Ben Shelley

Epigenetics, inflammation and postoperative complications: a scoping review

Ruairí Wilson, Charlotte Fern, Kieran Woolcock, Carl Goodyear et autres

BACKGROUND: Excessive postoperative inflammation is associated with multisystem complications after surgery, culminating in morbidity, mortality and increased healthcare costs. Epigenetic modifications regulate gene transcription without altering DNA sequences and can augment powerful inflammatory responses. Translational studies have emerged, investigating how epigenetic mechanisms …

gb (code pays fourni par la source)

High-Flow Nasal Oxygen Therapy After Cardiac Surgery

Edward Litton, Rachael Parke, Shay McGuinness, Sarah Dawson et autres

Importance: High-flow nasal oxygen therapy (HFNOT) is used for noninvasive respiratory support following cardiac surgery despite uncertainty about its clinical effectiveness or associated costs. Objective: To determine whether prophylactic HFNOT in patients at increased risk of respiratory complications following cardiac surgery has …

au, nz, gb, ca, us (code pays fourni par la source)

Monitoring in Thoracic Anesthesia: EACTAIC Consensus Document

Mohamed R. El Tahan, Edda Tschernko, Jo Mourisse, Mert Şentürk et autres

sa, at, hu, nl, tr, gb, be (code pays fourni par la source)

Epigenetic regulation of inflammation in post-operative organ dysfunction: A scoping review protocol

Ruairí Wilson, Charlotte Fern, Carl S. Goodyear, Ben Shelley

INTRODUCTION: The inflammatory response to surgery is complex, dynamic and exhibits variability in magnitude and duration among patients undergoing similar operations. Dysregulated inflammation is associated with post-operative complications such as organ dysfunction, particularly after major surgery. Epigenetic modifications enhance (or suppress) selective …

gb (code pays fourni par la source)

Regional anaesthetic block for lung resection surgery: the magic bullet we already use?

Cara Hughes, Ben Shelley

nz, gb (code pays fourni par la source)

Cost-Utility Analysis of Accelerated and Standard Strategies for Renal Replacement Therapy Initiation

Jeff Round, İlke Akpinar, Charles Yan, Natasha Patel et autres

Importance: Little is known about the long-term costs and outcomes related to strategies for timing of initiation of kidney replacement therapy (KRT) in critically ill patients with severe acute kidney injury (AKI). Objective: To estimate the cost-utility and cost-effectiveness of accelerated KRT …

ca, il, us (code pays fourni par la source)

Postoperative Pulmonary Complications in Conventional Laparoscopic vs Robot-Assisted Abdominal Surgery

Simon Corrado Serafini, Sabrine N.T. Hemmes, Verônica N. F. Queiroz, Ary Serpa Neto et autres

Importance: Robot-assisted surgery (RAS) is increasingly used for abdominal procedures; however, postoperative pulmonary complications (PPCs) are more frequent in patients undergoing RAS compared with patients undergoing conventional laparoscopic surgery (CLS). Objective: To compare the incidence of PPCs after CLS and RAS and …

nl, at, it, us, br, au, es (code pays fourni par la source)

The cost-effectiveness of thoracic epidural versus paravertebral blockade in reducing chronic post-thoracotomy pain – a trial-based economic evaluation

Louise Jackson, Lee Middleton, Ben Shelley, H. Summers et autres

Abstract Thoracotomy surgery is associated with high levels of acute pain and can lead to chronic post-surgical pain. Two methods of regional analgesia are commonly used in patients undergoing thoracotomy surgery, thoracic epidural blockade (TEB) and paravertebral blockade (PVB). The economic evaluation …

gb, us (code pays fourni par la source)

Thoracic epidural versus paravertebral blockade for reducing chronic post-thoracotomy pain (TOPIC-2): an open-label, allocation-concealed, multicentre, randomised controlled trial

Ben Shelley, Lee Middleton, Rebecca Boyles, Michael Gilbert et autres

Structured Abstract Importance Many patients undergoing thoracotomy suffer from debilitating chronic post-thoracotomy pain (CPTP) lasting months or years postoperatively. The effectiveness of the commonly used two analgesic techniques, paravertebral blockade (PVB) and thoracic epidural blockade (TEB), on the incidence of CPTP is …

gb, us (code pays fourni par la source)

The clinical and cost-effectiveness of paravertebral blockade versus thoracic epidural blockade in reducing chronic post-thoracotomy pain: TOPIC2 RCT synopsis

Ben Shelley, Lee Middleton, Andreas Göebel, Stephen Grant et autres

Background: More than a third of patients undergoing thoracotomy suffer from debilitating chronic post-thoracotomy pain lasting months or years postoperatively. Aggressive management of acute pain during the perioperative period may mitigate this risk. Objective(s): To determine the clinical and cost-effectiveness of paravertebral …

gb, us (code pays fourni par la source)

Cardiovascular function changes following lung resection: a computational model to compare afterload increase and contractility loss mechanisms

S.M. Huang, Sanjay Pant, Sean McGinty, Richard Good et autres

Functional limitation after lung resection surgery has been consistently documented in clinical studies, and right ventricle (RV) dysfunction has been hypothesized as a contributing reason. However, the mechanisms of RV dysfunction after lung resection remain unclear, particularly whether change in afterload or …

Epigenetic regulation of inflammation in post-operative organ dysfunction: a scoping review protocol

Ruairí Wilson, Charlotte Fern, Carl S. Goodyear, Ben Shelley

Abstract Introduction The inflammatory response to surgery is complex, dynamic and exhibits variability in magnitude and duration among patients undergoing similar operations. Dysregulated inflammation is associated with post-operative organ dysfunction, particularly after major surgery. Epigenetic modifications enable (or prohibit) selective gene transcription …

gb (code pays fourni par la source)