Michele Casale

HCV treatment in Sardinian HIV-HCV coinfected patients: a real-life perspective study on safety, efficacy, and immune reconstitution

Francesco Pes, Simona Onali, Cinzia Balestrieri, Goffredo Angioni et autres

BACKGROUND: HIV-HCV co-infected patients have long been considered difficult-to-treat. The introduction of direct-acting antivirals (DAAs) changed this paradigm.We evaluated the efficacy and safety of DAA-based regimens and the impact of DAAs-induced HCV clearance on the immunological status in HIV-HCV co-infected patients. RESEARCH …

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THU-463-Role of natural killer cells receptors on the development and progression of hepatocellular carcinoma

Francesco Figorilli, Cristina Manieli, Simona Onali, Michele Casale et autres

IMPACT OF KILLER-CELL IMMUNOGLOBULIN-LIKE RECEPTORS ON PROGRESSION OF HEPATOCELLULAR CARCINOMA

Roberto Littera, Luchino Chessa, Andrea Perra, Sara Lai et autres

Safety and Efficacy of Direct-Acting Antivirals in Transfusion-Dependent Thalassemic Patients with Chronic Hepatitis C

Simona Onali, Ivana Rita Maida, Cinzia Balestrieri, Francesco Arcadu et autres

Background: Hepatitis C virus (HCV) infection is a major cause of liver-related morbidity and mortality among thalassemic patients. New treatments based on direct-acting antivirals (DAAs) are highly effective and well-tolerated by patients; nonetheless, they have not been studied in thalassemic populations. In …

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Impact of natural killer (NK) cells receptors gene haplotypes on the development of hepatocarcinoma in cirrhotic patients

Simona Onali, Roberto Littera, Michele Casale, Francesca Capraro et autres

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Impact of natural killer cells receptors gene haplotypes on the development of hepatocarcinoma in cirrhotic patients

Sara Onali, Roberto Littera, Michele Casale, Francesca Capraro et autres

Efficacy and tolerability of treatment with the new direct acting antivirals (DAAs) in thalassemic patients with chronic Hepatitis

Simona Onali, Ivana Rita Maida, Cinzia Balestrieri, Francesco Arcadu et autres

Exploring the Role of Killer Cell Immunoglobulin-Like Receptors and Their HLA Class I Ligands in Autoimmune Hepatitis

Roberto Littera, Luchino Chessa, Simona Onali, Francesco Figorilli et autres

BACKGROUND: Natural killer cells are involved in the complex mechanisms underlying autoimmune diseases but few studies have investigated their role in autoimmune hepatitis. Killer immunoglobulin-like receptors are key regulators of natural killer cell-mediated immune responses. METHODS AND FINDINGS: KIR gene frequencies, KIR …

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Poster Session 1: Autoimmune Liver Disease

Simona Onali, Carlo Carcassi, L Secci, Sara Cappellini et autres

Background/aim: Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with limited understanding of etiopathogenesis.Recently, a genome-wide association study (GWAS) identified a single nucleotide polymorphism (SNP, rs2187668) in the HLA-DQA1 gene, which is strongly associated with AIH type-1.We evaluated the impact of …

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Transient elastography in patients with chronic autoimmune hepatitis: is a good tool in evaluation of hepatic fibrosis?

Simona Onali, Sara Cappellini, Giancarlo Serra, Teresa Zolfino et autres

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Oral bacterial load in autoimmune liver diseases: possible role or coincidence?

Germano Orrù, Simona Onali, C. Salustro, Sara Cappellini et autres

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FATTORI IMPLICATI NELLA STORIA NATURALE DELL'INFEZIONE DA VIRUS DELTA:IL RUOLO DEGLI INTERFERONI

Martina Loi, Perra Francesca, Cinzia Balestrieri, Conti Maria et autres