Nobuyoshi Azuma

Spatial Transcriptomics Reveals Region-Specific Remodeling in Vein Grafts After Peripheral Arterial Bypass

Keisuke Kamada, Hong Niu, Shinsuke Kikuchi, Nobuyoshi Azuma et autres

Abstract Background Vein graft failure due to intimal hyperplasia and maladaptive remodeling remains a major limitation of peripheral bypass surgery. Although vascular remodeling is recognized as a multilayered process, layer-specific molecular mechanisms that distinguish adaptive from negative remodeling remain incompletely understood. We …

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Clinical features and prognosis in patients with chronic limb-threatening ischemia receiving welfare in Japan

Yosuke Hata, Osamu Iida, Mitsuyoshi Takahara, Norihiko Ohura et autres

Background: In patients with chronic limb-threatening ischemia (CLTI), a subset of patients are beneficiaries of welfare assistance. We sought to investigate the clinical features and prognosis of patients with CLTI receiving welfare compared to those not receiving welfare in the Japanese population. …

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Open surgical conversion after endovascular aneurysm repair in Japan: Indications and outcomes from a multicenter study (JAST-CONVERT)

Koichi Morisaki, Masaki Sano, Keisuke Miyake, Shinsuke Kikuchi et autres

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Role of Extracellular Vesicles in Abdominal Aortic Aneurysm: Pathophysiology, Biomarkers, and Therapeutic Potentials

Kazuki Takahashi, Yusuke Yoshioka, Naoya Kuriyama, Shinsuke Kikuchi et autres

Abdominal aortic aneurysm (AAA) is a life-threatening disease. Although AAA is generally asymptomatic, the mortality rate remains very high once rupture occurs, even with successful treatment. The pathophysiology of AAA involves inflammatory cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. …

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Successful Surgical Treatment for Large Common Hepatic Arterial Aneurysm Incidentally Discovered during Evaluation for Mallory–Weiss Syndrome

Daichi Mizushima, Tsutomu Doita, Sayaka Yuzawa, Takayuki Uramoto et autres

Although both open and endovascular repair are available for hepatic artery aneurysms (HAAs), the optimal treatment strategy remains controversial, particularly in anatomically complex cases. In the present case, a large common HAA measuring 100 × 49 mm with a short proximal neck …

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Functional Limb Preservation after Surgical Distal Venous Arterialization with Free Flap in Chronic Limb-Threatening Ischemia with Severe Foot Arterial Disease

Chihiro Nakai, Shinsuke Kikuchi, Yuya Tamaru, Tsutomu Doita et autres

INTRODUCTION: In chronic limb-threatening ischemia (CLTI), especially with diabetes and dialysis dependence, below-the-ankle arterial lesions and severe calcification often limit distal bypass options. While surgical distal venous arterialization (sDVA) can restore perfusion, achieving wound healing requires additional surgical strategies such as free …

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Abstract 4368473: Comparative Outcomes of TEVAR and Non-TEVAR Management in Acute Uncomplicated Type B Aortic Dissection: Age-Stratified Analysis Using a Claims Database Including the Elderly in Japan

Yuki Kimura, Hiroshi Ohtsu, Naohiro Yonemoto, Nobuyoshi Azuma et autres

Background: Thoracic endovascular aortic repair (TEVAR) is the standard treatment for complicated type B aortic dissection, while randomized trials comparing TEVAR and optimal medical therapy for uncomplicated TBAD (uTBAD) are ongoing. Our previous study using a Japanese claims database reported long-term outcomes …

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Disaster-associated venous thromboembolism countermeasures in Japan: Insights from past major earthquakes

Keisuke Kamada, Eri Fukaya, Eriko Iwata, Daiki Uchida et autres

Japan experiences more than 1000 perceptible earthquakes annually, including major events such as the 2011 Great East Japan Earthquake and the 1995 Great Hanshin-Awaji Earthquake. These events lead to a documented increase in cardiovascular events, particularly venous thromboembolism (VTE), including pulmonary embolism …

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Deficiency of p27 kip1 , a Cyclin-Dependent Kinase Inhibitor, Accelerates Topical Elastase/3-Aminopropionitrile Fumarate Salt-Induced Abdominal Aortic Aneurysm Development in Mice

Keisuke Kamada, Hong Niu, Shinsuke Kikuchi, Nobuyoshi Azuma et autres

Introduction: Abdominal aortic aneurysm (AAA) is a multifactorial disease with limited identification of contributing genetic factors. p27kip, also known as CDKN1B, is a cell cycle inhibitor that regulates vascular smooth muscle cells (VSMCs) and macrophages (Mϕ). The role of p27 in AAA …

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Mid-Term Mortality Prediction Using Four Established Risk Scores in Patients with Chronic Limb-Threatening Ischemia Undergoing Cardiac Surgery

Yuki Setogawa, Shinsuke Kikuchi, Kyohei Oyama, Masahiro Tsutsui et autres

Objectives: Patients with chronic limb-threatening ischemia (CLTI) represent a high-risk cohort for cardiac surgery due to the systemic atherosclerotic burden and frailty. This study aimed to evaluate the short- and mid-term prognoses of CLTI patients undergoing open cardiac surgery and to assess …

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Chronic Contained Rupture of a Common Iliac Artery Aneurysm Presenting with Iliac Artery Occlusion: A Case Report

Hiroyuki Miyamoto, Shinsuke Kikuchi, Tomoki Nakatsu, Nobuyoshi Azuma

Iliac artery aneurysm rupture usually causes acute hemorrhagic shock requiring urgent intervention, whereas chronic contained rupture is rare and seldom reported. An 86-year-old male with hypertension presented with sudden lower back and left lower limb pain causing difficulty in walking. Four weeks …

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Long-term outcomes of initial thoracic endovascular repair versus medical therapy in acute uncomplicated type B aortic dissection: real-world evidence from a nationwide claims database in Japan – a retrospective cohort study

Yuki Kimura, Hiroshi Ohtsu, Naohiro Yonemoto, Nobuyoshi Azuma et autres

Objectives: To compare the long-term outcomes of initial thoracic endovascular aortic repair (TEVAR) versus initial medical therapy (iMT) in patients with acute uncomplicated type B aortic dissection (uTBAD), using real-world evidence from a nationwide claims database in Japan. This study aligns with …

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