Accès ouvert
2022
article
OpenAlex
Junchul Shin, Svyatoslav Tkachenko, Malay Chaklader, Connor Pletz et autres
AIMS: Until recently, the pluripotency factor Octamer (ATGCAAAT)-binding transcriptional factor 4 (OCT4) was believed to be dispensable in adult somatic cells. However, our recent studies provided clear evidence that OCT4 has a critical atheroprotective role in smooth muscle cells. Here, we asked …
us, ru
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Jasmine Gajeton, Irene Krukovets, Santoshi Muppala, Dmitriy Verbovetskiy et autres
The tumor microenvironment contains the parenchyma, blood vessels, and infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs affect the developing tumor and drive cancer inflammation. We used mouse models of hyperglycemia and cancer and specimens from hyperglycemic breast cancer (BC) patients to …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Nataliya A. Berezneva, Olga Stenina‐Adognravi, Andrey K. Uglitskikh
The aim of this work is to determine the causes of chest pain in children with combined pathology and to develop an examination algorithm for chest pain. Materials and methods. Examined 20 children aged 7-18 years who consulted a pediatrician with pain …
ru
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Jasmine Gajeton, Irene Krukovets, Revanth S Yendamuri, Dmitriy Verbovetskiy et autres
Obesity is associated with inflammation and insulin resistance (IR), but the regulation of insulin sensitivity (IS) and connections between IS and inflammation remain unclear. We investigated the role of miR-467a-5p, a miRNA induced by hyperglycaemia, in regulating inflammation and blood glucose handling. …
us
(code pays fourni par la source)
2020
article
OpenAlex
Santoshi Muppala, Roy Xiao, Jasmine Gajeton, Irene Krukovets et autres
Inflammation drives the growth of tumors and is an important predictor of cancer aggressiveness. CD68, a marker of tumor-associated macrophages (TAM), is routinely used to aid in prognosis and treatment choices for breast cancer patients. We report that thrombospondin-4 (TSP-4) mediates breast …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Jasmine Gajeton, Irene Krukovets, Santoshi Muppala, Dmitriy Verbovetskiy et autres
Abstract Background: Tumor microenvironment contains the parenchyma, blood vessels, and infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs affect the developing tumor and drive cancer inflammation. Methods: We used mouse models of hyperglycemia and cancer and specimens from hyperglycemic breast cancer (BC) …
us
(code pays fourni par la source)
2020
article
OpenAlex
Santoshi Muppala, Mohammed Tanjimur Rahman, Irene Krukovets, Dmitriy Verbovetskiy et autres
Abstract Thrombospondin‐4 (TSP4) is a pro‐angiogenic protein that has been implicated in tissue remodeling and local vascular inflammation. TSP4 and, in particular, its SNP variant, P387 TSP4, have been associated with cardiovascular disease. Macrophages are central to initiation and resolution of inflammation …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Jasmine Gajeton, Irene Krukovets, Santoshi Muppala, Dmitriy Verbovetskiy et autres
ABSTRACT Tumor microenvironment contains the parenchyma, blood vessels, and infiltrating immune cells, including tumor-associated macrophages (TAMs). TAMs affect the developing tumor and drive cancer inflammation. Hyperglycemic patients have a higher risk of developing breast cancer (BC). We have identified a novel miRNA-dependent …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Olga Stenina‐Adognravi, Josephine Clare Adams
[No Abstract]
us, gb
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Olga Stenina‐Adognravi, Joanne E. Murphy-Ullrich
Each year, a series of Science Research Conferences (SRCs) are sponsored by The Federation of American Societies for Experimental Biology (FASEB), a non-profit federation of 29 research societies representing 130,000 scientists, that allows experimental biologists to meet in a relaxing, collegial atmosphere …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Mohammed Tanjimur Rahman, Santoshi Muppala, Jiahui Wu, Irene Krukovets et autres
Abstract Thrombospondin-4 (TSP-4) attracted renewed attention recently as a result of assignment of new functions to this matricellular protein in cardiovascular, muscular, and nervous systems. We have previously reported that TSP-4 promotes local vascular inflammation in a mouse atherosclerosis model. A common …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Santoshi Muppala, Roy Xiao, Jasmine Gajeton, Irene Krukovets et autres
Abstract Inflammation drives the growth of tumors and is an important predictor of cancer aggressiveness. CD68, a marker of tumor-associated macrophages (TAM), is routinely used as a marker to aid in prognosis and treatment choices for breast cancer. We report that thrombospondin-4 …
us
(code pays fourni par la source)