Mathias Orban

Guided de-escalation of antiplatelet treatment in patients at high atherothrombotic risk presenting with acute coronary syndrome: a post hoc analysis of the TROPICAL-ACS trial

Serdar Farhan, Ralph Hein, Dietmar Trenk, Lisa Groß et autres

AIMS: Platelet function testing (PFT)-guided de-escalation of dual antiplatelet therapy (DAPT) after acute coronary syndrome (ACS) has been shown to reduce bleeding risk without increasing ischaemic events. Patients with high atherothrombotic risk (ATR) remain a challenging subgroup for such strategies. This study …

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Predictors of depression and anxiety disorders in a large cohort of employed German statutory health insurance patients

Anne Zutavern, Christiane Suchy, Mathias Orban, Alban Senn

Introduction. Mental illness is very common and is one of the most frequent causes of occupational disability, resulting in a high economic burden. A large proportion of mental illnesses remain undetected for a long time because patients present to clinicians with physical …

Getting Imaging Right

Mathias Orban, Nicole Karam, Lukas Stolz, Philipp C. Lurz et autres

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Ten Future Challenges in the Field of Transcatheter Mitral Valve Edge-to-Edge Repair

Mathias Orban, Ludwig T. Weckbach, Thomas J. Stocker, Philipp M. Doldi et autres

Mitral valve transcatheter edge-to-edge repair (M-TEER) and replacement (TMVR) have evolved as guideline-recommended treatment approaches for mitral regurgitation (MR). Even though they are supported by a growing body of evidence from either randomized trials or large registries, there are still several unsolved …

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Artificial intelligence-derived risk score for mortality in secondary mitral regurgitation treated by transcatheter edge-to-edge repair: the EuroSMR risk score

Jörg Hausleiter, Mark Lachmann, Lukas Stolz, Francesco Bedogni et autres

BACKGROUND AND AIMS: Risk stratification for mitral valve transcatheter edge-to-edge repair (M-TEER) is paramount in the decision-making process to appropriately select patients with severe secondary mitral regurgitation (SMR). This study sought to develop and validate an artificial intelligence-derived risk score (EuroSMR score) …

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Troponin in cardiogenic shock not caused by acute myocardial infarction, a predictor of mortality

B N Beer, J Sundermeyer, Andrea C. Dettling, Lisa Besch et autres

Abstract Background Cardiogenic shock is associated with a high mortality and morbidity due to organ damage and multi-organ failure including direct damage to the myocardium. Purpose This study aimed to assess troponin as a marker of myocardial damage in patients with cardiogenic …

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Multiphoton In Vivo Microscopy of Embryonic Thrombopoiesis Reveals the Generation of Platelets through Budding

Huan Liu, Hellen Cristina Ishikawa-Ankerhold, Julia Winterhalter, Michael C. Lorenz et autres

Platelets are generated by specialized cells called megakaryocytes (MKs). However, MK’s origin and platelet release mode have remained incompletely understood. Here, we established direct visualization of embryonic thrombopoiesis in vivo by combining multiphoton intravital microscopy (MP-IVM) with a fluorescence switch reporter mouse …

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Expanding Success of Mitral Transcatheter Edge-to-Edge Repair in Real-World Patients

Mathias Orban, Jörg Hausleiter

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Two-Year Outcomes for Tricuspid Repair With a Transcatheter Edge-to-Edge Valve Repair From the Transatlantic TRILUMINATE Trial

Philipp C. Lurz, Paul Sorajja, Tobias Friedrich Ruf, Jörg Hausleiter et autres

BACKGROUND: Tricuspid regurgitation (TR) is a common and progressive valve disease with significant mortality and hospitalization burden. Tricuspid transcatheter edge-to-edge repair provides a treatment option for high-risk patients with primary and secondary TR. METHODS: The TRILUMINATE trial ([Trial to Evaluate Treatment With …

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Transcatheter Therapy for Tricuspid Regurgitation — First Act

Mathias Orban, Steffen Maßberg

Severe tricuspid regurgitation is associated with impaired quality of life and poor survival.1 The condition is managed medically with diuretic agents; surgery is of limited use, since many patients have a variety of coexisting conditions that increase surgical risk. Current U.S. and …

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Right Ventricular Reverse Remodeling Following Mitral Valve Transcatheter Edge-to-Edge Repair

Lukas Stolz, Ludwig T. Weckbach, Philipp M. Doldi, Thomas J. Stocker et autres

Transcatheter Mitral Valve Replacement or Repair for Secondary Mitral Regurgitation: A Propensity Score-Matched Analysis

Sebastian Ludwig, Daniel Kalbacher, Walid Ben Ali, Jessica Weimann et autres

AIMS: This study aimed to compare outcomes after transcatheter mitral valve replacement (TMVR) and mitral valve transcatheter edge-to-edge repair (M-TEER) for the treatment of secondary mitral regurgitation (SMR). METHODS AND RESULTS: The CHOICE-MI registry included 262 patients with SMR treated with TMVR …

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