Anika Nier

FRI-419 Beyond status markers: profound disruption of vitamin d metabolism in decompensated cirrhosis and its clinical implications

Anika Nier, Julia Kühn, Stefanie Quickert, Christian Weißenborn et autres

Fructose intake enhances lipoteichoic acid-mediated immune response in monocytes of healthy humans

Raphaela Staltner, Katja Csarmann, Anika Nier, Anja Baumann et autres

Metabolic diseases like type 2 diabetes are afflicted with higher rates of infections and longer, more complicated infection course as well as higher fatality rates. The impact of nutrition and specific nutrients like free fructose herein has not yet been fully understood. …

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Vitamin D metabolism is changed and FGF23 levels are increased in patients with cirrhosis

Anika Nier, Julia Kühn, Alexander Kluttig, Rafael Mikolajczyk et autres

Background: Vitamin D (VD) deficiency, assessed by plasma 25-Hydroxyvitamin-D (25(OH)D), is highly prevalent in chronic liver disease (CLD) and associated with disease progression and complications. However, the variable response of individuals to VD supplementation indicates the limitation of 25(OH)D levels to provide …

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Effects of a single phosphate-enriched test meal on inflammasome activity and postprandial inflammatory markers in healthy subjects

Anika Nier, Christof Ulrich, Christin Volk, Marie-Charlotte Wolffgang et autres

PURPOSE: The consumption of highly processed food is often associated with a high intake of inorganic phosphate. Hyperphosphatemia is accompanied by an inflammatory status in patients with chronic kidney disease. However, the immune response to high phosphorus intake in healthy individuals is …

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Dietary cholesterol increases body levels of oral administered vitamin D3 in mice

Julia Kühn, Alexandra Schutkowski, Lina-Maria Rayo-Abella, Mikis Kiourtzidis et autres

Abstract Vitamin D and cholesterol share the same intestinal transporters. Thus, it was hypothesized that dietary cholesterol adversely affects vitamin D uptake. The current studies investigated the influence of cholesterol on the availability of oral vitamin D. First, 42 wild-type mice received …

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Short-term intake of fiber-rich oat bran but not spelt bran flake mix lowers bacterial endotoxin levels and improves health parameters in healthy, normal weight, young to middle-aged women

Annette Brandt, Angélica María Hernández-Arriaga, Timur Yergaliyev, Anika Nier et autres

Diets low in dietary fiber have been associated with higher risks for non-communicable chronic diseases. We assessed in a single-blinded cross-over designed study if oat bran and spelt bran rich flake mixes, respectively, are suitable to increase general fiber intake in healthy …

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Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and ‘inflammaging'

Annette Brandt, Anja Baumann, Angélica María Hernández-Arriaga, Finn Jung et autres

Aging is considered a state of low grade inflammation, occurring in the absence of any overt infection often referred to as 'inflammaging'. Maintaining intestinal homeostasis may be a target to extend a healthier status in older adults. Here, we report that even …

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Microalgae-derived sterols do not reduce the bioavailability of oral vitamin D3 in mice

Julia Kühn, Corinna Brandsch, Mikis Kiourtzidis, Anika Nier et autres

Abstract: Microalgae have drawn increasing attention as sustainable food sources, also because of their lipid-lowering phytosterols. As phytosterols are also discussed critically regarding their effect on the availability of fat-soluble vitamins, this study aimed to investigate microalgae-derived phytosterols and their effect on …

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Alterations of nitric oxide homeostasis as trigger of intestinal barrier dysfunction in non‐alcoholic fatty liver disease

Anja Baumann, Dragana Rajcic, Annette Brandt, Victor Hugo Saucedo Sanchez et autres

Abstract Changes in intestinal nitric oxide metabolism are discussed to contribute for the development of intestinal barrier dysfunction in non‐alcoholic fatty liver disease (NAFLD). To induce steatosis, female C57BL/6J mice were pair‐fed with a liquid control diet (C) or a fat‐, fructose‐ …

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Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease

Anja Baumann, Anika Nier, Angélica María Hernández-Arriaga, Annette Brandt et autres

Abstract Toll-like receptors (TLRs) in the liver compartment have repeatedly been attributed to the development of non-alcoholic fatty liver disease (NAFLD). Knowledge on TLR expression in blood cells and their relation to intestinal microbiota and NAFLD development is limited. Here, we determined …

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Microbiota profiling in aging-associated inflammation and liver degeneration

Anja Baumann, Angélica María Hernández-Arriaga, Annette Brandt, Victor Hugo Saucedo Sanchez et autres

BACKGROUND: The number of people above the age of 60 years is raising world-wide being associated with an increase in the prevalence of aging-associated impairments and even diseases. Recent studies suggest that aging is associated with alterations in bacterial endotoxin levels and …

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Fortifying Butterfat with Soybean Oil Attenuates the Onset of Diet-Induced Non-Alcoholic Steatohepatitis and Glucose Intolerance

Victor Hugo Saucedo Sanchez, Annette Brandt, Cheng Jun Jin, Dragana Rajcic et autres

The addition of plant oils such as soybean oil (S) to a diet rich in saturated fatty acids is discussed as a possible route to prevent or diminish the development of metabolic disease. Here, we assessed whether a butterfat-rich diet fortified with …

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