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Jinxiu Rui, Songyan Deng, Ana Luisa Perdigoto, Gerald Ponath et autres
β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). Here we report a role of their expression of Tet2 in regulating immune killing. Tet2 is induced in murine and human β cells with inflammation but its …
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Kelly M. Gillen, Mayyan Mubarak, Calvin Park, Gerald Ponath et autres
Abstract Background Inflammation in chronic active lesions occurs behind a closed blood–brain barrier and cannot be detected with MRI. Activated microglia are highly enriched for iron and can be visualized with quantitative susceptibility mapping (QSM), an MRI technique used to delineate iron. …
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Jinxiu Rui, Songyan Deng, Gerald Ponath, Romy Kursawe et autres
Abstract β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). We identified a novel role of Tet2 in regulating immune killing of β cells. Tet2 is induced in murine and human β cells with inflammation but …
us (code pays fourni par la source)
Calvin Park, Gerald Ponath, Maya Levine-Ritterman, Edward Bull et autres
Activated myeloid cells and astrocytes are the predominant cell types in active multiple sclerosis (MS) lesions. Both cell types can adopt diverse functional states that play critical roles in lesion formation and resolution. In order to identify phenotypic subsets of myeloid cells …
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Calvin Park, Gerald Ponath, Maya Levine-Ritterman, Edward Bull et autres
Abstract Activated myeloid cells and astrocytes are the predominant cell types in active multiple sclerosis (MS) lesions. Both cell types can adopt diverse functional states that play critical roles in lesion formation and resolution. In order to identify phenotypic subsets of myeloid …
us, ca (code pays fourni par la source)
Gerald Ponath, Matthew R. Lincoln, Maya Levine-Ritterman, Calvin Park et autres
Abstract Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090 G , located near …
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