Corey S. Moran

Osteoprotegerin: a pathological role in human abdominal aortic aneurysm

Corey S. Moran

Rupture of Abdominal Aortic Aneurysm (AAA) is the end-stage, catastrophic failure of the aneurysmal aortic wall and is associated with a mortality rate of up to 95 percent. Presently, surgery is the only treatment option available but carries with it a mortality …

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Preclinical ALM (Adenosine, Lidocaine, Magnesium): Navigating Doubts

Erik Biroš, Eva Birosova, Corey S. Moran

au (code pays fourni par la source)

Inflammatory or Reparative? Tuning Macrophage Polarization Using Anodized Anisotropic Nanoporous Titanium Implant Surfaces

Ho‐Jin Moon, Karan Gulati, Tao Li, Corey S. Moran et autres

Modulating macrophage phenotype based on implant surface characteristics, including topography and chemistry, has been employed to enhance osseointegration and long-term functional outcomes for titanium (Ti)-based implants. An excessive and/or prolonged M1 macrophage response can lead to damaging immune-inflammatory reactions, negatively influencing the …

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Unveiling clinical applications of bacterial extracellular vesicles as natural nanomaterials in disease diagnosis and therapeutics

Chun Liu, Negar Yazdani, Corey S. Moran, Carlos Salomón et autres

Bacterial extracellular vesicles (BEVs) are naturally occurring bioactive membrane-bound nanoparticles released by both gram-negative and gram-positive bacterial species, exhibiting a multifaceted role in mediating host-microbe interactions across various physiological conditions. Increasing evidence supports BEVs as essential mediators of cell-to-cell communicaiton, influencing bacterial …

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Modeling inflammatory response using 3D bioprinting of polarized macrophages

Nimal Raveendran, Kanchan Vaswani, Pingping Han, Saraswat Basu et autres

The field of drug discovery has seen the rise of three-dimensional (3D) bioprinting as a promising tool for disease modeling. The focus to date has been on tissue engineering and cancer modeling, although the application of 3D-bioprinted models for the study of …

3D bioprinted small extracellular vesicles from periodontal cells enhance mesenchymal stromal cell function

Pingping Han, Nimal Raveendran, Chun Liu, Saraswat Basu et autres

Recent research indicates that combining 3D bioprinting and small extracellular vesicles (sEVs) offers a promising 'cell-free' regenerative medicine approach for various tissue engineering applications. Nonetheless, the majority of existing research has focused on bioprinting of sEVs sourced from cell lines. There remains …

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Effects of periodontal cells‐derived extracellular vesicles on mesenchymal stromal cell function

Pingping Han, Nigel R. Johnson, Abdalla Abdal‐hay, Corey S. Moran et autres

OBJECTIVE: To enrich and compare three extracellular vesicles-EV subtypes (apoptotic bodies, microvesicles and small EV) from three periodontal cells (periodontal ligament cells-PDLCs, alveolar bone-derived osteoblasts-OBs and gingival fibroblasts-GFs), and assess uptake and cell function changes in buccal fat pad-derived mesenchymal stromal cells …

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Nanosurface Texturing for Enhancing the Antibacterial Effect of Biodegradable Metal Zinc: Surface Modifications

Enmao Xiang, Corey S. Moran, Sašo Ivanovski, Abdalla Abdal‐hay

Zinc (Zn) as a biodegradable metal has attracted research interest for bone reconstruction, with the aim of eliminating the need for a second removal surgery and minimizing the implant-to-bone transfer of stress-shielding to maintain bone regeneration. In addition, Zn has been shown …

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TNF-α and OSX mRNA of Salivary Small Extracellular Vesicles in Periodontitis: A Pilot Study

Pingping Han, Kexin Jiao, Corey S. Moran, Andrew Liaw et autres

This cross-sectional pilot study explored extracellular vesicle (EV)-derived gene expression of markers for bone turnover and pro-inflammatory cytokines in periodontal disease. Whole unstimulated saliva was collected from 52 participants (18 healthy, 13 gingivitis, and 21 stages III/IV periodontitis), from which salivary small …

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Mechanistic considerations for adenosine-lidocaine-magnesium (ALM) in controlling coagulopathy

Erik Biroš, Eva Birosova, Corey S. Moran

au (code pays fourni par la source)

Nano Surface Texturing for Enhancing Antibacterial Effect of Biodegradable Metal Zinc: Surface Modifications

Enmao Xiang, Corey S. Moran, Sašo Ivanovski, Abdalla Abdal‐hay

au (code pays fourni par la source)

Antibody response to BNT162b2 mRNA vaccine in gingival crevicular fluid

Pingping Han, Corey S. Moran, Srinivas Sulugodu Ramachandra, Laurence J. Walsh et autres

BACKGROUND: This prospective cohort study aimed to evaluate the antibody responses in non-invasive gingival crevicular fluid (GCF) and unstimulated whole saliva to the SARS-CoV-2 Spike unit 1 receptor-binding domain (S1-RBD) protein following administration of the mRNA BNT162b2 vaccine. METHODS: This longitudinal study …

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