous capsule that surrounds synovial joints. The matrix metalloproteinases-1 (MMP-1) and MMP-9 are hypothesized pain mediators from stretch-induced injuries since they increase in pathologic joint …

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