Denise Syndercombe Court

Quo vadis, BGA? A collaborative EDNAP exercise on the challenges and progress in forensic biogeographical ancestry inference

Marta Diepenbroek, António Amorim, Katja Anslinger, Natasha Arora et autres

There is a broad consensus that forensic tests for the prediction of externally visible characteristics (EVC) and analysis of biogeographic ancestry (BGA) of an individual are technically reliable. However, interpretation of the results and population-specific genotype distribution patterns remains challenging. EVC and …

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Characterisation of the UK domestic dog (Canis lupus familiaris) population for identification purposes using a forensically validated set of 13 autosomal STR markers

Federica Giangasparo, David Ballard, Ryan Colligan, French Anderson et autres

correction of 0.2 when estimating direct match likelihood ratios from whole country allele frequency databases.

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Considerations for the Implementation of Massively Parallel Sequencing into Routine Kinship Analysis

Lucinda Davenport, Laurence Devesse, Somruetai Satmun, Denise Syndercombe Court et autres

Background: Investigating the way in which individuals are genetically related has been a long-standing application of forensic DNA typing. Whilst capillary electrophoresis (CE)-based STR analysis is likely to provide sufficient data to resolve regularly encountered paternity cases, its power to adequately resolve …

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DNA: Risks of Contamination to the Evidential Sample

Denise Syndercombe Court

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Forensic Serology—A Paradigm Shift

Denise Syndercombe Court

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Biogeographical Ancestry Estimation from Autosomal Short Tandem Repeats in the Sequencing Era

Laurence Devesse, Lucinda Davenport, Denise Syndercombe Court, David Ballard

Autosomal short tandem repeats (STRs) are, and likely always will be, the first loci targeted for forensic DNA analysis as they offer the highest probability of individual identification. An ancestry-informative marker panel can then be used in “no hit, no suspect” cases, …

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DNA Analysis in Forensic Investigations

Denise Syndercombe Court

Since Alec Jeffreys discovered minisatellites in the genome that could be used to produce a virtually unique DNA “fingerprint”, DNA technology has been used in civil and criminal justice settings to assist in questions of human identification, enabling perpetrators of crimes to …

Alec Samuels (1930–2022)

Denise Syndercombe Court

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Forensic identity SNPs: Characterisation of flanking region variation using massively parallel sequencing

Lucinda Davenport, Laurence Devesse, Denise Syndercombe Court, David Ballard

Single nucleotide polymorphisms (SNPs) can be analysed for identity or kinship applications in forensic genetics to either provide an adjunct to traditional STR typing or as a stand-alone approach. The advent of massively parallel sequencing technology (MPS) has provided a useful opportunity …

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A common epigenetic clock from childhood to old age

A. Freire-Aradas, Lorena Girón-Santamaría, Ana Mosquera‐Miguel, A. Ambroa-Conde et autres

Forensic age estimation is a DNA intelligence tool that forms an important part of Forensic DNA Phenotyping. Criminal cases with no suspects or with unsuccessful matches in searches on DNA databases; human identification analyses in mass disasters; anthropological studies or legal disputes; …

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Detection of a Novel Y-Chromosome Allele Variant for Locus DYS518

Federica Giangasparo, Sasitaran Iyavoo, Thomas Haizel, Laurence Devesse et autres

A rare allele 22 at marker DYS518 was detected during a wider population study of Y-chromosome short tandem repeat (STR) loci. The novel variant was discovered using the YFiler® Plus PCR Amplification kit and the sequence of the new allele confirmed with …

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Interpretation and reporting of mixed DNA profiles by seven forensic laboratories in the UK and Ireland

Ben Mallinder, S.J.A. Pope, J. A. Thomson, L A Beck et autres

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