Nívea Dias Amoêdo

Ex Vivo Assessment of Heat and Humidity Effects on Human Skin and Potential Protection by Kombucha Tea Extract

Julien Chlasta, Gaël Runel, Manon Boussard, T Pele-Joly et autres

Human skin homeostasis relies on the delicate equilibrium between epidermal stem cell renewal, dermoepidermal junction (DEJ) architecture, and environmental interactions. With aging and exposure to external stressors, this equilibrium becomes disrupted, leading to reduced regenerative capacity. In this study, we established an …

us, fr (code pays fourni par la source)

MELK controls tumor metabolism to promote resistance to melanoma therapy

Ana Carolina Bastos Sant'Anna Silva, Patricia Abbe, Sophie Pagnotta, Nívea Dias Amoêdo et autres

ABSTRACT Melanoma is the most aggressive form of skin cancer, and despite major advances in targeted and immune therapies, durable responses remain limited due to the emergence of resistance mechanisms. Metabolic reprogramming has emerged as a key driver of therapy resistance, allowing …

fr, us (code pays fourni par la source)

384 DHODH is a promising therapeutic target for cutaneous squamous cell carcinoma

Ferial Khalife, Elodie Muzotte, Walid Mahfouf, L. Dousset et autres

fr (code pays fourni par la source)

Diminution de l’état oxydatif et le maintien de l’état énergétique mitochondrial permettent la survie fonctionnelle des cellules après un stockage prolongé en hypothermie sévère sans congélation

Véronique Labat, Nívea Dias Amoêdo, Zoran Ivanović, Marija Vlaski‐Lafarge

fr (code pays fourni par la source)

P05-04 Protective effects of anethol trithione against cardiac toxicity induced by doxorubicin through a mitochondrial interaction

Richard Printemps, Stéphanie Guilbot, Lukas Roubenne, Francisco Marı́n et autres

fr, be (code pays fourni par la source)

Metabolism-based scoring of cutaneous squamous cell carcinoma to predict tumour features and responses to treatment with dihydroorotate dehydrogenase inhibitors

L. Dousset, Ferial Khalife, Domitille Chalopin-Fillot, Benjamin Dartigues et autres

BACKGROUND: Alteration in metabolic activities is a critical step in cancer progression. Myriad metabolic-based therapy options are increasingly being proposed for human tumours. However, emerging evidence highlights interpatient metabolic heterogeneity and underscores the importance of metabolic phenotyping in cancer treatment. OBJECTIVES: To …

fr, es (code pays fourni par la source)

Repression of oxidative phosphorylation by NR2F2, MTERF3 and GDF15 in human skin under high-glucose stress

Seyta Ley‐Ngardigal, Stéphane Claverol, Lauren Sobilo, M. Moreau et autres

Lifestyle factors such as a Western diet or metabolic diseases like diabetes disrupt glucose homeostasis and induce stress responses, yet their impact on skin metabolism and structural integrity remains poorly understood. Here, we performed multiomic and bioenergetic analyses of human dermal fibroblasts …

fr, nl (code pays fourni par la source)

Intégration des données histo-pathologiques, biochimiques et génomiques dans le diagnostic des mitochondrio-pathies

Aurélien Trimouille, Sarah Courtois, Chloé Angelini, Nívea Dias Amoêdo et autres

fr (code pays fourni par la source)

Mutation on MT-CO2 gene induces mitochondrial disease associated with neurodegeneration and intracerebral iron accumulation (NBIA)

Sarah Courtois, Chloé Angelini, Christelle M. Durand, Nívea Dias Amoêdo et autres

fr (code pays fourni par la source)

The deubiquitinase OTUB1 governs lung cancer cell fitness by modulating proteostasis of OXPHOS proteins

Aidana Sheryazdanova, Nívea Dias Amoêdo, Sara Dufour, Francis Impens et autres

be, fr (code pays fourni par la source)

Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer

Malak Alannan, Véronique Trézéguet, Nívea Dias Amoêdo, Rodrigue Rossignol et autres

Alterations in lipid handling are an important hallmark in cancer. Our aim here is to target key metabolic enzymes to reshape the oncogenic lipid metabolism triggering irreversible cell breakdown. We targeted the key metabolic player proprotein convertase subtilisin/kexin type 9 (PCSK9) using …

fr, lb (code pays fourni par la source)

HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models

Laetitia Dard, Christophe Hubert, Pauline Estèves, Wendy Blanchard et autres

Germline mutations that activate genes in the canonical RAS/MAPK signaling pathway are responsible for rare human developmental disorders known as RASopathies. Here, we analyzed the molecular determinants of Costello syndrome (CS) using a mouse model expressing HRAS p.G12S, patient skin fibroblasts, hiPSC-derived …

fr (code pays fourni par la source)