Accès ouvert
2026
article
OpenAlex
Prioty F. Sarwar, Trevor J. Barker, Ken C. Q. Nguyen, Fung‐Yi Chan et autres
The apical extracellular matrix can form elaborate three-dimensional structures on animal surfaces. To better understand the mechanisms that pattern and shape these structures, we focus on development of collagen-rich cuticle ridges (alae) in adult C. elegans. Previous studies suggested that longitudinal actin …
us, pt
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Vanessa Teixeira, Kashish Singh, José B. Gama, M. V. B. Moreira et autres
The ER relies on the microtubule cytoskeleton for the organization of its extended membrane network, but how microtubule-based motors contribute remains unclear. Using biochemical and cell-based assays, we identify cerebellar degeneration-related protein 2 (CDR2) and its paralog CDR2-like (CDR2L), onconeural antigens with …
pt, ar, es, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mikhail O. Lebedev, Fung‐Yi Chan, Elisabeth Rackles, Jennifer Bellessem et autres
During unilateral furrow ingression, one side of the cytokinetic ring (leading edge) ingresses before the opposite side (lagging edge). Anillin mediates unilateral furrowing during cytokinesis in the one-cell C. elegans zygote by limiting myosin II accumulation in the ring. Here, we address …
de, pt
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Cátia Carvalho, Daniel José Barbosa, Fung‐Yi Chan, Carlota Boal Koehnen et autres
The microtubule motor cytoplasmic dynein-1 transports and positions various organelles, but the molecular basis of this functional diversity is not fully understood. Cargo adaptors of the Hook protein family recruit dynein to early endosomes (EE) in fungi and human cells by forming …
pt, gb
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Vanessa Teixeira, Kashish Singh, José B. Gama, Ricardo Celestino et autres
The endoplasmic reticulum (ER) relies on the microtubule cytoskeleton for distribution and remodelling of its extended membrane network, but how microtubule-based motors contribute to ER organization remains unclear. Using biochemical and cell-based assays, we identify cerebellar degeneration-related protein 2 (CDR2) and its …
pt, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
M.I.A. Barbosa, Jorge Belinha, Renato Natal Jorge, Ana Xavier Carvalho
Cancer is widely regarded as a critical health issue in modern society. Tumour cells are usually associated with abnormal proliferation that disrupts the normal behaviour of the body. All cells depend on the availability of oxygen and nutrients present in the extracellular …
pt
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Cátia Carvalho, Daniel José Barbosa, Ricardo Celestino, Esther Zanin et autres
The microtubule motor dynein is critical for the assembly and positioning of mitotic spindles. In Caenorhabditis elegans, these dynein functions have been extensively studied in the early embryo but remain poorly explored in other developmental contexts. Here, we use a hypomorphic dynein …
pt, de
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Cátia Carvalho, Daniel José Barbosa, Ricardo Celestino, Esther Zanin et autres
ABSTRACT The microtubule motor dynein is critical for the assembly and positioning of mitotic spindles. In C. elegans , these dynein functions have been extensively studied in the early embryo but remain poorly explored in other developmental contexts. Here we use a …
pt, de
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Mikhail O. Lebedev, Fung‐Yi Chan, Anna Lochner, Jennifer Bellessem et autres
During cytokinesis, a contractile ring consisting of unbranched filamentous actin (F-actin) and myosin II constricts at the cell equator. Unbranched F-actin is generated by formin, and without formin no cleavage furrow forms. In Caenorhabditis elegans, depletion of septin restores furrow ingression in …
de, pt
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Inês C. Santos, Ana Marta Silva, Reto Gassmann, Ana Xavier Carvalho
Cytokinesis is the last step of cell division, when one cell physically divides into two cells. Cytokinesis is driven by an equatorial contractile ring and signals from antiparallel microtubule bundles (the central spindle) that form between the two masses of segregating chromosomes. …
pt
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Trevor J. Barker, Fung‐Yi Chan, Ana Xavier Carvalho, Meera V. Sundaram
vulva is a polarized epithelial tube that has been studied extensively as a model for cell-cell signaling, cell fate specification, and tubulogenesis. Here we used endogenous fusions to show that the spectrin cytoskeleton is polarized in this organ, with conventional beta-spectrin ( …
us, pt
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
M.I.A. Barbosa, Jorge Belinha, Renato Natal Jorge, Ana Xavier Carvalho
Cell proliferation is vital for the development and homeostasis of the human body. For such to occur, cells go through the cell cycle during which they replicate their genetic material and ultimately complete cellular division, when one cell divides into two new …
pt
(code pays fourni par la source)