Accès ouvert
2025
article
OpenAlex
Yujuan Velvin Fu, Xiaoxuan Yang, Sihui Li, Chenyang Ma et autres
CRISPR activation (CRISPRa) is a powerful tool for endogenous gene activation, yet the mechanisms underlying its optimal transcriptional activation remain unclear. By monitoring real-time transcriptional bursts, we find that CRISPRa modulates both burst duration and amplitude. Our quantitative imaging reveals that CRISPR-SunTag …
cn
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Accès ouvert
2023
article
OpenAlex
Chaoqun Li, Peng Teng, Shengbai Sun, Kaisa Cui et autres
Folate-mediated one-carbon metabolism (FOCM) is crucial in sustaining rapid proliferation and survival of cancer cells. The folate cycle depends on a series of key cellular enzymes, including aldehyde dehydrogenase 1 family member L2 (ALDH1L2) that is usually overexpressed in cancer cells, but …
cn, jp
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Accès ouvert
2023
article
OpenAlex
Min Li, Shengbai Sun, Zehua Bian, Surui Yao et autres
Long noncoding RNAs (lncRNAs) play an important role in tumor progression. Small nucleolar RNA host gene 15 (SNHG15) is a lncRNA that has been confirmed to play an oncogenic role in multiple cancer types. However, its role in glycolysis and chemoresistance in …
cn
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Accès ouvert
2022
article
OpenAlex
Xue Bing Wang, Han Cheng, Jing Zhao, Jiuming Li et autres
BACKGROUND: Long noncoding RNAs (lncRNAs) have driven research focused on their effects as oncogenes or tumor suppressors involved in carcinogenesis. However, the functions and mechanisms of most lncRNAs in colorectal cancer (CRC) remain unclear. METHODS: The expression of DLGAP1-AS2 was assessed by …
cn
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2022
article
OpenAlex
Kaisa Cui, Liang Gong, Han Zhang, Ying Chen et autres
cn, us
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Accès ouvert
2022
article
OpenAlex
Kaisa Cui, Surui Yao, Bingxin Liu, Shengbai Sun et autres
cn, us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Fan Yang, Zehua Bian, Peiwen Xu, Shengbai Sun et autres
MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA molecules with a length of approximately 18-25 nt nucleotides that regulate gene expression post-transcriptionally. MiR-204-5p originates from the sixth intron of the transient receptor potential cation channel subfamily M member 3 (TRPM3) gene. …
cn
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Accès ouvert
2022
preprint
OpenAlex
Xue Bing Wang, J. Y. Zhao, Han Cheng, Jiuming Li et autres
Abstract Background: Long noncoding RNAs (lncRNAs) have driven research focused on their effects as oncogenes or tumor suppressors involved in carcinogenesis. However, the functions and mechanisms of most lncRNAs in colorectal cancer (CRC) remain unclear. Methods: The expression of DLGAP1-AS2 was assessed …
cn, in
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Accès ouvert
2022
dataset
OpenAlex
Jia Zhang, Kaisa Cui, Liuying Huang, Fan Yang et autres
Additional file 8: Table S6. A total of 754 regulated DEGs (|logFC|≧0.5) selected after both overexpression and knockdown of SLCO4A1-AS1 in two independent RNA sequencing data sets.
cn
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Accès ouvert
2022
dataset
OpenAlex
Jia Zhang, Kaisa Cui, Liuying Huang, Fan Yang et autres
Additional file 5: Table S4. The related original data of Fig. 2d.
cn
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Accès ouvert
2022
dataset
OpenAlex
Jia Zhang, Kaisa Cui, Liuying Huang, Fan Yang et autres
Additional file 2: Table S2. List of primers.
cn
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Accès ouvert
2022
dataset
OpenAlex
Jia Zhang, Kaisa Cui, Liuying Huang, Fan Yang et autres
Additional file 3: Table S3. Identificantion of fourteen lncRNAs candidates upregulation from 5 and 50 pairs CRC and adjacent tissues
cn
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