Zaid Siddiqui

130. Development and validation of a U-Net-based deep learning model for intact and fractured metastatic vertebral body auto-segmentation on radiation planning CTs

Alex Flores, Thomas Hamre, Juan Zuluaga-Garcia, Sumeeth Jonathan et autres

104 Molecular Subgroups of IDH Wild-Type Glioblastoma Exhibit Distinct Treatment Responses to Resection and Adjuvant Therapy, a Multi-Institutional Study

Zachary C. Gersey, Arka N. Mallela, Jacob Young, Daniel Quintana et autres

INTRODUCTION: IDH wild-type glioblastoma (GBM) remains a clinically heterogeneous disease with poor survival outcomes. Prior molecular subclassification schemes lack clinical utility. Here, we use semi-supervised consensus clustering to identify molecular subtypes with distinct prognoses and treatment responses. METHODS: Eight hundred and fifty-eight …

Preoperative stereotactic radiosurgery for cerebral metastases: safe, effective, and decreases steroid dependency

Arka N. Mallela, Uzoma K. Iheagwara, David Fogg, Austin Anthony et autres

OBJECTIVE: Preoperative stereotactic radiosurgery (SRS) is emerging as a viable alternative to standard postoperative SRS. Studies have suggested that preoperative SRS provides comparable tumor control and overall survival (OS) and may reduce the incidence of leptomeningeal disease (LMD) and adverse radiation effects …

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RADT-09. PREOPERATIVE STEREOTACTIC RADIOSURGERY FOR LARGE CEREBRAL METASTASES – A PROSPECTIVE CLINICAL TRIAL SHOWING EFFICACY AND DECREASED TIME TO RESUMPTION OF IMMUNOTHERAPY

Arka N. Mallela, Uzoma K. Iheagwara, David Fogg, Austin Anthony et autres

Abstract INTRODUCTION Preoperative stereotactic radiosurgery (SRS) is an emerging therapeutic strategy for treatment of brain metastasis requiring surgical resection. Prior reports have been highly-controlled, excluding very large brain metastases. Here, we report a prospectively-collected preoperative series reflective of a real-world neurosurgical patient …

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SURG-42. MOLECULAR PROFILE CONSENSUS CLUSTERING DEFINES CLINICALLY DISTINCT GROUPS IN IDH WILD-TYPE GLIOBLASTOMA

Zachary C. Gersey, Arka N. Mallela, Xiaoran Zhang, Matthew Pease et autres

Abstract OBJECTIVES Although the impact of surgery in glioblastoma (GBM) is well-established, there is insufficient data to determine how surgical resection affects overall survival (OS). The impact of other GBM genomic alterations on EOR-induced survival remains poorly understood. Here, we leverage a …

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Abstract A013: Integrating imaging and sequencing to compute the subcellular organization of a cell’s transcriptome

Andrew Schultz, Saeed Alahmari, Pallavi Singh, Zaid Siddiqui et autres

Abstract Background: Incorporation of prior information in the form of pathway activity profiles was key in the success of the algorithm that won the DREAM challenge to predict in vitro cell fitness from transcriptomic and other multi-omic datasets (Costello, C. C et …

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