Michael Chiu

Emergency department referral and short-term death after outpatient hyperkalemia: a population-based study

Michael Chiu, Danielle M. Nash, Graham Smith, Mohamed Abou El Hassan et autres

BACKGROUND: Hyperkalemia can be deadly, yet clinical decision-making for outpatient management is unclear. We sought to determine whether an emergency department encounter within 24 hours of a severe outpatient hyperkalemia result was associated with lower rates of immediate and short-term all-cause death. …

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Dual Invasive Fungal Infections After Kidney Transplantation: A Case Report

Layan Akkielah, Ahmed Bishara, Leigh J. Sowerby, John Johnson et autres

Donor-derived infections (DDIs), particularly fungal DDIs, are uncommon but serious complications of solid organ transplantation. We report a case of a 52-year-old woman who underwent deceased donor kidney transplantation complicated by probable donor-derived Candida albicans candidemia with native aortic valve endocarditis, managed …

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Obesity management for kidney TRANSPLANTation: protocol for the vanguard phase of an innovative randomised controlled trial, embedded in routine care (OK-TRANSPLANT 2)

Kristin K. Clemens, Jennifer Irwin, Michael Chiu, Stephanie Dixon et autres

Background Large randomised controlled trials (RCTs) of obesity interventions have excluded those with advanced chronic kidney disease (CKD) including recipients of dialysis. Obesity management is critically important to their health and healthcare, including their ability to access kidney transplant. Objective To describe …

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Weight-Management Services for Patients With Advanced Chronic Kidney Disease in Canada: A Survey of Nephrologists

Victoria Chechulina, Kristin K. Clemens, Amanda J. Vinson, Michael Chiu et autres

Background: Obesity and chronic kidney disease (CKD) often coexist and compound the risk of adverse health outcomes including dysglycemia and accelerated CKD progression. Obesity also limits access to kidney transplantation. The objectives of this study were to (1) understand current weight-management practices …

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Frequency, Management, and Outcomes of Outpatient Hyperkalemia: A Population-Based Cohort Study

Michael Chiu, Nivethika Jeyakumar, G. P. Smith, Danielle M. Nash et autres

Background: Hyperkalemia is a potentially life-threatening condition, with guidelines recommending urgent treatment when the serum potassium level is greater than 6.0 mmol/L. However, these recommendations are inconsistent, leading to diverse approaches to patient care. Objectives: The primary objectives were to use population-based …

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Combined Body Mass Index and Body Surface Area to Predict Post Kidney Transplant Outcomes in Patients With Obesity

Roxaneh Zaminpeyma, Louise Moist, Kristin K. Clemens, Michael Chiu et autres

Background. The prevalence of obesity is increasing in both the general and kidney failure populations. Severe obesity (body mass index [BMI] ≥ 40 kg/m2) is considered by many centers to be a barrier to kidney transplantation (KT). Obesity is typically defined using …

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Nonpharmacologic and Nonsurgical Weight Management Interventions for Patients With Advanced CKD: A Scoping Review of the Medical Literature

Kamel Omer, Kristin K. Clemens, Heather Lapier, Louise Moist et autres

Rationale & Objective: Obesity is associated with morbidity and mortality in people with chronic kidney disease (CKD). Identifying safe and effective nonpharmacologic and nonsurgical interventions to achieve a healthier body weight is essential. Study Design: Scoping review of observational studies and randomized …

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Implementation of a Kidney Genetic Service Into the Diagnostic Pathway for Patients With Chronic Kidney Disease in Canada

Clara Schott, Monica Arnaldi, Cadence Baker, Jian Wang et autres

Introduction: Genetic kidney disease (GKD) accounts for 10% to 20% of chronic kidney disease (CKD). Genetic testing using gene panel or targeted exome sequencing (ES) can confirm GKD; however, integration into clinical practice has been hampered by small studies, selective populations, and …

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Prevalence and characteristics of people with a high body mass index across the kidney disease spectrum: a population-based cohort study

Gurleen Sahi, Jennifer Reid, Michael Chiu, Louise Moist et autres

The prevalence of obesity is growing globally and has major health implications, particularly for those with chronic kidney disease (CKD). People with obesity have a higher risk of CKD progression and face barriers to transplantation. Studies on the epidemiology and outcomes of …

Prevalence, Characteristics, and Outcomes of People With A High Body Mass Index Across the Kidney Disease Spectrum: A Population-Based Cohort Study

Gurleen Sahi, Jennifer Reid, Louise Moist, Michael Chiu et autres

Background: Obesity has a major impact on health and health care, particularly in those with chronic kidney disease (CKD). Objective: The objective was to describe the prevalence, characteristics, and outcomes of people living with CKD and obesity (defined by a body mass …

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Glucagon-like peptide 1 receptor agonists in end-staged kidney disease and kidney transplantation: A narrative review

Kristin K. Clemens, Jaclyn Ernst, Tayyab Khan, Sonja M. Reichert et autres

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A New Perspective to Longstanding Challenges with Outpatient Hyperkalemia: A Narrative Review

Michael Chiu, Amit X. Garg, Louise Moist, Arsh K. Jain

Purpose of Review: Outpatient hyperkalemia is a common problem with potentially deadly consequences. Potassium level thresholds to treat outpatient hyperkalemia are unstandardized and variable, leaving health care providers to rely on their own clinical judgment. This narrative review highlights the challenges of …

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