Rolf J. Craven

Focal Adhesion Kinase Intersects With the BRD4‐MYC Axis and YAP1 to Drive Tumor Cell Growth, Phenotypic Plasticity, Stemness, and Metastatic Potential in Colorectal Cancer

Rongbo Han, Junfeng Shi, Kai Cheng, Zian Wang et autres

OBJECTIVE: Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide due to the lack of effective therapies. Here we explored the clinical basis and therapeutic promise of the integrin-focal adhesion kinase (FAK)-dependent pathway for CRC. METHODS AND RESULTS: …

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Targeting receptor tyrosine kinases in ovarian cancer: Genomic dysregulation, clinical evaluation of inhibitors, and potential for combinatorial therapies

Ying Wei, Sonia Erfani, David S. Schweer, Rafael de Gouvea et autres

Epithelial ovarian cancer (EOC) remains one of the leading causes of cancer-related deaths among women worldwide. Receptor tyrosine kinases (RTKs) have long been sought as therapeutic targets for EOC, as they are frequently hyperactivated in primary tumors and drive disease relapse, progression, …

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GAPDH in neuroblastoma: Functions in metabolism and survival

Kevin Cornett, Anna Puderbaugh, Olivia Back, Rolf J. Craven

Neuroblastoma is a pediatric cancer of neural crest cells. It develops most frequently in nerve cells around the adrenal gland, although other locations are possible. Neuroblastomas rely on glycolysis as a source of energy and metabolites, and the enzymes that catalyze glycolysis …

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Dependence of glucose transport on autophagy and GAPDH activity

Rolf J. Craven, Hilaree N. Frazier, Olivier Thibault

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Regulation of Iron Homeostasis Mediated by the Heme-binding Protein Dap1 (Damage Resistance Protein 1) via the P450 Protein Erg11/Cyp51

Rolf J. Craven, Julia C. Mallory, Randal Hand

Fungal infections arise frequently in immunocompromised patients, and sterol synthesis is a primary pathway targeted by antifungal drugs. In particular, the P450 protein Erg11/Cyp51 catalyzes a critical step in ergosterol synthesis, and the azole class of antifungal drugs inhibits Erg11. Dap1 is …

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Dual Inhibition of Focal Adhesion Kinase and Epidermal Growth Factor Receptor Pathways Cooperatively Induces Death Receptor-mediated Apoptosis in Human Breast Cancer Cells

Vita Golubovskaya, William G. Cance, Li Xu, Lucia Beviglia et autres

The focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) are protein-tyrosine kinases that are overexpressed and activated in human breast cancer. To determine the role of EGFR and FAK survival signaling in breast cancer, EGFR was stably overexpressed in BT474 …

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The Focal Adhesion Kinase Suppresses Transformation-associated, Anchorage-independent Apoptosis in Human Breast Cancer Cells: INVOLVEMENT OF DEATH RECEPTOR-RELATED SIGNALING PATHWAYS

William G. Cance, Albert S. Baldwin, Lihui Xu, Xihui Yang et autres

The focal adhesion kinase (FAK) is a mediator of cell-extracellular matrix signaling events and is overexpressed in tumor cells. In order to rapidly down-regulate FAK function in normal and transformed mammary cells, we have used adenoviral gene transduction of the carboxyl-terminal domain …

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Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis

William G. Cance, Rolf J. Craven, LiHui XU, XiHui YANG et autres

Focal adhesion kinase (FAK) has a central role in adhesion-mediated cell signalling. The N-terminus of FAK is thought to function as a docking site for a number of proteins, including the Src-family tyrosine kinases. In the present study, we disrupted FAK signalling …

BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways

Yang Zhang, Bingwei Xu, Junfeng Shi, Jieming Li et autres

Abstract Purpose Stemming from a myriad of genetic and epigenetic alterations, triple-negative breast cancer (TNBC) is tied to poor clinical outcomes and aspires for individualized therapies. Here we investigated the therapeutic potential of co-inhibiting integrin-dependent signaling pathway and BRD4, a transcriptional and …

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Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons

Hilaree N. Frazier, Adam O. Ghoweri, Katie L. Anderson, Ruei‐Lung Lin et autres

Insulin signaling is an integral component of healthy brain function, with evidence of positive insulin-mediated alterations in synaptic integrity, cerebral blood flow, inflammation, and memory. However, the specific pathways targeted by this peptide remain unclear. Previously, our lab used a molecular approach …

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Bożena Gabryel, Hkw Law, Angelo De Milito, Jason E. Gestwicki et autres

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A Case Study of Precision Medicine: Next Generation Sequencing Compared with Oncoscan in a Patient with Breast Cancer in Kentucky

Rolf J. Craven, Kuey-Chu Chen, Steven R. Schwarze, Sydney Lay et autres

Purpose: Precision medicine of tumors is designed to tailor treatment combinations to individual patients, targeting specific genotypes with corresponding inhibitors. The purpose of this study was to determine whether genotype predicted target gene expression-a critical parameter for treatment-and to test whether alternate …