Cengiz Karakaya

The Impact of Obesity on the Metabolic Profile of Patients with Polycystic Ovary Syndrome

Seher Elif Koçoğlu, Mustafa Kavutçu, İsmail Güler, Nazlı Canpunar et autres

Objective: The aim of this study was to evaluate the effects of polycystic ovary syndrome (PCOS) and accompanying obesity on various metabolic and biochemical parameters, particularly body composition, insulin resistance (IR), lipid profile, and inflammatory markers.Methods: A total of 120 women aged …

Assessing the potential of nifedipine and resveratrol to enhance ovarian viability in conjunction with detorsion treatment: A rat ovarian torsion model study

Aydan Sezgin, Asiye Aslı Emniyet Sert, Gülnur Take Kaplanoğlu, Cengiz Karakaya et autres

Objective: Evaluating the therapeutic effect of detorsion, resveratrol, and nifedipine on ovarian viability assessed by biochemical, histopathological and immunohistochemical parameters and markers of oxidative stress. Materials and Methods: Twenty-four Sprague-Dawley rats were included in 4 groups, namely: sham operation, ischemia-reperfusion (I/R), I/R+10 …

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Impact of Serum GDF-15 and IL-6 on Immunotherapy Response in Cancer: A Prospective Study

Orhun Akdoğan, Seval Türkmen, Galip Can Uyar, Kadriye Bır Yucel et autres

Background: Immunotherapy has transformed cancer treatment; however, predicting treatment response remains challenging. Serum biomarkers can help identify patients who are most likely to benefit from immunotherapy. Objective: This study evaluates the relationship between serum growth differentiation factor 15 (GDF-15) and interleukin-6 (IL-6) …

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RESVERATROL ATTENUATES HIGH GLUCOSE-INDUCED CYTOTOXICITY AND INFLAMMATION IN MOUSE GC-1 SPERMATOGONIA CELLS

Cengiz Karakaya, Omer Faruk Kırlangıç, Elif Irem KAVUTCU

Experimental study of the effectiveness of warm ischemia and cold ischemia during testis-sparing surgery in rats

Emine Doğan, Ayşe Karaman, Meltem Özgüner, Cengiz Karakaya

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Apoptosis inducing effect of sodium butyrate and cisplatin alone or in combination on SH-SY5Y human neuroblastoma cells

Ecem Kaya‐Sezginer, Omer Faruk Kırlangıç, Cengiz Karakaya, Sema Ören et autres

This study investigated the apoptotic effects of a histone deacetylase (HDAC) inhibitor, sodium butyrate (NaBu) and cisplatin as monotherapy or in combination on SH-SY5Y human neuroblastoma cells. MTT and colony formation assays were performed to investigate the anti-proliferative effects of NaBu in …

Protective Effects of Hydrogen-Rich Saline on Experimental Intestinal Volvulus in Rats

Hayrunnisa Oral, Zafer Türkyılmaz, Ramazan Karabulut, Cem Kaya et autres

BACKGROUND: Intestinal volvulus can cause morbidity and mortality. Surgical reduction, on the other hand, could result in ischemia-reperfusion (I/R) injury. Hydrogen rich saline solution (HRSS neutralizes free radicals in the body. This study aimed to investigate the effects of HRSS in I/R …

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The Impact of Serum LH levels on the Day of hCG Trigger on IVF Outcomes in Patients Undergoing GnRH Antagonist Protocols

Erhan Demirdağ, İsmail Güler, Cengiz Karakaya, Esin Şahin et autres

Objective: To evaluate whether hCG day serum LH levels have an impact on IVF outcomes in patients undergoing GnRH antagonist protocols.

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Further delineation of familial polycystic ovary syndrome (PCOS) via whole‐exome sequencing: PCOS ‐related rare FBN3 and FN1 gene variants are identified

Cengiz Karakaya, Aylin Pelin Çil, Kaya Bilgüvar, Tunahan Çakır et autres

AIM: To identify pathogenic rare coding Mendelian/high-effect size variant(s) by whole-exome sequencing in familial polycystic ovary syndrome (PCOS) patients to elucidate PCOS-related pathways. METHODS: Twenty women and their affected available relatives diagnosed with PCOS according to Rotterdam criteria were recruited. Whole-exome sequencing …

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Aberrant H19 Expression Disrupts Ovarian Cyp17 and Testosterone Production and Is Associated with Polycystic Ovary Syndrome in Women

Zhaojuan Chen, Lan Liu, Xi Xia, Martina S. Burn et autres

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ABERRANT H19 EXPRESSION DISRUPTS OVARIAN Cyp17 AND TESTOSTERONE PRODUCTION AND IS ASSOCIATED WITH POLYCYSTIC OVARY SYNDROME

Zhaojuan Chen, Lan Liu, Xi Xia, Cengiz Karakaya et autres

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Investigation of oxidative stress status in cumulus cells in patıents with in vitro fertilization

Rabia Tural, Cengiz Karakaya, Mehmet Erdem, Zeynep Coşkun Aykol et autres

Background/aim: The negative impact of oxidative stress on oocytes obtained from in vitro fertilization (IVF) patients is a challenge for the optimization of live birth rates. In this study, it is aimed to investigate whether oxidant/antioxidant parameters have a predictive value in …

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