Profil bibliographique

Miranda M.C. van der Lee

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

2Publications signalées
37Citations signalées
0Affiliations récentes

Les domaines associés

Thyroid Disorders and TreatmentsNeuropeptides and Animal PhysiologyImmune Cell Function and InteractionImmune cells in cancerOphthalmology and Eye Disorders

Les publications récentes

2023 article OpenAlex

Thyrotropin Receptor Antagonism by a Novel Small Molecule: Preclinical In Vitro Observations

George J. Kahaly, Lisa A. Steiner, Miranda M.C. van der Lee, Tanja A.E. van Achterberg et autres

Background:Treatment of Graves' hyperthyroidism (GH) and Graves' orbitopathy (GO) is far from adequate, and hence, new substances that specifically target the autoantigens in GH/GO are warranted. This study determined the preclinical in vitro efficacy of SYD5115, a novel low-molecular-weight compound that inhibits …

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17 citations Thyroid
Accès ouvert 2023 article OpenAlex

BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells

Mary J. van Helden, Seline A. Zwarthoff, Roel J. Arends, Inge Reinieren-Beeren et autres

Background Preclinical studies have firmly established the CD47-signal-regulatory protein (SIRP)α axis as a myeloid immune checkpoint in cancer, and this is corroborated by available evidence from the first clinical studies with CD47 blockers. However, CD47 is ubiquitously expressed and mediates functional interactions …

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20 citations Journal for ImmunoTherapy of Cancer
Notice OpenAlex

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