Yulia Sidorova

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach, Denzil Bernard, Kong T. Nguyen, Gregory Ho et autres

As a result, the correct Affiliation for Andrew B. Herr, Benjamin Liou, David A. Hildeman, Joseph J. Maciag, Ying Sun, Durga Krishnamurthy, and Stephen N. Waggoner is:

us, br, sg, au, ca, nl, ch, be, it, gb, es (code pays fourni par la source)

AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach, Denzil Bernard, Kong T. Nguyen, Gregory Ho et autres

High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy …

us, br, sg, au, ca, nl, ch, be, it, gb, es (code pays fourni par la source)

The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord

Fredrik Ahlström, Hanna Viisanen, Leena Karhinen, Kert Mätlik et autres

Background: Opioids are efficacious and safe analgesic drugs in short-term use for acute pain but chronic use can lead to tolerance and dependence. Opioid-induced microglial activation may contribute to the development of tolerance and this process may differ between males and females. …

fi (code pays fourni par la source)

A Newly Identified Monoterpenoid-Based Small Molecule Able to Support the Survival of Primary Cultured Dopamine Neurons and Alleviate MPTP-Induced Toxicity In Vivo

Анастасия Котлярова, Alexandra V. Podturkina, А.В. Павлова, Daria S. Gorina et autres

Parkinson’s disease (PD) is the most common age-related movement disorder characterized by the progressive loss of nigrostriatal dopaminergic neurons. To date, PD treatment strategies are mostly based on dopamine replacement medicines, which can alleviate motor symptoms but do not slow down the …

fi, ru (code pays fourni par la source)

Biological Activity In Vitro , Absorption, BBB Penetration, and Tolerability of Nanoformulation of BT44:RET Agonist with Disease-Modifying Potential for the Treatment of Neurodegeneration

Malik Salman Haider, Arun Kumar Mahato, Анастасия Котлярова, Stefan Forster et autres

High Resolution Image Download MS PowerPoint Slide BT44 is a novel, second-generation glial cell line-derived neurotropic factor mimetic with improved biological activity and is a lead compound for the treatment of neurodegenerative disorders. Like many other small molecules, it suffers from intrinsic …

de, fi (code pays fourni par la source)

Biological activity In vitro, absorption, BBB penetration and tolerability of nanoformulation of BT44, a RET agonist with disease-modifying potential for the treatment of neurodegeneration

Malik Salman Haider, Arun Kumar Mahato, Анастасия Котлярова, Stefan Förster et autres

BT44 is a novel, second generation glial cell line-derived neurotropic factor (GDNF) mimetic, with improved biological activity and a lead compound for the treatment of neurodegenerative disorders. Like many other small molecules, it suffers from intrinsic poor aqueous solubility, posing significant hurdles …

fi, de (code pays fourni par la source)

Neurotrophic Factors to Combat Neurodegeneration

Yulia Sidorova

Conditions caused by the lesion and progressive death of neuronal cells in the organism include neurodegenerative disorders and neuropathic pain. They represent the major causes of disability in Western countries. These conditions are more common in elderly people, and their prevalence, therefore, …

Hypoglycemic Effects of Polyphenol Complexes from Bilberry Leaves and Fruits Sorbed on Brown Buckwheat Flour -- Experimental Evaluation and Prospects of Use

N A Petrov, Yulia Sidorova, А А Кочеткова, V K Mazo

The effects of plant polyphenols on carbohydrate and/or lipid metabolism disorders have wide experimental and clinical justification; however, their effects are limited due to low bioavailability. Thus, the development of technological approaches enhancing their effectiveness and stability is relevant.The aim of this …

ru (code pays fourni par la source)

Biological activity In vitro, absorption, BBB penetration and toxicity of nanoformulation of BT44, a RET agonist with disease-modifying potential for the treatment of neurodegeneration

Malik Salman Haider, Arun Kumar Mahato, Анастасия Котлярова, Stefan Forster et autres

BT44 is a novel, second generation glial cell line-derived neurotropic factor (GDNF) mimetic, with improved biological activity and a lead compound for the treatment of neurodegenerative disorders. Like many other small molecules, it suffers from intrinsic poor aqueous solubility, posing significant hurdles …

fi, de (code pays fourni par la source)

Biological activity In vitro, absorption, BBB penetration and toxicity of nanoformulation of BT44, a RET agonist with disease-modifying potential for the treatment of neurodegeneration

Malik Salman Haider, Arun Kumar Mahato, Анастасия Котлярова, Stefan Förster et autres

BT44 is a novel, second generation glial cell line-derived neurotropic factor (GDNF) mimetic, with improved biological activity and a lead compound for the treatment of neurodegenerative disorders. Like many other small molecules, it suffers from intrinsic poor aqueous solubility, posing significant hurdles …

fi, de (code pays fourni par la source)

Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats

Fredrik Ahlström, Kärt Mätlik, Hanna Viisanen, Kim Blomqvist et autres

Neuropathic pain is more prevalent in women. However, females are under-represented in animal experiments, and the mechanisms of sex differences remain inadequately understood. We used the spared nerve injury (SNI) model in rats to characterize sex differences in pain behaviour, unbiased RNA-Seq …

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Glial Cell Line-Derived Neurotrophic Factor Family Ligands, Players at the Interface of Neuroinflammation and Neuroprotection: Focus Onto the Glia

Анастасия Котлярова, Yulia Sidorova

Well-known effects of neurotrophic factors are related to supporting the survival and functioning of various neuronal populations in the body. However, these proteins seem to also play less well-documented roles in glial cells, thus, influencing neuroinflammation. This article summarizes available data on …

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