Oliver Borst

IL-4 and GPVI: a new bond restricting thromboinflammation?

Patrick Münzer, Oliver Borst

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Synergistic modulation of cAMP and cGMP rescues hemin-induced plasma membrane fragmentation

Zoi Laspa, Anne‐Katrin Rohlfing, Melina Fischer, Ferdinand Kollotzek et autres

Hemin, which gets released during erythrocyte lysis, induces concentration-dependent platelet activation, aggregation, and thrombus formation as well as plasma membrane destruction and cytoskeleton reorganization. Classical platelet antagonists do not inhibit the plasma membrane destruction induced by high concentrations of hemin. Both cyclic …

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Endomyocardial Gremlin-1 is associated with structural remodeling and adverse clinical outcomes in non-ischemic cardiomyopathy

Tobias Harm, Karin Klingel, Patrick Krumm, David Heinzmann et autres

BACKGROUND: Risk stratification in non-ischemic cardiomyopathies (NICM) remains challenging despite guideline-based phenotypic classification using multimodal diagnostics including endomyocardial biopsy (EMB). We aimed to identify EMB-derived histological and molecular markers that improve phenotypic characterization and long-term risk stratification in patients with NICM. METHODS: …

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Dynamic neutrophil lipidome remodeling during induction of NETosis

Patrick Münzer, Cristina Coman, Gundula D. Lingens, Nina Troppmair et autres

Neutrophil extracellular trap formation (NETosis) affects a wide variety of clinically relevant human diseases. Although lipid remodeling is essential for neutrophil function and membrane rupture during NETosis, the neutrophil lipidome and its dynamics have not been characterized. Thus, we establish a quantitative …

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Enhancing cardiac ablation efficacy with electroporation-assisted intracellular delivery of the ribosome-inactivating protein gelonin

Pamela W. Sowa, Wojciech Szlasa, Aleksander Kielbik, Anne‐Katrin Rohlfing et autres

Achieving complete cardiac ablation requires higher electric fields, increasing the risk of vasospasm or collateral injury. A potential strategy to enhance ablation efficacy without raising field strength is selective pharmacological targeting of reversibly electroporated cells. Gelonin, a type I ribosome-inactivating protein, inhibits …

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T-cell activation and fibroblastic BMP4-Gremlin dysregulation indicate disease severity in acute myocarditis

Anna Joachimbauer, Christian Ivan Perez-Shibayama, Emily Payne, Isabella Hanka et autres

Abstract Background and Aims Acute myocarditis (AM) is a T cell-mediated myocardial disease with clinical manifestations ranging from mild chest pain to cardiogenic shock. Reliable biomarkers to stratify patients and guide therapy are currently lacking. In particular, the extent of the dysregulation …

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Slick K+ channels contribute to cardiac remodeling, fibrosis, and dysfunction in postinfarction hearts

Jiaqi Yang, Lin Zhu, David Spähn, Melanie Cruz Santos et autres

Resident cardiac fibroblast-derived (RCF-derived) cardiac myofibroblasts (CMFs) contribute to myocardial repair but also drive adverse ventricular remodeling and contractile dysfunction after myocardial infarction (MI). The sodium-activated potassium channel Slick (Slo2.1) has been described in cardiomyocyte (CM) mitochondria; however, transcriptomic analyses indicate higher …

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Acetylsalicylic acid improves outcome after acute myocardial infarction by reducing thromboinflammation

Carolin Helten, Marcel Benkhoff, Philipp Mourikis, Daniel Metzen et autres

BACKGROUND: Inflammation orchestrates an outcome after acute myocardial infarction (AMI). Thromboinflammation, via the CD40- and CD40 ligand (CD40L)-mediated platelet-leukocyte interaction, is involved in post-AMI inflammation. OBJECTIVES: This study hypothesized that acetylsalicylic acid (ASA) exerts pleiotropic cardioprotective effects beyond prevention of reinfarction by …

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Development of an integrated clinical-laboratory scoring system for accurate HIT diagnosis

Günalp Uzun, Sergio Origel Romero, J. Zlámal, Johann Jacoby et autres

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Platelet Casein Kinase 2α is a pivotal player in arterial thrombotic occlusion and post-ischemic myocardial remodeling

Melina Fischer, Manuel Sigle, Mailin-Christin Manke, Julia Marzi et autres

AIMS: Platelets play a major role in thrombo-inflammatory cardiovascular diseases such as myocardial infarction. Although platelet function is crucially determined by kinases, the impact of Casein Kinase 2α (CK2α) on platelet activation during arterial thrombosis and myocardial remodeling following ischemia and reperfusion …

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Prolonged ischemia induces oxidative stress, affects extra cellular matrix gene expression and compromises the viability of cancellous bone grafts

Maximilian M. Menger, Tina Histing, Franziska Poeske, Lina P. Schäfer et autres

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Targeted inhibition of ELANE expression using adenine base editing to treat severe congenital neutropenia

Betül Fındık, Benjamin Dannenmann, Frank Bernhard, Masako Monika Kaufmann et autres

mutation heterogeneity.

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