Wino J. Wijnen

IL-23 promotes T cell trafficking in experimental autoimmune myocarditis

Daria Vdovenko, Monika Stefańska, Wino J. Wijnen, Martina Zarak‐Crnkovic et autres

Th1 and Th17 cell-mediated autoimmunity is critical for myocarditis induction. Antigen-presenting cell (APCs)-released interleukin (IL)-12 and IL-23 are implicated in the differentiation of Th1 and Th17 lineages. In this study, we utilized cardiac self-antigen myosin heavy chain alpha (α-MyHC)-pulsed bone marrow-derived dendritic …

ch, pl, gb (code pays fourni par la source)

MiR30‐GALNT1/2 Axis‐Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts

Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Aoi Fujishima et autres

BACKGROUND: Recent studies have shown that plasma levels of the biologically inactive prohormone for brain natriuretic peptide (proBNP) are increased in patients with heart failure. This can contribute to a reduction in the effectiveness of circulating BNP and exacerbate heart failure progression. …

jp, nl (code pays fourni par la source)

Regulation of cardiac form and function: small RNAs and large hearts

Wino J. Wijnen

Heart failure, and the cardiac hypertrophy with which it is often associated, is putting an increasing burden on our healthcare system, and its prevalence is rising. Unfortunately the only available treatments are mainly targeting the symptoms, not the underlying cause of disease. …

The microRNA-15 family inhibits the TGFβ-pathway in the heart

Anke J. Tijsen, Ingeborg van der Made, Maarten M.G. van den Hoogenhof, Wino J. Wijnen et autres

AIMS: The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis, which contributes to the development of heart failure. Signalling via the TGFβ-pathway is crucial for this remodelling. Here we tested the hypothesis that microRNAs in the overloaded heart regulate this remodelling …

nl (code pays fourni par la source)

Cardiomyocyte-Specific miRNA-30c Over-Expression Causes Dilated Cardiomyopathy

Wino J. Wijnen, Ingeborg van der Made, Stephanie van den Oever, Monika Hiller et autres

MicroRNAs (miRNAs) regulate many aspects of cellular function and their deregulation has been implicated in heart disease. MiRNA-30c is differentially expressed in the heart during the progression towards heart failure and in vitro studies hint to its importance in cellular physiology. As …

nl (code pays fourni par la source)

Abstract 066: MEF2-induced Loss of Sarcomeres is Mediated by an Alternative Splice Variant of DMPK

Ies Elzenaar, Inge van der Made, Wino J. Wijnen, Elisabeth Ehler et autres

The pathology of heart failure is characterized by poorly contracting and dilated ventricles. Although this is associated with lengthening of individual cardiomyocytes and loss of sarcomeres, the mechanism underlying these changes in cardiomyocyte structure remains to be elucidated. We have previously identified …

nl, gb, fi (code pays fourni par la source)

The Therapeutic Potential of miRNAs in Cardiac Fibrosis: Where Do We Stand?

Wino J. Wijnen, Yigal M. Pinto, Esther E. Creemers

nl (code pays fourni par la source)

CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes

Yeliz Angın, Laura K.M. Steinbusch, Peter J. Simons, Sabrina Greulich et autres

An increased cardiac fatty acid supply and increased sarcolemmal presence of the long-chain fatty acid transporter CD36 are associated with and contribute to impaired cardiac insulin sensitivity and function. In the present study we aimed at preventing the development of insulin resistance …

nl, de (code pays fourni par la source)

Repression of Cardiac Hypertrophy by KLF15: Underlying Mechanisms and Therapeutic Implications

Joost J. Leenders, Wino J. Wijnen, Ingeborg van der Made, Monika Hiller et autres

The Kruppel-like factor (KLF) family of transcription factors regulates diverse cell biological processes including proliferation, differentiation, survival and growth. Previous studies have shown that KLF15 inhibits cardiac hypertrophy by repressing the activity of pivotal cardiac transcription factors such as GATA4, MEF2 and …

nl, be (code pays fourni par la source)

Poster session 3

Ondřej Naňka, Éric Krejci, Z. Pesevski, David Sedmera et autres

Fibroblast growth factors (FGFs) and their receptors play an important role during embryonic induction and patterning, as well as in modulating proliferative and hypertrophic growth in fetal and adult organs.Exogenous FGF2 (also known as basic FGF) was found to be able to …

in, at, cz, nl, pl, gb, by, ie (code pays fourni par la source)

Variants in the 3′ untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner

Ahmad S. Amin, John R. Giudicessi, Anke J. Tijsen, Anne Mea Spanjaart et autres

AIMS: Heterozygous mutations in KCNQ1 cause type 1 long QT syndrome (LQT1), a disease characterized by prolonged heart rate-corrected QT interval (QTc) and life-threatening arrhythmias. It is unknown why disease penetrance and expressivity is so variable between individuals hosting identical mutations. We …

nl, us, de (code pays fourni par la source)

Differential regulation of cardiac GLUT4-mediated glucose and CD36-mediated fatty acid uptake by endosomal pH and actin filaments

Laura K.M. Steinbusch, Wino J. Wijnen, Robert Wolfgang Schwenk, Will A. Coumans et autres

nl, de, vn, ca (code pays fourni par la source)