Kamran Alimoghaddam

The Impact of CYP3A4, CYP3A5, and ABCB1 Polymorphisms on Cyclosporine Concentration in Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation

Zahra Salehi, Amirhossein Shahsavand, Mohammad Naghizadeh, Molouk Hadjibabaie et autres

Cyclosporine A (CsA) is used as graft-versus-host disease (GVHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (HSCT). While polymorphisms in CYP3A4, CYP3A5, and ABCB1 genes influence CsA metabolism, their role in HSCT remains underexplored. We investigated the impact of these polymorphisms on …

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Comprehensive insights into tuberculosis-associated hemophagocytic lymphohistiocytosis: a systematic review

Arvin Eslami, Shaya Alimoghadam, Sanaz Khodadadi, H seyin Allahverdi et autres

BACKGROUND: Tuberculosis-associated hemophagocytic lymphohistiocytosis (TB-HLH) presents significant challenges in diagnosis and treatment due to its complex interplay between TB and HLH. This systematic review aims to provide comprehensive insights into the epidemiology, clinical characteristics, and treatment outcomes of TB-HLH patients. METHODS: We …

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PB2178: EVALUATION OF JAK2 EXON 12 MUTATIONS IN PATIENTS WITH JAK2 (V617F)-NEGATIVE POLYCYTHEMIA VERA

Sahar Khosravi, Bahram Chahardouli, Pouyan Ebrahimi, Fatemeh Naghdi Babaei et autres

Topic: 15. Myeloproliferative neoplasms - Biology & Translational Research Background: Polycythemia vera (PV) disease is an acquired and clonal stem cell disorder characterized by abnormal erythropoiesis. Identifying a unique mutation of increased activity in the Janus kinase 2 (JAK2) gene in patients …

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Fanconi anemia phenotypic and transplant outcomes' associations in Iranian patients

Faezeh Ansari, Maryam Behfar, Parisa Naji, Zahra Darvish et autres

Abstract Objectives Fanconi anemia (FA) is a rare, heterogeneous, inherited disorder. Allogeneic hematopoietic stem cell transplantation (HSCT) represents the only therapeutic option to restore normal hematopoiesis. This study reports the outcomes of FA‐HSCT patients and identifies factors, including clinical phenotype. Our team …

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The long-term outcome and efficacy of PR1/BCR-ABL multipeptides vaccination in chronic myeloid leukemia: results of a 7-year longitudinal investigation

Seyed H. Ghaffari, Ebrahim Osfouri, Mohammad Ahmadvand, Davood Bashash et autres

Background:Although Imatinib has revolutionized the treatment of chronic myeloid leukemia (CML), not all patients reach complete remission and a considerable proportion of the patients develop resistance to Imatinib. Material and Methods:In an attempt to increase the tail on the survival curve, we …

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Overexpression of Bromodomain and Extraterminal Domain is Associated with Progression, Metastasis and Unfavorable Outcomes: Highlighting Prognostic and Therapeutic Value of the BET Protein Family in Gastric Cancer

Seyed H. Ghaffari, Shahrzad Soleymani Fard, Shaghayegh Kouchaki, Zahra Salimian et autres

BACKGROUND: As epigenetic readers, Bromodomain and extraterminal domain (BET) proteins have attracted immense interest in developing novel therapies targeting this family to inhibit cancer progression. Although the impact of BRD4 in the carcinogenesis of various tumors has been widely investigated, little is …

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Incidence and Prognostic Impact of WT-1 Gene Exon7 and 9 Mutations in Acute Promyelocytic Leukemia

Fatemeh Nejatifar, Shahrbano Rostami, Barham Chahardouli, Amir Kasaeian et autres

Background: Wilms’ tumor gene 1 (WT1) gene mutation has been reported to be a prognostic factor in normal-cytogenetic acute myeloid leukemia (AML) patients. Higher rates of mutation in the WT1 gene have been reported in several tumors including normal-cytogenetic AML patients. Data …

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A Comparison of Dexamethasone plus Vincristine versus Standard Regimen in Induction Therapy of Adult Acute Lymphoblastic Leukemia Patients Undergoing Hematopoietic Stem Cell Transplantation

Mohammad Vaezi, Amirhoushang Pourkhani, Amir Kasaeian, Maryam Souri et autres

Background: Current treatment options of acute lymphoblastic leukemia(ALL) include chemotherapy alone or hematopoietic stem cell transplantation (HSCT) following induction chemotherapy both along with CNS prophylaxis. The usual and standard induction regimens currently administered could have severe complications and mortality. Materials and Methods: …

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A fludarabine and melphalan reduced-intensity conditioning regimen for HSCT in fifteen chronic granulomatous disease patients and a literature review

Mohammad Vaezi, Maryam Souri, Seyed Amin Setarehdan, Amir Ali Hamidieh et autres

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Relationship between endocrine changes and bone markers in pediatric thalassemic patients after hematopoietic stem cell transplantation

Amir Ali Hamidieh, Zohreh Hamidi, Maryam Behfar, Zeinab Pajouhi et autres

BACKGROUND: Beta thalassemia major and its treatment by hematopoietic stem cell transplantation can have deleterious effects on bone integrity and a main part of such effects is due to their deleterious effects on endocrine systems. So, we assessed the effects of endocrine …

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Relationship between endocrine changes and bone markers in pediatric thalassemic patients after hematopoietic stem cell transplantation.

Hamidieh Aa, Zohreh Hamidi, Maryam Behfar, Zeinab Pajouhi et autres

BACKGROUND: Beta thalassemia major and its treatment by hematopoietic stem cell transplantation can have deleterious effects on bone integrity and a main part of such effects is due to their deleterious effects on endocrine systems. So, we assessed the effects of endocrine …

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Concurrent Evaluation of the Expression and Methylation of secreted frizzled-related protein 2 along with beta-catenin Expression in Patients with non-M3 Acute Myeloid Leukemia.

Fatemeh Mirzaeyan, Bahram Chahardouli, Amin Mirzaeian, Nasrin Alizad Ghandforoush et autres

Background: non-M3 AML. Methods: test (SPSS software, version 23). A P value of less than 0.05 (2-tailed) was considered significant. Results: increased significantly in the patients in comparison with the controls (P<0001), and a significant difference was observed between the patients, who …

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