Zhihao Jia

CNIH4 regulates systemic metabolism and exercise adaptations in male mice primarily through the modulation of β-adrenergic receptor trafficking

Xu Liu, Zhihong Wang, Shuya Chen, Runqi Wang et autres

Exercise improves glucose and lipid metabolism by remodeling skeletal muscle and adipose tissue, processes that depend on beta-adrenergic receptor signaling. How receptor trafficking and activation are coordinated across tissues remains unclear. Here we show that Cornichon homolog 4 controls beta-adrenergic receptor localization …

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ACAT3 controls hepatic cholesterol metabolism and modulates systemic energy homeostasis of male mice

Zhimin Ma, Q Chen, J Y Zhang, Zhengyun Huang et autres

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Lycium barbarum glycopeptide alleviates diabetic retinopathy and hepatic lipid disorder via modulation of the LXR-α/ABC transporter axis

Yixin Wang, Yunqi Zhang, Xiaoyang Che, Xiaoyu Xu et autres

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Harnessing mitohormesis: A thiazole-based mitochondrial respiration inhibitor restores metabolic homeostasis in type 2 diabetes

Yang Zhang, Jie Guo, Jie Jin, Ci-An Cheng et autres

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A Dual-Target Microbial Therapeutic Strategy for Treating Metabolic Diseases: Complementary Mechanisms and Clinical Prospects of Lactiplantibacillus plantarum and Akkermansia muciniphila

Si Liu, Mao Wang, Xiaobo Sun, Zhihao Jia et autres

Metabolic diseases, including obesity, type 2 diabetes, and their related complications, have emerged as major global public health challenges. Increasing evidence indicates that gut microbiota dysbiosis contributes to disrupted metabolic homeostasis, chronic low-grade inflammation, and progression of metabolic disorders. Among candidate microbiome-based …

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Self-assembled mesoporous bioglass polyphenol nanozymes for repairing musculoskeletal trauma

Shuao Zhao, Yesheng Jin, Zhihao Jia, Rongzhao Gu et autres

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Microbiota-driven tryptophan metabolic reprogramming mediates the lipid-modulating effects of red beetroot (Beta vulgaris L.)

Qingyang Wu, Tianren Shi, Zheng Pang, Xinwei Ge et autres

Ketogenic diet disrupts BDH1-mediated ketone metabolism and causes myocardial dysfunction in mice

Yin Li, Bin Guo, Hui Shu, Hongyu Fu et autres

Ketogenic diet (KD), recognized for its multiple metabolic benefits, such as enhanced glycemic homeostasis and weight loss, also imposes intricate influences on cardiac substrate utilization. While KD is effective in reducing blood glucose levels and improving insulin sensitivity, its long-term effects on …

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Myostatin Exhibits an Evolutionarily Conserved Circadian Pattern in Skeletal Muscles

Xiangpeng Liu, Changyou Song, Yan Xiong, Jinxin Gu et autres

ABSTRACT Introduction Myostatin (MSTN), a transforming growth factor‐beta (TGF‐β) superfamily member, is an evolutionarily conserved negative regulator of skeletal muscle mass. Loss of MSTN commonly promotes augmentation in skeletal muscle mass in all animal species examined. Recent studies have demonstrated that circadian …

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Multiomics analyses reveal that PRMT5 regulates membrane transport and cholesterol synthesis in white adipocytes

Xiyue Chen, Zhihao Jia, Xiashiyao Zhang, Feng Yue et autres

Abstract The adipose tissue (AT) is a main regulator of systemic energy homeostasis, and AT dysfunction leads to insulin resistance and other metabolic complications. Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetrical dimethylation of arginine residues to modulate protein stability and function. Besides …

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Metformin Administration Protects Against Deltoid Tendon Damage Through Activation of Notch Signaling

Can Liu, Runqi Wang, Yong Xu, Qingyi Liu et autres

Type 2 Diabetes Mellitus (T2DM) is a growing global health concern that is associated with severe complications including diabetic tendinopathy. In this study, we found that T2DM patients had a significantly higher prevalence of tendon surgery compared to non-T2DM patients, which were …

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CNIH4 regulates metabolic adaptations to exercise through β-adrenergic receptor-mediated ECM remodeling

Zhihao Jia, Xu Liu, Zhihong Wang, Tao Bo et autres

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