Sergey V. Baykov

Synthesis of 1,2,4-Oxadiazole Sulfonamide Derivatives and Their Biological Investigation as Monoamine Oxidase Inhibitors

Антон А. Шетнев, Olga A. Gasilina, Sergey V. Baykov, Рахымжан А. Турманов et autres

Monoamine oxidase (MAO) enzymes catalyze the catabolism of neurotransmitter amines, and MAO inhibitors are therefore of much clinical value. Based on the continued interest in MAO inhibitors, the present study examined the MAO inhibition properties of 1,2,4-oxadiazole sulfonamide derivatives. While we previously …

ru, kz, Afrique du Sud (code pays fourni par la source)

Crystal Structure of 1,1-Dimethyl-3-(quinolin-2-yl)urea and 3-(Isoquinolin-1-yl)-1,1-dimethylurea

Svetlana O. Baykova, Sergey V. Baykov, Vadim P. Boyarskiy, Nadezhda A. Bokach

The crystal structures of two isomeric urea derivatives—1,1-dimethyl-3-(quinolin-2-yl)urea (1) and 3-(isoquinolin-1-yl)-1,1-dimethylurea (2)—have been investigated by single-crystal X-ray diffraction. These compounds differ in the relative position of the heterocyclic nitrogen atom and the urea substituent. A structural study revealed that the compounds exhibit …

ru (code pays fourni par la source)

Coordination-Induced σ-Hole Chalcogen Bonding Involving Anionic Sulfur Donors of Dithiocarbamate-Type Ligands: Electrophilicity of Anions in Group 10 Metal Complexes

Eugene V. Ignatov, Лев Е. Зеленков, Sergey V. Baykov, Daniil M. Ivanov et autres

Abstract Coordination-induced electrophilic activation of anionic ligands inverts the conventional reactivity of coordination compounds. Here, we report experimental and theoretical evidence for σ-hole chalcogen bond (ChB) donation from anionic dithiocarbamate-type sulfur centers. Isomorphous Group 10 metal complexes bearing a fluorosulfonamide-modified dithiocarbamate ligand, …

ru, cn, us (code pays fourni par la source)

Columnar stacks versus metal-involved dimers: supramolecular behavior of square-planar Cu(II) complexes with deprotonated N-(Pyridin-2-yl)ureas

Sergey V. Baykov, Vladislava V. Matveevskaya, Alexander S. Novikov, Artem V. Semenov et autres

ru (code pays fourni par la source)

Dual Donor–Acceptor Behavior of Tellurium(II) in Cocrystals: Tuning Noncovalent Interactions with σ- and π-Hole Donors

Лев Е. Зеленков, Eugene V. Ignatov, Sergey V. Baykov, Daniil M. Ivanov et autres

Abstract The unique electronic structure of tellurium enables a dual donor–acceptor behavior in noncovalent interactions (NCIs) that can be systematically tuned. In this work, we investigate the cocrystallization of tellurium(II) bis(diethyldithiocarbamate) (1) with σ-hole (1,4-diiodo-2,3,5,6-tetrafluorobenzene and 1,3,5-triiodo-2,4,6-trifluorobenzene) and π-hole (1,2,4,5-tetracyanobenzene, TCB) donors. …

cn, ru, us (code pays fourni par la source)

Overcoming Kinetic Inertness via Transmetalation: Nickel-Mediated Synthesis of Sulfonamide-Functionalized Pd II and Pt II Dithiocarbamates

Eugene V. Ignatov, Лев Е. Зеленков, Sergey V. Baykov, Matvey K. Shurikov et autres

A transmetalation strategy has been developed to access sulfonamide-functionalized palladium(II) and platinum(II) dithiocarbamate complexes that are inaccessible through direct functionalization due to the kinetic inertness of these metals. While kinetically labile nickel(II) dithiocarbamates readily undergo sulfonamide insertion into Ni II –S bonds, …

ru, cn (code pays fourni par la source)

Recyclable Palladium-Polysiloxane Catalyst with Ultra-Low Metal Leaching for Drug Synthesis

Ekaterina A. Golovenko, Dmitrii Vasil'evich Pankin, Sergey V. Baykov, Vadim Yu. Kukushkin et autres

A carbon-supported palladium-containing polysiloxane macrocatalyst (Pd-PDMS) was developed for pharmaceutical-grade cross-coupling reactions. The catalyst demonstrates exceptional year-long stability at room temperature while maintaining full catalytic activity. Pd-PDMS efficiently promotes three pharmaceutically relevant reactions: Suzuki coupling (80% yield), copper-free Sonogashira coupling (90% yield …

ru (code pays fourni par la source)

Unraveling the Nature of Ch–S Interactions in Tellurium(II) and Selenium(II) Dithiocarbamates: A Benchmark Study for Distinguishing Coordination Bonds from Intramolecular Chalcogen Bonds

Eugene V. Ignatov, Лев Е. Зеленков, Sergey V. Baykov, Sergi Burguera et autres

This study presents the first systematic quantum chemical investigation establishing benchmark criteria for distinguishing coordination bonds from intramolecular chalcogen bonds in heavy chalcogen compounds. Through experimental and computational analysis of the tellurium(II) and selenium(II) dithiocarbamate complexes [Te(S 2 CNEt 2 ) 2 …

ru, cn, es (code pays fourni par la source)

Structural resilience in organic–inorganic stacked assemblies: sulfur-mediated self-compensating interaction and metal identity masking in group 10 dithiocarbamate cocrystals with tetracyanobenzene

Лев Е. Зеленков, Sergey V. Baykov, Maxim L. Kuznetsov, E. Kh. Sadykov et autres

The ligands’ environment masks electronic differences between Ni, Pd, and Pt via a sulfur-mediated self-compensating mechanism and results in identical supramolecular architectures for cocrystals of metal dithiocarbamates with tetracyanobenzene.

cn, ru, pt (code pays fourni par la source)

Aerobic Oxidation of Imidazolines to 2-Arylimidazoles Using CuSO4∙H2O as a Catalyst

Kristina A. Myachina, Artem V. Semenov, Matvey K. Shurikov, Sergey V. Baykov et autres

Abstract Imidazoles are considered the merit heterocyclic moiety in medicinal chemistry and drug design. Here, we report on a convenient method for the aerobic oxidation of imidazolines under mild conditions using the cheap and available CuSO4∙5H2O as the catalyst. The proposed method …

ru (code pays fourni par la source)

Expanding the antiviral arsenal: N-arylated 1,2,4-oxadiazol-5(4H)-ones show high activity against orthopoxviruses

Artem V. Semenov, Sergey V. Baykov, Natalia S. Soldatova, Kirill K. Geyl et autres

ru (code pays fourni par la source)

Cooperativity of chalcogen and halogen bonding in cocrystals of PdII and PtII acetylacetonates with perfluoroarene selanes: Impact of the arene iodination on supramolecular architecture

Dmitry M. Kryukov, Aleksandra A. Khrustaleva, Sergey V. Baykov, Rosa M. Gomila et autres

ru, es (code pays fourni par la source)