Gaëlle Lefolgoc

PFMG2025–integrating genomic medicine into the national healthcare system in France

Caroline Abadie, Aldja Abderrahmane, Ouarda Abdous, Carine Abel et autres

Integrating genomic medicine into healthcare systems is a health policy challenge that requires continuously transferring scientific advances into clinics and ensuring equal access for patients. France was one of the first countries to integrate genome sequencing into clinical practice at a nationwide …

Méthodes de partitionnements pour détecter des structures fines de population et applications au projet POPGEN

Guivrach Mael, Gaëlle Lefolgoc, Gaëlle Marenne, Thomas Ludwing et autres

International audience

fr (code pays fourni par la source)

Evaluation of saliva as a source of accurate whole‐genome and microbiome sequencing data

Anthony F. Herzig, Lourdes Velo‐Suárez, Gaëlle Lefolgoc, Anne Boland et autres

This study sets out to establish the suitability of saliva-based whole-genome sequencing (WGS) through a comparison against blood-based WGS. To fully appraise the observed differences, we developed a novel technique of pseudo-replication. We also investigated the potential of characterizing individual salivary microbiomes …

fr, am (code pays fourni par la source)

Evaluation of saliva as a source of accurate whole-genome and microbiome sequencing data

Anthony F. Herzig, Lourdes Velo‐Suárez, Gaëlle Lefolgoc, Anne Boland et autres

Abstract This study sets out to establish the suitability of saliva-based whole-genome sequencing (WGS) through a comparison against blood-based WGS. To fully appraise the observed differences, we developed a novel technique of pseudo-replicates. We also investigated the potential of characterising individual salivary …

fr (code pays fourni par la source)

Hepatocellular carcinoma recurrence in hepatitis C virus-related cirrhosis treated with direct-acting antivirals: a case–control study

Xavier Adhoute, Guillaume Pénaranda, Jean‐Luc Raoul, Floriane Sellier et autres

BACKGROUND: Direct-acting antivirals (DAAs) therapy against hepatitis C viral (HCV) infection has markedly improved the sustained viral response. However, recent studies have suggested an unsuspected high rate of hepatocellular carcinoma (HCC) recurrence. PATIENTS AND METHODS: A retrospective case-control study was carried out …

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NIACE score for hepatocellular carcinoma patients treated by surgery or transarterial chemoembolization

Xavier Adhoute, Guillaume Pénaranda, Jean‐Luc Raoul, Emilie Bollon et autres

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) prognostic scores could be useful in addition to the Barcelona Clinic Liver Cancer (BCLC) system to clarify patient prognosis and guide treatment decision. The NIACE (tumor Nodularity, Infiltrative nature of the tumor, serum Alpha-fetoprotein level, Child-Pugh …

fr (code pays fourni par la source)

Retreatment of hepatitis C virus daa failures in real life: easy and difficult to cure patients

Denis Ouzan, Guillaume Pénaranda, Gaëlle Lefolgoc, M. Antoni et autres

P0376 : Stratification of hepatocellular carcinoma. The prognostic score NIACE, an additional aid to the Barcelona Clinic Liver Cancer (BCLC) staging system? Multicenter study

Xavier Adhoute, Guillaume Pénaranda, Jean F. Blanc, Julien Edeline et autres

fr (code pays fourni par la source)

Optimal therapy of genotype‐2 chronic hepatitis C: what's new?

Marc Bourlière, Souâd Benali, Christelle Ansaldi, Gaëlle Lefolgoc et autres

The standard of care (SOC) for the treatment of HCV genotype 2 (HCV-2) was pegylated interferon alpha plus ribavirin (PEG-IFN/RBV) at weight-based doses for a response-guided duration. The launches of sofosbuvir and daclatasvir in 2014 have resulted in new, better tolerated and …

fr (code pays fourni par la source)

Retreatment with TACE: The ABCR SCORE, an aid to the decision-making process

Xavier Adhoute, Guillaume Pénaranda, Sébastien Naudé, Jean‐Luc Raoul et autres

fr (code pays fourni par la source)

P976 RETREATMENT WITH TRANSARTERIAL CHEMOEMBOLIZATION (TACE): THE ABCR SCORE, AN AID TO THE DECISION-MAKING PROCESS

Xavier Adhoute, Guillaume Pénaranda, Jean‐Luc Raoul, J.-P. Bronowicki et autres

P977 UNRESECTABLE HEPATOCELLULAR CARCINOMA (HCC) TREATED BY TRANSARTERIAL CHEMOEMBOLIZATION (TACE): AFTER TWO SESSIONS, ART OR ABCR SCORES TO GUIDE THE DECISION MAKING PROCESS?

Xavier Adhoute, Guillaume Pénaranda, Jean‐Luc Raoul, Patrizia Castellani et autres