Goro Uehara

Efficacy and Safety of Adding Sitagliptin in Type 2 Diabetes Patients on Insulin: Age-Stratified Comparison at One Year in the ASSIST-K Study

Masahiko Takai, Masashi Ishikawa, Hajime Maeda, Akira Kanamori et autres

BACKGROUND: Sitagliptin, the first dipeptidyl peptidase-4 inhibitor, has demonstrated efficacy and safety as monotherapy and as add-on therapy to oral antidiabetic agents or insulin. However, there have been few reports about sitagliptin in elderly patients. The ASSIST-K observational study was performed in …

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Add-On Sitagliptin Therapy for Insulin-Treated Type 2 Diabetes: An Analysis of Hemoglobin A1c and Other Variables Using ASSIST-K Follow-Up Data

Masashi Ishikawa, Masahiko Takai, Hajime Maeda, Akira Kanamori et autres

Background: Sitagliptin was the first dipeptidyl peptidase-4 (DPP-4) inhibitor approved in Japan. Its efficacy and safety have been demonstrated, both as monotherapy and in combination with oral antidiabetic agents or insulin. However, reduction of hemoglobin A1c (HbA1c) by sitagliptin is insufficient in …

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Factors Predicting Therapeutic Efficacy of Combination Treatment With Sitagliptin and Insulin in Type 2 Diabetic Patients: The ASSIST-K Study

Masashi Ishikawa, Masahiko Takai, Hajime Maeda, Akira Kanamori et autres

BACKGROUND: It is unclear whether dipeptidyl peptidase-4 inhibitors decrease hemoglobin A1c (HbA1c) in a glucose-dependent manner in patients on insulin therapy who have impaired insulin secretion. This study investigated factors influencing the efficacy of sitagliptin when used concomitantly with insulin to treat …

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Safety and efficacy of adding sitagliptin to insulin in patients with type 2 diabetes: The ASSIST-K study

Masahiko Takai, Masashi Ishikawa, Hajime Maeda, Akira Kanamori et autres

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Relative Effects of Telmisartan, Candesartan and Losartan on Alleviating Arterial Stiffness in Patients with Hypertension Complicated by Diabetes Mellitus: An Evaluation Using the Cardio-Ankle Vascular Index (CAVI)

Goro Uehara, Hiroshi Takeda

Using the cardio-ankle vascular index (CAVI) as an indicator, we assessed improvement of arterial stiffness in 95 outpatients with hypertension complicated by type 2 diabetes mellitus who were treated orally for >or= 12 months with telmisartan 40 mg/day, losartan 50 mg/day or …

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Vascular endothelial growth factor gene expression is correlated with glomerular neovascularization in human diabetic nephropathy

Yoshinobu Kanesaki, Daisuke Suzuki, Goro Uehara, Masao Toyoda et autres

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High expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy

Masao Toyoda, Daisuke Suzuki, Masashi Honma, Goro Uehara et autres

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Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-?, -? in human diabetic nephropathy

Goro Uehara, Daisuke Suzuki, Masao Toyoda, Tomoya Umezono et autres

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Glomerular expression of connective tissue growth factor mRNA in various renal diseases

Daisuke Suzuki, Masao Toyoda, Tomoya Umezono, Goro Uehara et autres

Connective tissue growth factor (CTGF) is a cysteine-rich member of a new family of growth regulators. It is an important factor in the pathogenesis of mesangial matrix accumulation and progressive glomerulosclerosis. The present study was designed to elucidate the role of CTGF …

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Variant expressions of connective tissue growth factor and transforming growth factor‐β in human IgA nephropathy by in situ hybridization

Tomoya Umezono, Daisuke Suzuki, Masao Toyoda, S. Zhang et autres

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High expression of connective tissue growth factor mRNA is an important factor in the pathogenesis of human IgA nephropathy

Masao Toyoda, Daisuke Suzuki, Tomoya Umezono, Goro Uehara et autres

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[A case of antiphospholipid antibody syndrome with variable renal histological change despite of poor changes in urinalysis].

Masao Toyoda, Daisuke Suzuki, T. Sakai, Goro Uehara et autres

We experienced a case of lupus nephritis with antiphospholipid antibody syndrome. A renal biopsy specimen from this patient showed various renal histological changes, but the results of urinalysis were almost normal. The patient was a 56-year-old woman diagnosed as having systemic lupus …

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