Grace Baek

Nivolumab in combination with AVD as frontline treatment for patients with classic Hodgkin lymphoma: A real‐world analysis from 20 US centers

Allison M. Bock, Peirong Hao, Yizhe Xu, Efrat Luttwak et autres

Advanced-stage (AS) classic Hodgkin lymphoma (cHL) has been historically treated with combination chemotherapy regimens such as doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) or escalated doses of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (eBEACOPP).1, 2 While these approaches have achieved high …

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Real-world evidence for pembrolizumab gemcitabine vinorelbine and liposomal doxorubicin in classical Hodgkin lymphoma

Grace Baek, Gaurav Varma, Samuel Yamshon, Herman J van Besien et autres

Classical Hodgkin lymphoma (CHL) cure is achievable with first-line cytotoxic and novel agents and radiation.However, 10% relapse rates and 5% to 10% refractory rates necessitate salvage treatment, often followed by consolidative high-dose therapy and hematopoietic stem cell transplant (HCT).However, up to 80% …

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The Evolving Therapeutic Landscape of Richter Transformation

Henry H. Le, Grace Baek, Ivan Huang, Chloe Siu et autres

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A real-world analysis of safety and outcomes with first line nivolumab in combination with doxorubicin, vinblastine, and dacarbazine (NAVD) in patients with classic Hodgkin lymphoma (cHL) – a multicenter cohort study

Allison M. Bock, Efrat Luttwak, Elena Nazarenko, Yizhe Xu et autres

Abstract Introduction: NAVD has become a standard-of-care for frontline (1L) treatment (tx) of advanced stage cHL, based on the results of the S1826 study. S1826 demonstrated a 1-year progression free survival (PFS) of 94% for NAVD compared to 86% for brentuximab vedotin-AVD, …

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Nivolumab with doxorubicin, vinblastine, and dacarbazine (NAVD) in older adults with classic Hodgkin lymphoma: Do S1826 results hold up in the real world?

Pallawi Torka, Allison M. Bock, Elena Nazarenko, Yizhe Xu et autres

Abstract Introduction Older adults (OAs) with classic Hodgkin lymphoma (cHL) have inferior survival compared with younger patients (pts). NAVD has been widely adopted in clinical practice for frontline (1L) treatment of OAs with advanced stage cHL based on the subset analysis of …

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Abstract P1-06-06: Oral cyclophosphamide-induced hemorrhagic cystitis from metronomic Cyclophosphamide/Methotrexate/5-Fluorouracil for treatment of synchronous bilateral breast cancer – A case report

Jina Yun, Grace Baek, Arianne Duong, Dane Fritzsche et autres

Abstract Introduction: Cyclophosphamide/methotrexate/5-fluororuracil (CMF) has been used for the treatment of early-stage breast cancer since the 1970s. Cyclophosphamide, a main component of the CMF regimen, is an alkylating agent with potential to cause hemorrhagic cystitis. This side effect is thought to be …

High-Intensity Maintenance Post Autologous Stem Cell Transplant Is Independently Associated with Improved Event-Free Survival in Multiple Myeloma

Ivan Huang, Grace Baek, Gui Zhen Chen, Omar Marzouk et autres

Following induction therapy, consolidative autologous stem cell transplant (ASCT) and post-transplant maintenance remain a cornerstone for eligible patients with multiple myeloma (MM). Historically, lenalidomide or bortezomib-based monotherapy maintenance has been the standard of care. More aggressive maintenance regimens may be associated with …

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Enhancing Multiple Myeloma Care: Implementation of Pharmacist-Led Prescribing of Immunomodulatory Drugs in an Academic Medical Setting

Amy Indorf, Mary Kwok, Mark Jao, Ashley Chen et autres

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Evaluation of the Toxicity and Outcomes of the Combination of Midostaurin and CLAG-M in Patients With FLT3-Mutated Acute Myeloid Leukemia (AML): A Multicenter Retrospective Analysis

Ashley Chen, Grace Baek, Kathryn Russell, Carole Shaw et autres

Background: Addition of midostaurin to standard “7+3” (cytarabine and anthracycline) significantly prolongs overall and event-free survival. At University of Washington/Fred Hutchinson Cancer Center (UW/FHCC), the standard regimen for newly diagnosed (ND) and relapsed/refractory (R/R) AML is cladribine, high-dose cytarabine, GCSF, and mitoxantrone …

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Clinical Relevance of Intensive Laboratory Monitoring With Standard Venetoclax Ramp-Up for Chronic Lymphocytic Leukemia: A Real-World Experience

Ivan J. Huang, Grace Baek, Jonathan Cohen, Sirin Khajaviyan et autres

PURPOSE: Venetoclax is the standard of care for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) but requires intensive monitoring for optimal safety. Clinical relevance of intensive monitoring in practice is unknown, especially for patients with low or intermediate risk for tumor lysis …

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Pembrolizumab Gemcitabine Vinorelbine and Liposomal Doxorubicin (P-GVD) for Classical Hodgkin Lymphoma (CHL) in the Real-World Setting

Grace Baek, Gaurav Varma, Samuel Yamshon, Herman van Besien et autres

Introduction: Pembrolizumab Gemcitabine Vinorelbine and Liposomal Doxorubicin (P-GVD) has become a commonly employed regimen for the treatment of relapsed or refractory classical Hodgkin lymphoma (CHL), often preceding autologous stem cell transplant in patients with good response. The utilization of P-GVD is based …

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Concomitant Use of Antibiotics During Immune Checkpoint Inhibitor (CPI)-Based Salvage Therapy Does Not Impact Post-ASCT Outcomes in Patients with Relapsed/Refractory Hodgkin Lymphoma (RRHL)

Gaurav Varma, Maya Rosenberg, Erica C. Agbadiba, Ayo Falade et autres

Introduction Emerging evidence suggests that responses to CPI in Hodgkin lymphoma (HL) may be adversely affected by the reductions in microbiome diversity associated with concomitant antibiotic (abx) exposure. Given the increasingly key role that CPI-based regimens (CPI+) appear to have on improving …

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