Cyriane Oeuvray

Functional changes in the gut microbiota are associated with the intestinal phenotype in A20 haploinsufficiency

Inès Elhani, Marius Bredon, Diana Enéa, Aurore Desmons et autres

BACKGROUND: A20 haploinsufficiency (HA20) is an autoinflammatory disease driven by pathogenic variants in TNFAIP3, which plays a crucial role in regulating immune responses. The clinical manifestations of HA20 resemble those of inflammatory bowel disease (IBD), with prominent gastrointestinal (GI) involvement. Given the …

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Author response for "Functional changes in the gut microbiota are associated with the intestinal phenotype in A20 haploinsufficiency"

Inès Elhani, Marius Bredon, Diana Enéa, Aurore Desmons et autres

Insulation of ribosomal promoter activity by Fis, H-NS or a divergent promoter within the packed E. coli genome.

Elisa Brambilla, Malikmohamed Yousuf, Qing Zhang, Gladys Mbemba et autres

Gene expression in bacterial cells is dependent on a gene&prime s position along the genome, mainly because of the effects of neighbouring genes&prime expression, but also because of the local activity of nucleoid proteins, differing levels of DNA supercoiling and changes in …

de, cn, fr, us, kz, it (code pays fourni par la source)

Gut microbiota alterations are associated with phenotype and genotype in familial Mediterranean fever

M. Delplanque, Nicolas Benech, Nathalie Rolhion, Cyriane Oeuvray et autres

OBJECTIVE: FMF is the most common monogenic autoinflammatory disease associated with MEFV mutations. Disease phenotype and response to treatment vary from one patient to another, despite similar genotype, suggesting the role of environmental factors. The objective of this study was to analyse …

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Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases

Chloé Michaudel, Camille Danne, Allison Agus, Aurélie Magniez et autres

OBJECTIVE: The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism end-products are essential to intestinal homeostasis. Here, we investigated the role of metabolites from the kynurenine …

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CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival

Camille Danne, Chloé Michaudel, Jūratė Skerniškytė, Julien Planchais et autres

Objectives Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflammation. Caspase recruitment domain 9 ( Card9 ), one of the IBD …

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Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

Morgane Modoux, Nathalie Rolhion, Jérémie H. Lefèvre, Cyriane Oeuvray et autres

Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between the gut microbiota and its host. However, factors regulating AhR within the gut, which is a complex metabolomic environment, are poorly understood. This study investigates the effect of a combination …

fr, cz, us (code pays fourni par la source)

Fecal microbiota and bile acids in IBD patients undergoing screening for colorectal cancer

Aonghus Lavelle, Stéphane Nancey, Jean‐Marie Reimund, David Laharie et autres

Due to the potential role of the gut microbiota and bile acids in the pathogenesis of both inflammatory bowel disease (IBD) and sporadic colorectal cancer, we aimed to determine whether these factors were associated with colorectal cancer in IBD patients. 215 IBD …

fr, ie, us, gb (code pays fourni par la source)

Human CD4+CD8α+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation

Sothea Touch, Emmanuelle Godefroy, Nathalie Rolhion, Camille Danne et autres

Abundance of Faecalibacterium prausnitzii, a dominant bacterium of the human microbiota that exhibits antiinflammatory effects, is decreased in patients with inflammatory bowel diseases (IBD). In humans, colonic lamina propria contains IL-10-secreting, Foxp3- Tregs characterized by a double expression of CD4 and CD8α …

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Human CD4 + /CD8α + regulatory T cells induced by Faecalibacterium prausnitzii protect against intestinal inflammation

Sothea Touch, Emmanuelle Godefroy, Nathalie Rolhion, Camille Danne et autres

ABSTRACT Faecalibacterium prausnitzii (F. prausnitzii) , a dominant bacterium of the human microbiota, is decreased in patients with inflammatory bowel diseases (IBD) and exhibits anti-inflammatory effects. In human, colonic lamina propria contains IL-10-positive, Foxp3-negative regulatory T cells (Treg) characterized by a double …

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CARD9 in Neutrophils Protects from Colitis and Controls Mitochondrial Metabolism and Cell Survival

Camille Danne, Chloé Michaudel, Jūratė Skerniškytė, Julien Planchais et autres

ABSTRACT Objectives Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflammation. Caspase recruitment domain 9 ( Card9 ), one of the …

fr (code pays fourni par la source)

SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota

Harry Sokol, Vanessa Contreras, Pauline Maisonnasse, Aurore Desmons et autres

The current pandemic of coronavirus disease (COVID) 2019 constitutes a global public health issue. Regarding the emerging importance of the gut-lung axis in viral respiratory infections, analysis of the gut microbiota’s composition and functional activity during a severe acute respiratory syndrome coronavirus …

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