Alexey Martyushev

Modeling Neurons in 3D at the Nanoscale

Wei‐Liang Chen, Iain Hepburn, Alexey Martyushev, Erik De Schutter

jp (code pays fourni par la source)

Modelling Ebola virus dynamics: Implications for therapy

Alexey Martyushev, Shinji Nakaoka, Kei Sato, Takeshi Noda et autres

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Epitope-Specific CD8+ T Cell Kinetics Rather than Viral Variability Determine the Timing of Immune Escape in Simian Immunodeficiency Virus Infection

Alexey Martyushev, Janka Petravic, Andrew J. Grimm, Hamid Alinejad‐Rokny et autres

CD8(+) T cells are important for the control of chronic HIV infection. However, the virus rapidly acquires "escape mutations" that reduce CD8(+) T cell recognition and viral control. The timing of when immune escape occurs at a given epitope varies widely among …

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Modeling the Timing of Antilatency Drug Administration during HIV Treatment

Janka Petravic, Alexey Martyushev, Jeanette C. Reece, Stephen John Kent et autres

UNLABELLED: Latently infected cells are considered a major barrier to the cure of HIV infection, since they are long-lived under antiretroviral therapy (ART) and cause viral replication to restart soon after stopping ART. In the last decade, different types of antilatency drugs …

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Measuring Turnover of SIV DNA in Resting CD4+ T Cells Using Pyrosequencing: Implications for the Timing of HIV Eradication Therapies

Jeanette C. Reece, Alexey Martyushev, Janka Petravic, Andrew J. Grimm et autres

Resting CD4+ T cells are a reservoir of latent HIV-1. Understanding the turnover of HIV DNA in these cells has implications for the development of eradication strategies. Most studies of viral latency focus on viral persistence under antiretroviral therapy (ART). We studied …

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Administration during HIV Treatment Modeling the Timing of Antilatency Drug

Stephen John Kent, Miles P. Davenport, Janka Petravic, Alexey Martyushev et autres

The search for an HIV cure: tackling latent infection

Stephen John Kent, Jeanette C. Reece, Janka Petravic, Alexey Martyushev et autres

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Trivalent Live Attenuated Influenza-Simian Immunodeficiency Virus Vaccines: Efficacy and Evolution of Cytotoxic T Lymphocyte Escape in Macaques

Jeanette C. Reece, Sheilajen Alcântara, Shayarana L. Gooneratne, Sinthujan Jegaskanda et autres

There is an urgent need for a human immunodeficiency virus (HIV) vaccine that induces robust mucosal immunity. CD8(+) cytotoxic T lymphocytes (CTLs) apply substantial antiviral pressure, but CTLs to individual epitopes select for immune escape variants in both HIV in humans and …

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