Andrew Gratrix

Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients

DANIEL S. MARTIN, Doug William Gould, Tasnin Shahid, James Doidge et autres

Importance: Supplemental oxygen is frequently given to patients in intensive care units (ICUs); however, there is insufficient evidence to guide its therapeutic use and to minimize the potential harm caused by administering too little or too much. Objective: To determine whether reducing …

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A survey of the workload generated by older surgical patients referred to on-call medical registrars—SNAP-3

Claire Jane Swarbrick, Dermot Moloney, Tamsin Gregory, Mark S. MACGREGOR et autres

Background: Older surgical patients who develop medical problems are commonly referred to medical teams, which can be proactive physician-led teams or through reactive referral to the on-call medical registrar. Methods: A cross-sectional survey of on-call medical registrars who received referrals from surgical …

gb, us, au, ca (code pays fourni par la source)

The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study

Kirsty C. McGee, Md. Anower Hossain, Gavin D. Perkins, Anthony C. Gordon et autres

PURPOSE: The landiolol and organ failure in patients with septic shock (STRESS-L study) included a pre-planned sub-study to assess the effect of landiolol treatment on inflammatory and metabolomic markers. METHODS: Samples collected from 91 patients randomised to STRESS-L were profiled for immune …

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Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan et autres

Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited.Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and …

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Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis

Joel M. Dulhunty, Stephen James Brett, Jan J. De Waele, Dorrilyn Rajbhandari et autres

Importance: Whether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain. Objective: To evaluate whether continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) results in decreased all-cause mortality …

au, gb, be, nz, sg, fr (code pays fourni par la source)

A second update on mapping the human genetic architecture of COVID-19

Shea J. Andrews, Mattia Cordioli, Christine R. Stevens, Mark J. Daly et autres

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1 , 2 . Here we present a second updated genome-wide association study (GWAS) …

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Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.

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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation, we have shown that …

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Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, Alex Stuckey et autres

after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically …

gb, au, cn, ca, ie, us, hk, Ouganda, br (code pays fourni par la source)

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

Chiara Fallerini, Nicola Picchiotti, Margherita Baldassarri, Kristina Zguro et autres

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 …

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Mapping the human genetic architecture of COVID-19

Mari Niemi, Juha S. Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …

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Postoperative critical care and high-acuity care provision in the United Kingdom, Australia, and New Zealand

Danny J. N. Wong, Scott Popham, Andrew Marshall Wilson, Lisa M. Barneto et autres

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