Mayur K. Ladumor

Advancing Pharmacoequity Globally: Reflections from the ASCPT Development, Regulatory, and Outcomes Network

Priya Jayachandran, Mayur K. Ladumor, Georgios Vlasakakis, Andrew Riselli et autres

ASCPT has a mission to advance clinical pharmacology and translational sciences to reduce health disparities. The development, regulatory, and outcomes (DRO) network within ASCPT strives to advance pharmacoequity globally. Pharmacoequity, coined by Utibe Essien (2021), is the principle that all individuals, regardless …

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The JPET Editorial Fellowship: Opening the Blinds to the Peer Review and Editorial Process

Mayur K. Ladumor, Catharine A. Mielnik, Cristina D. Peterson, Freeborn Rwere et autres

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Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model

Flavia Storelli, Mayur K. Ladumor, Xiaomin Liang, Yurong Lai et autres

Abstract Hepatic impairment (HI) moderately (<5‐fold) affects the systemic exposure (i.e., area under the plasma concentration–time curve [AUC]) of drugs that are substrates of the hepatic sinusoidal organic anion transporting polypeptide (OATP) transporters and are excreted unchanged in the bile and/or urine. …

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A Physiologically-Based Pharmacokinetic Model for Cannabidiol in Healthy Adults, Hepatically-Impaired Adults, and Children

Sumit Bansal, Mayur K. Ladumor, Mary F. Paine, Jashvant D. Unadkat

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Predicting changes in the pharmacokinetics of CYP3A‐metabolized drugs in hepatic impairment and insights into factors driving these changes

Mayur K. Ladumor, Flavia Storelli, Xiaomin Liang, Yurong Lai et autres

Physiologically based pharmacokinetic models, populated with drug-metabolizing enzyme and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment (HI) on the pharmacokinetics (PK) of drugs. To increase confidence in the predictive power of such models, they must be …

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The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans

Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor et autres

This is the accepted manuscript version of the work published in its final form as Storelli, F., Yin, M., Kumar, A. R., Ladumor, M. K., Evers, R., Chothe, P. P., Enogieru, O. J., Liang, X., Lai, Y., & Unadkat, J. D. (2022). …

The next frontier in ADME science: Predicting transporter-based drug disposition, tissue concentrations and drug-drug interactions in humans

Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor et autres

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Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling

Ankit Balhara, Mayur K. Ladumor, Rakesh P. Nankar, Samiulla Dodheri Syed et autres

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Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model

Mayur K. Ladumor, Jashvant D. Unadkat

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Estimation of Fetal-to-Maternal Unbound Steady-State Plasma Concentration Ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein Substrate Drugs Using a Maternal-Fetal Physiologically Based Pharmacokinetic Model

Jinfu Peng, Mayur K. Ladumor, Jashvant D. Unadkat

Pregnant women are frequently prescribed drugs to treat chronic diseases such as human immunodeficiency virus infection, but little is known about the benefits and risks of these drugs to the fetus that are driven by fetal drug exposure. The latter can be …

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The Next Frontier in ADME Science: Predicting Transporter-Based Drug Disposition, Tissue Concentrations and Drug-Drug Interactions in Humans

Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor et autres

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A Tribute to Professor Saranjit Singh - A Critical Thinker, Innovator, Mentor, and Educator

Mayur K. Ladumor, Amrit Paudel, Dattatray T. Modhave, S.C. Sharma et autres

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