Dale M. Kobrin

Examination of HLA-DRB1*15–linked Candidate Antigens in Still Disease With and Without Lung Disease and Drug-Associated Immune Reactions

Dale M. Kobrin, David Garrett Brown, Peter D. Burbelo, Lisa J. Workman et autres

Objective Lung disease (LD) in systemic juvenile idiopathic arthritis and adult-onset Still disease (Still-LD) is a severe manifestation strongly associated with HLA-DRB1*15 alleles and drug-associated immune reactions (DAIR), including eosinophilia, non–Still disease rashes, and elevated liver function tests. Despite the high morbidity …

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A comprehensive review of dermatomyositis treatments - from rediscovered classics to promising horizons

Ecem Sevim, Dale M. Kobrin, María Casal-Domínguez, Iago Pinal‐Fernandez

INTRODUCTION: Dermatomyositis (DM) is a rare inflammatory disease with diverse cutaneous and systemic manifestations, often associated with myositis-specific antibodies. Managing patients with refractory DM, or individuals presenting pecific complications, like calcinosis or rapidly progressive interstitial lung disease, presents unique challenges. AREAS COVERED: …

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Successful Treatment of Paecilomyces variotii Pneumonia and Lupus Nephritis With Posaconazole-Cyclophosphamide Co-administration Without Drug Interaction–Induced Toxicity

Joseph Pechacek, Taura Webb, Elise M. N. Ferré, Monica M. Schmitt et autres

Abstract Paecilomyces variotii is an opportunistic mold that causes pulmonary infections in immunosuppressed humans that are often treated with triazole therapy. Lupus nephritis is a major cause of progressive kidney disease in patients with systemic lupus erythematosus, often requiring cyclophosphamide-based therapies. Triazole-cyclophosphamide …

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Treatment of Immune-Mediated Necrotizing Myopathy

Sandra Amara Ogbonnaya-Whittlesey, Dale M. Kobrin, María Casal-Domínguez, Andrew Lee Mammen et autres

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Relapsing polychondritis: Best Practice & Clinical Rheumatology

Phillip Mertz, Joshua D. Sparks, Dale M. Kobrin, Sandra Amara Ogbonnaya et autres

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Membranoproliferative Glomerulonephritis (MPGN) in the Setting of Unicentric Castleman Disease

Ali W. Rizvi, Dale M. Kobrin, Naman Gupta, Michael Turk et autres

Introduction: Castleman’s disease (CD) is a rare lymphoproliferative disorder with histopathological abnormalities - divided primarily into unicentric and multicentric disease. Thought to be an inflammatory process, renal involvement has been described extensively in the setting of multicentric disease, especially associated with HHV-8. …

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Coincidence or connection? A patient with concurrent Lane Hamilton Syndrome and idiopathic membranous nephropathy

Scarlett Austin, Dale M. Kobrin, Vipin D. Villgran, Michael Nestasie et autres

Lane Hamilton Syndrome is the rare association of idiopathic pulmonary hemosiderosis and Celiac Disease. The definitive pathophysiologic link is unknown, but the syndrome has been described as co-occurring along with other diseases. We describe the first reported case of Lane Hamilton Syndrome …

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Increased mTOR activation in idiopathic multicentric Castleman disease

Daniel Jose Arenas, Katherine Floess, Dale M. Kobrin, Ruth-Anne Langan Pai et autres

Idiopathic multicentric Castleman disease (iMCD) is a rare and poorly understood hematologic disorder characterized by lymphadenopathy, systemic inflammation, cytopenias, and life-threatening multiorgan dysfunction. Interleukin-6 (IL-6) inhibition effectively treats approximately one-third of patients. Limited options exist for nonresponders, because the etiology, dysregulated cell …

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Castleman Disease

Dale M. Kobrin, David C. Fajgenbaum

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Increased mTOR activation in idiopathic multicentric Castleman disease

Daniel Jose Arenas, Katherine Floess, Dale M. Kobrin, Maya Blanka Srkalovic et autres

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Letter to the editor regarding ‘Non-cirrhotic portal hypertension associated with multicentric Castleman's disease: a case report’

Dale M. Kobrin, Ana Luísa Pinto, Sophia A. T. Parente, Marília Gomes et autres

Idiopathic multicentric Castleman disease (iMCD) is a rare inflammatory condition characterized by multiple regions of enlarged lymph nodes that demonstrate characteristic histopathology and cytoki...

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Pi3k/Akt/Mtor Pathway Activity Is Increased in Lymph Node Tissue from Idiopathic Multicentric Castleman Disease Patients with Tafro Syndrome

Dustin J. Shilling, Dale M. Kobrin, David C. Fajgenbaum

Abstract Castleman disease (CD) describes a group of heterogeneous diseases defined by shared lymph node histopathology, including atrophic or hyperplastic germinal centers, prominent follicular dendritic cells, hypervascularization, polyclonal lymphoproliferation, and/or polytypic plasmacytosis. Unicentric CD (UCD) involves a solitary enlarged lymph node that …

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