Emily V. Dutrow

Author Correction: CpG island turnover events predict evolutionary changes in enhancer activity

Acadia A. Kocher, Emily V. Dutrow, Severin Uebbing, Kristina Yim et autres

us, nl (code pays fourni par la source)

Erratum: Author Correction: CpG island turnover events predict evolutionary changes in enhancer activity (Genome biology (2024) 25 1 DOI: 10.1186/s13059-024-03300-z.)

Acadia A. Kocher, Emily V. Dutrow, Severin Uebbing, Kristina Yim et autres

Following publication of the original article [1], the authors reported an error in the description of the confidence interval shown by box-and-whisker plots in Figs. 1C, 1D, 2C, 2D, and 3E. Previously the legends for these figure panels incorrectly reported that whiskers …

Genomic reconstruction reveals impact of population management strategies on modern Galápagos dogs

Gabriella J. Spatola, Tatiana R. Feuerborn, Jennifer A. Betz, Reuben M. Buckley et autres

Free-breeding dogs have occupied the Galápagos Islands at least since the 1830s; however, it was not until the 1900s that dog populations grew substantially, endangering wildlife and spreading disease. 1 , 2 , 3 , 4 In 1981, efforts to control the …

us, be, ec, gb (code pays fourni par la source)

CpG island turnover events predict evolutionary changes in enhancer activity

Acadia A. Kocher, Emily V. Dutrow, Severin Uebbing, Kristina Yim et autres

BACKGROUND: Genetic changes that modify the function of transcriptional enhancers have been linked to the evolution of biological diversity across species. Multiple studies have focused on the role of nucleotide substitutions, transposition, and insertions and deletions in altering enhancer function. CpG islands …

us, nl (code pays fourni par la source)

CpG island turnover events predict evolutionary changes in enhancer activity

Acadia A. Kocher, Emily V. Dutrow, Severin Uebbing, Kristina Yim et autres

Genetic changes that modify the function of transcriptional enhancers have been linked to the evolution of biological diversity across species. Multiple studies have focused on the role of nucleotide substitutions, transposition, and insertions and deletions in altering enhancer function. Here we show …

us (code pays fourni par la source)

The dogs of Chernobyl: Demographic insights into populations inhabiting the nuclear exclusion zone

Gabriella J. Spatola, Reuben M. Buckley, Megan N. Dillon, Emily V. Dutrow et autres

The 1986 Chernobyl nuclear disaster initiated a series of catastrophic events resulting in long-term and widespread environmental contamination. We characterize the genetic structure of 302 dogs representing three free-roaming dog populations living within the power plant itself, as well as those 15 …

us, pl, ua, cn (code pays fourni par la source)

Domestic dog lineages reveal genetic drivers of behavioral diversification

Emily V. Dutrow, James A. Serpell, Elaine A. Ostrander

us (code pays fourni par la source)

Domestic dog lineages reveal genetic drivers of behavioral diversification

Emily V. Dutrow, James A. Serpell, Elaine A. Ostrander

Summary Selective breeding of domestic dogs has generated diverse breeds often optimized for performing specialized tasks. Despite the heritability of breed-typical behavioral traits, identification of causal loci has proven challenging due to the complexity of canine population structure. We overcome longstanding difficulties …

us (code pays fourni par la source)

Modeling uniquely human gene regulatory function in humanized mice

Emily V. Dutrow, Deena Emera, Kristina Yim, Severin Uebbing et autres

Abstract The evolution of uniquely human traits likely entailed changes in developmental gene regulation. Human Accelerated Regions (HARs), which include transcriptional enhancers harboring a significant excess of human-specific sequence changes, are leading candidates for driving gene regulatory modifications in human development. However, …

us (code pays fourni par la source)

Disrupting the three-dimensional regulatory topology of the Pitx1 locus results in overtly normal development

Richard Sarro, Acadia A. Kocher, Deena Emera, Severin Uebbing et autres

ABSTRACT Developmental gene expression patterns are orchestrated by thousands of distant-acting transcriptional enhancers. However, identifying enhancers essential for the expression of their target genes has proven challenging. Maps of long-range regulatory interactions may provide the means to identify enhancers crucial for developmental …

us (code pays fourni par la source)

Disrupting Pitx1 regulatory topology results in overtly normal limb development

Richard Sarro, Deena Emera, Severin Uebbing, Emily V. Dutrow et autres

Abstract Gene expression patterns during development are orchestrated in part by thousands of distant-acting transcriptional enhancers. However, identifying enhancers that are essential for expression of their target genes has proven challenging. Genetic perturbation of individual enhancers in some cases results in profound …

us (code pays fourni par la source)

Bestrophinopathy: An RPE-photoreceptor interface disease

Karina E Guziewicz, Divya Sinha, Néstor Más Gómez, Kathryn Zorych et autres

us (code pays fourni par la source)