Lina Hountondji

SAT-068 Long-term outcomes following checkpoint inhibitor-induced liver injury

Kenza Faouzi, Alexandre Maria, Stéphanie Faure, C. Lesage et autres

SAT-076 Impact of liver biopsy on causality assessment in checkpoint inhibitor–induced liver injury

Lucy Meunier, Alexandre Maria, Benjamin Rivière, Bénédicte Delire et autres

Plasma exchange as potential treatment of severe immune checkpoint inhibitor-induced hepatitis

Lucy Meunier, Clément Monet, Antonio Saviano, Marwin A. Farrugia et autres

Background & Aims: Immune checkpoint inhibitors (ICIs) improve cancer survival but can cause severe immune-related hepatitis. Standard therapy with corticosteroids and second-line agents such as mycophenolate mofetil fails in some cases. Therapeutic plasma exchange (TPE) has been suggested as rescue therapy, but …

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Features and Outcomes of 280 Patients With Idiosyncratic Drug-Induced Liver Injury: The REFHEPS Prospective Study

Lucy Meunier, Bénédicte Delire, Eléonora De Martin, Fanny Lebossé et autres

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Pré-test

Lucy Meunier, Kenza Faouzi, Margaux Delhomme, Lina Hountondji

Cirrhosis alters drug metabolism, making prescribing complex and sometimes high-risk. Multiple pharmacokinetic mechanisms are affected by the disease, resulting in reduced hepatic clearance, changes in hepatic extraction, hypoalbuminemia, and impaired enzymatic metabolism. The consequences vary depending on drug characteristics such as therapeutic …

Ursodeoxycholic Acid: Not Just a Marker, but a Therapeutic Opportunity in Cholestatic CHILI

Lina Hountondji, Lucy Meunier

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

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Nicotine dependence of arrestees kept in French police cells

Vianney Gandon, Lina Hountondji, Roxane Tahtah, Thomas Lefèvre et autres

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THU-352 The histological activity index is associated with disease severity and treatment response in patients with immune mediated liver injury from checkpoint inhibitors

Robert J. Fontana, Lucy Meunier, David E. Kleiner, Benjamin Rivière et autres

Ursodeoxycholic Acid Alone Is Effective and Safe to Treat Cholestatic Checkpoint Inhibitor‐Induced Liver Injury

Lina Hountondji, Stéphanie Faure, Pascale Palassin, Georges‐Philippe Pageaux et autres

INTRODUCTION: Checkpoint Inhibitor-induced Liver Injury (CHILI) is a frequent complication of immune checkpoint inhibitors (ICIs). Corticosteroids are the standard treatment but have many limitations. Ursodeoxycholic acid (UDCA) offers an alternative for managing cholestatic CHILI, but its efficacy remains underexplored. METHODS: A multicenter …

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Editorial: Checkpoint Inhibitor‐Induced Liver Injury—Time to Abandon CTCAE ? Authors' Reply

Lina Hountondji, Lucy Meunier

International audience

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Time to use the right classification to predict the severity of checkpoint inhibitor‐induced liver injury, as assessed for causality using the updated RUCAM

Lina Hountondji, Stéphanie Faure, Pascale Palassin, Philine Witkowski Durand Viel et autres

BACKGROUND AND AIMS: While immune checkpoint inhibitors (ICIs) are revolutionising cancer therapy, checkpoint inhibitor-induced liver injury is a significant immune-related side effect of this immunotherapy. This study focuses on the severity classifications and characteristics of patients with checkpoint inhibitor-induced hepatitis. METHODS: A …

fr (code pays fourni par la source)

SAT-306 Time to use the right classification to predict the severity of checkpoint inhibitor-induced liver injury

Lina Hountondji, Stéphanie Faure, Pascale Palassin, PhilineWitkowski Durand Viel et autres