William Wroe

Microthrombi and hypercoagulability’s contribution to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

William Wroe, Hussein A. Zeineddine, Spiros Blackburn, Jaroslaw Aronowski et autres

Despite increasing knowledge over the last several decades of the factors contributing to delayed cerebral ischemia (DCI), it remains a significant cause of morbidity after aneurysmal subarachnoid hemorrhage (aSAH). The hypercoagulable state induced by aneurysm rupture is critical to most proposed mechanisms …

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Outcomes after flow diversion for ruptured blood blister-like and dissecting aneurysms: A single-center series

William Wroe, Hussein A. Zeineddine, Si Yu, B. Freeman et autres

BackgroundFlow diverter (FD) use has become a popular method for treating intracranial aneurysms, but evidence in acutely ruptured blood blister-like and dissecting morphologies is limited. Furthermore, there is little evidence regarding the role of short-term follow-up imaging to assess aneurysm stability. This …

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Delayed, catastrophic expansion of acute traumatic subdural hematomas: a case series

Shivani Bindal, William Wroe, W. Allister Dow, Ryan S. Kitagawa

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The role of neutrophils in vasospasm and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: Is it time for a SAH clinical trial targeting neutrophils?

William Wroe, Hussein A. Zeineddine, Spiros Blackburn, Jaroslaw Aronowski et autres

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurological disease, and one of the primary drivers of morbidity after aneurysm rupture is the phenomenon of delayed cerebral ischemia (DCI). Significant knowledge has been gained over the past two decades of the impact of …

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Dynamic vertebral artery recanalization as a cause for recurrent posterior circulation thromboembolic stroke: illustrative case

Hussein A. Zeineddine, G. A. Castro, Antonio Dono, William Wroe et autres

BACKGROUND: Posterior circulation strokes comprise one-fourth of ischemic strokes and can arise from many causes. One rare etiology is transient occlusion of the vertebral artery (VA) with head rotation due to an osteophyte, termed bow hunter's syndrome. The authors present the case …

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Abstract WP35: Neutrophil Extracellular Traps As a Biomarker for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage

Hussein A. Zeineddine, Ari Dienel, Sithara Thomas, William Wroe et autres

Neutrophils are reported to be critical mediators of to poor outcome after subarachnoid hemorrhage (SAH). Following SAH, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs) and NETs have been identified as a therapeutic target to prevent delayed cerebral ischemia in mice …

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432 Middle Meningeal Artery Embolization Reduces Recurrence Following Surgery for Septated Chronic Subdural Hematomas

Hussein A. Zeineddine, Juan Carlos Martínez-Gutiérrez, Bryden H. Dawes, William Wroe et autres

INTRODUCTION: Chronic subdural hematoma (cSDH) causes a significant burden of disease and plagued by hematoma recurrence after surgical evacuation, particularly in septated cSDH. Middle meningeal artery embolization (MMAE) has emerged as a promising treatment both as an adjunct to surgery and as …

870 Middle Meningeal Artery Embolization Does Not Confer Protection Against Symptomatic Recurrence in Patients With Early Anticoagulation Following Surgery for Chronic Subdural Hematomas

Hussein A. Zeineddine, Bryden H. Dawes, Juan Carlos Martínez-Gutiérrez, William Wroe et autres

INTRODUCTION: Chronic subdural hematoma (cSDH) is a prevalent condition that carries a significant burden. Middle meningeal artery embolization (MMAE) has emerged as a promising treatment both as an adjunct to surgery and as a primary treatment. A number of patients suffering from …

Incidence and factors in delayed neurological deficits after subarachnoid hemorrhage in mice

William Wroe, Ari Dienel, Sung‐Ha Hong, Kanako Matsumura et autres

Background: Delayed cerebral ischemia (DCI) is one of the most feared complications in aneurysmal subarachnoid hemorrhage (SAH). Animal models are crucial to studying the disease mechanisms and potential treatments. DCI in rodents was thought to not exist; herein we examine literature and …

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Treatment of Traumatic Direct Carotid Cavernous Fistula With a PK Papyrus Covered Stent: A Report of 2 Cases

William Wroe, Hussein A. Zeineddine, Bryden H. Dawes, Juan Carlos Martínez-Gutiérrez et autres

Background: Traumatic direct carotid cavernous fistulas results in a direct communication between the internal carotid artery and the cavernous sinus. Covered stents are not frequently used in neuro-endovascular procedures due to concerns primarily about occlusion of perforating vessels. There are however several …

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