Akihito Okazaki

ASO Visual Abstract: TMPRSS4 Expression Predicts Survival and Benefit From Neoadjuvant Chemotherapy in Pancreatic Cancer

Kenta Baba, Takeshi Sudo, Atsushi Yamaguchi, Tatsunori Hashimoto et autres

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TMPRSS4 Expression Predicts Survival and Benefit from Neoadjuvant Chemotherapy in Pancreatic Cancer

Kenta Baba, Takeshi Sudo, Atsushi Yamaguchi, Tatsunori Hashimoto et autres

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Clinical Profile and Predictors of Repeated Relapse in Type 1 Autoimmune Pancreatitis: A Multicenter Observational Study

Sho Saeki, Yasutaka Ishii, Keiji Hanada, Tamito Sasaki et autres

BACKGROUND AND AIM: Type 1 autoimmune pancreatitis (AIP) is a form of pancreatitis that responds well to glucocorticoid therapy and often results in clinical and radiological remission. However, AIP frequently relapses during long-term follow-up. While initial relapse is well described, repeated relapses …

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Nationwide epidemiological survey of acute pancreatitis in Japan, 2021: the impact of the COVID-19 pandemic and revised clinical guidelines

Yuichi Tanaka, Atsushi Masamune, Ryotaro Matsumoto, Tetsuya Takikawa et autres

OBJECTIVES: This study aimed to clarify the current clinico-epidemiological characteristics of acute pancreatitis (AP) in Japan. METHODS: We conducted a two-stage nationwide survey of patients with AP treated at selected hospitals in 2021, during the COVID-19 pandemic. The first stage estimated the …

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Clinicopathological features of type 1 autoimmune pancreatitis without elevated serum IgG4 level

Yumiko Yamashita, Yasutaka Ishii, Keiji Hanada, Tamito Sasaki et autres

Elevated serum IgG4 is a key diagnostic marker for type 1 autoimmune pancreatitis (AIP), but some patients lack IgG4 elevation, complicating diagnosis. This study investigated the clinicopathological features of AIP without elevated serum IgG4 levels. A total of 323 patients diagnosed with …

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Nonsurgical Pneumoperitoneum: A Rare Thoracoabdominal Complication of Asthma Exacerbation

Kazuhiko Iwasaki, Saya Tsukida, Akihito Okazaki

Asthma-related nonsurgical pneumoperitoneum is extremely rare. This case highlights that even without abdominal symptoms, free air may result solely from asthma exacerbation, and conservative treatment without fasting can be sufficient after surgical causes are excluded.

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POS0329 RECENT GLUCOCORTICOID-SPARING STRATEGIES LEAD TO BETTER PROGNOSIS FOR ANCA-ASSOCIATED VASCULITIS: INSIGHTS FROM THE MULTICENTER REVEAL COHORT STUDY

Mayu Shiomi, R. Watanabe, Mochammad Hatta, Shogo Matsuda et autres

Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) continues to carry a poor prognosis, and its treatment has historically relied on glucocorticoids (GC) and cyclophosphamide, forcing patients to endure burdensome side effects, particularly infections. Recently, novel molecularly targeted therapies, including mepolizumab and avacopan, …

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POS0450 COMPARISON OF LONG-TERM EFFICACY AND SAFETY OF RITUXIMAB VERSUS INTRAVENOUS CYCLOPHOSPHAMIDE AS A REMISSION INDUCTION THERAPY IN PATIENTS WITH SEVERE ANCA-ASSOCIATED VASCULITIS IN THE JAPANESE MULTICENTER REVEAL COHORT STUDY: ANALYSES WITH INVERSE PROBABILITY OF TREATMENT WEIGHTING

Shinji Matsuda, Takuya Kotani, Akihito Okazaki, Y. Masuda et autres

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small-vessel vasculitis [1]. AAV patients with life-threatening organ lesions, including rapidly progressive glomerulonephritis and alveolar hemorrhage, have a poor prognosis. Systemic glucocorticoids in combination with intravenous cyclophosphamide (CY) or rituximab (RTX) are …

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Direct Tumour Seeding Following Medical Thoracoscopy in EGFR ‐Mutated Lung Adenocarcinoma: A Case Report

Kazuhiko Iwasaki, Akihito Okazaki, Yasuhiko Matsuda

This case demonstrates the risk of tumour seeding after medical thoracoscopy for EGFR-mutated lung adenocarcinoma. Clinicians should balance the diagnostic benefits against potential complications, closely monitor intervention sites, and consider early local control strategies such as radiation therapy to effectively manage procedure-related …

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A Preoperative Diagnosis of Intra-Ampullary Papillary-Tubular Neoplasm with High-Grade Intraepithelial Neoplasia Following Curative Resection

Masashi Inoue, Tomoyuki Abe, Takuya Hattori, Ryota Kawamura et autres

Intra-ampullary papillary-tubular neoplasm (IAPN) is a rare, preinvasive neoplasm primarily affecting the ampullary channel, with minimal involvement of the bile duct, pancreatic duct, or duodenal papilla.It is characterized by papillary and/or tubular growth, exhibiting variable cell lineages and dysplastic changes, resembling intraductal …

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POS1295 POOR PROGNOSTIC FACTOR FOR RELAPSE OF INTERSTITIAL LUNG DISEASE COMPLICATED WITH ANTI-AMINOACYL-TRNA SYNTHETASE ANTIBODIES AFTER COMBINATION THERAPY: LONG-TERM FOLLOW-UP OF A SINGLE CENTRE COHORT

Shuichi Matsuda, Takuya Kotani, K. Oe, Akihito Okazaki et autres

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POS0308 LONG-TERM EFFICACY OF MEPOLIZUMAB IN PATIENTS WITH EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS: A PROPENSITY SCORE MATCHING ANALYSIS IN THE MULTICENTER REVEAL COHORT STUDY

Mayu Shiomi, Ryu Watanabe, Shogo Matsuda, Takuya Kotani et autres

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