N.V. Litvyakov

STADIES OF LYSOSOMAL ENTOSIS IN LUNG AND COLORECTAL CANCER

K.A. Gaptulbarova, E. A. Kravtsova, С. В. Вторушин, N.V. Litvyakov

MECHANISMS OF DEDIFFERENTIATION OF NON-LIGHT BREAST CANCER CELLS TO STEM CELLS

Daria S. Dolgasheva, E.A. Zdereva, I.A. Cydenova, K.A. Gaptulbarova et autres

It is known that the ability to dedifferentiate in non-stem cells causes its malignancy and its ability to metastasize [1]. The lack of a tendency to dedifferentiate and detect the affected stem phenotype explains the inability to metastasize within one localization. Previously, …

PREDICTIVE AND PROGNOSTIC SIGNIFICANCE OF EXPRESSION AND ABERRATIONS OF THE DNA COPY NUMBER OF CHEMOSENSITIVITY GENES IN PATIENTS WITH BREAST CANCER

Ekaterina A. Zdereva, М. М. Цыганов, N.V. Litvyakov, М. К. Ибрагимова

Increasingly, researchers are focusing on the susceptibility of breast tumors (BC) to certain chemotherapy drugs and personalizing studies based on an assessment of this susceptibility. One such personalized approach is the assessment of chemotherapy gene expression and aberrations in the number of …

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EFFECT OF THE NUMBER OF STEMNESS GENE AMPLIFICATIONS ON THEIR EXPRESSION LEVEL AND SUBPOPULATION COMPOSITION OF CELL LINES AND TUMORS OF BREAST CANCER PATIENTS

Daria S. Dolgasheva, E. A. Kravtsova, Irina A. Tsydenova, K.A. Gaptulbarova et autres

Metastatic disease is the main cause of death in cancer patients; therefore, it is relevant to study various mechanisms of metastasis. The aim of this work is to study the influence of the number of stemness gene amplifications on the subpopulation composition …

EFFECT OF ACTIVATION OF MYC GENE EXPRESSION ON A METASTASIS POTENTIAL OF A BREAST CANCER CELL LINE

Ekaterina V. Sukhinina, Polina K. Kozlova, K. V. Nevskaya, N.V. Litvyakov et autres

The overexpression of the MYC gene plays a crucial role in the advancement of tumors and the plasticity of malignant cells. This study aimed to create breast cancer cell line BT-549 with activated MYC gene, using the CRISPR/Cas9-based SAM activation technique. The …