Rakel Brendsdal Forthun

Relapse of Acute Myeloid Leukemia With Concomitant Systemic Mastocytosis Five Years Post Allogenic Hematopoietic Stem Cell Transplantation

Sona Vardanyan, Hilde Kollsete Gjelberg, Lars Helgeland, Galina Tsykunova et autres

Systemic mastocytosis (SM) with associated hematological neoplasia (SM-AHN) is a rare and aggressive condition characterized by abnormal clonal proliferation of mast cells and the concurrent occurrence of hematologic malignancies, such as acute myeloid leukemia (AML). We present a 41-year-old female diagnosed with …

no (code pays fourni par la source)

Non- MPL -W515K/L mutations in myeloproliferative neoplasms: Insights from two case reports and a review of the literature

A. Nesse, Hilde Kollsete Gjelberg, Miriam Sandnes, Rakel Brendsdal Forthun et autres

Background Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) result from clonal proliferation of hematopoietic stem cells, and include polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Key driver mutations in the JAK2, CALR, and MPL genes are important for diagnosis and differentiation …

no (code pays fourni par la source)

RUNX1::MECOM rearrangement in myeloid neoplasm post cytotoxic therapy following sarcoma treatment: a case presentation and review of the literature

Miriam Sandnes, Øystein Sefland, Irini Ktoridou-Valen, Rakel Brendsdal Forthun et autres

Objectives Myeloid neoplasms occurring after cytotoxic therapy (MN-pCT), previously termed therapy-related myelodysplastic neoplasia (MDS) or therapy-related acute myelogenous leukemia (AML), pose significant treatment challenges due to high resistance, poor chemotherapy tolerance, and relapse.Methods We present a 73-year-old woman with therapy-related AML following …

no (code pays fourni par la source)

Assessment of postoperative circulating tumour DNA to predict early recurrence in patients with stage I–III right-sided colon cancer: prospective observational study

Kristin B Lygre, Rakel Brendsdal Forthun, Trude Høysæter, Sigrun M. Hjelle et autres

BACKGROUND: Right-sided colon cancer (RCC) differs in mutation profile and risk of recurrence compared to distal colon cancer. Circulating tumour DNA (ctDNA) present after surgery can identify patients with residual disease after curative surgery and predict risk of early recurrence. METHODS: This …

no (code pays fourni par la source)

213P Unlocking cancer treatment opportunities by population-based advanced diagnostics in Norway

H.E.G. Russnes, H.L. Nilsen, Mari Jebens, Emiel A. M. Janssen et autres

no (code pays fourni par la source)

Treatment and Response Evaluation Challenges in a Pregnant Woman With B-Cell Lymphoblastic Leukemia and Li-Fraumeni Syndrome

Bjarte Skoe Erikstein, Aymen Bushra Ahmed, Rakel Brendsdal Forthun, Friedemann Leh et autres

gene mutations with important therapeutic and prognostic implications for many types of cancer. A small proportion of LFS patients develop B-cell lymphoblastic leukemia (B-ALL) in adult years. Standard treatment often proves inadequate, but immunotherapy has provided new treatment options. The current case …

no (code pays fourni par la source)

A national precision cancer medicine implementation initiative for Norway

Kjetil Taskén, Hege Elisabeth Giercksky Russnes, Eline Aas, Line Bjørge et autres

no, jp, nl (code pays fourni par la source)

Novel hybridization- and tag-based error-corrected method for sensitive ctDNA mutation detection using ion semiconductor sequencing

Kjersti Tjensvoll, Morten Lapin, Bjørnar Gilje, Herish Garresori et autres

Circulating tumor DNA (ctDNA) analysis has emerged as a clinically useful tool for cancer diagnostics and treatment monitoring. However, ctDNA detection is complicated by low DNA concentrations and technical challenges. Here we describe our newly developed sensitive method for ctDNA detection on …

no, fr (code pays fourni par la source)

KRAS mutation analysis by droplet digital PCR of duodenal juice from patients with MODY8 and other pancreatic diseases

Man Hung Choi, Erling Tjora, Rakel Brendsdal Forthun, Trond Engjom et autres

BACKGROUND: Maturity-onset diabetes of the young type 8 (MODY8 or CEL-MODY) is an inherited pancreatic disease characterized by chronic inflammation of the pancreas and diabetes. It is not known whether MODY8 patients have increased risk for developing pancreatic cancer. We investigated KRAS …

no (code pays fourni par la source)

Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System

Oddmund Nordgård, Rakel Brendsdal Forthun, Morten Lapin, Bjørn Henning Grønberg et autres

Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the clinical relevance of liquid biopsy assessments. We also discuss the implementation …

no (code pays fourni par la source)

Preclinical characterisation and development of a novel myelodysplastic syndrome‐derived cell line

Sahba Shafiee, Pascal Gélébart, Mihaela Lucia Popa, Monica Hellesøy et autres

The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.

no, us, jp (code pays fourni par la source)

Partial Response to Sorafenib in a Child With a Myeloid/Lymphoid Neoplasm, Eosinophilia, and a ZMYM2-FLT3 Fusion

Monica Cheng Munthe‐Kaas, Rakel Brendsdal Forthun, Atle Brendehaug, Anette Kildal Eek et autres

Dysregulated tyrosine kinases in myeloid/lymphoid neoplasms with eosinophilia are rare, but do occur in children. To increase awareness of this diagnosis, we present a child who was diagnosed after a 3-year disease history. The patient was initially treated according to a T-cell …

de, no (code pays fourni par la source)