Swetha Ramesh

A multimodal atlas of COVID-19 severity identifies hallmarks of dysregulated immunity 2258066

Kamil Slowikowski, Pritha Sen, Christopher V. Cosgriff, Jessica Tantivit et autres

Abstract Introduction The alpha-variant wave of the COVID-19 pandemic provided a unique opportunity to study, at single-cell resolution, how near-universal exposure to the same pathogen can lead to either effective or dysfunctional immune responses in humans. Methods We analyzed 2.5 million circulating …

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Pervasive cryptic selection in the human noncoding genome

Swetha Ramesh, Chenlu Di, Kirk E. Lohmueller

The prevailing dogma in evolutionary genetics holds that mutations within sequences that are conserved across a phylogeny are deleterious in those species, and mutations outside are neutrally evolving. Indeed, such comparative genomic approaches have estimated that mutations in approximately 5% of the …

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The landscape of fitness effects of putatively functional noncoding mutations in humans

Chenlu Di, Swetha Ramesh, Jason Ernst, Kirk E. Lohmueller

While annotations of noncoding regions in the human genome are increasing, the fitness effects of mutations in these regions remain unclear. Here, we leverage these functional genomic annotations and human polymorphism data to infer the distributions of fitness effects of new noncoding …

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Immune responses in checkpoint myocarditis across heart, blood and tumour

Steven M. Blum, Daniel A. Zlotoff, Neal P. Smith, Isabela Kernin et autres

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Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis

Molly Thomas, Kamil Slowikowski, Kasidet Manakongtreecheep, Pritha Sen et autres

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Engineering site-selective incorporation of fluorine into polyketides

Sasilada Sirirungruang, Omer Ad, Thomas M. Privalsky, Swetha Ramesh et autres

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Engineering site-selective incorporation of fluorine into natural product analogs

Sasilada Sirirungruang, Omer Ad, Thomas M. Privalsky, Swetha Ramesh et autres

Abstract While bioactive compounds are commonly derived both by human design as well as from living organisms, man-made and natural products typically display very different structural characteristics. As such, a longstanding goal in the discovery of new molecular function is to develop …

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