Christina L. Hayes

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

Bruno Lamas, Leticia Hernández-Galán, Heather J. Galipeau, Marco Constante et autres

, or pharmacological stimulation using 6-formylindolo (3,2-b) carbazole (Ficz) decreased immunopathology in NOD/DQ8 mice exposed to gluten. We then determined AhR ligand production by the fecal microbiota and AhR activation in patients with active celiac disease compared to nonceliac control individuals. Patients …

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Microbes and mental health: Can the microbiome help explain clinical heterogeneity in psychiatry?

Christina L. Hayes, Brett J. Peters, Jane A. Foster

Trillions of microbes cover the surfaces of our bodies and inhabit our gastrointestinal tract. In the past decade, research efforts examining the role of the microbiome in mental health have moved to the forefront of neuroscience and psychiatry. Based on a foundation …

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1123 ARYL HYDROCARBON RECEPTOR LIGAND PRODUCTION BY THE GUT MICROBIOTA IN CELIAC DISEASE

Heather J. Galipeau, Bruno Lamas, Leticia Hernández-Galán, Marco Constante et autres

Commensal microbiota induces colonic barrier structure and functions that contribute to homeostasis

Christina L. Hayes, Jasmine Dong, Heather J. Galipeau, Jennifer Jury et autres

The intestinal barrier encompasses structural, permeability and immune aspects of the gut mucosa that, when disrupted, may contribute to chronic inflammation. Although gnotobiotic studies have demonstrated the effects of microbiota on mucosal and systemic immunity, as well as intestinal barrier architecture and …

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IMPACT OF GUT MICROBIOTA ON INTESTINAL BARRIER FUNCTION AND INTEGRITY

Christina L. Hayes

Su1891 Colonization of Germ-Free Mice With Human Derived Microbiota Induces Progressive Ultrastructural, Innate, and Functional Changes in the Intestinal Barrier

Christina L. Hayes, Jennifer Jury, Jasmine Dong, Avee Naidoo et autres

Importance of the Microbiota in Early Life and Influence on Future Health

Elena F. Verdú, Christina L. Hayes, Siobhain M. O’Mahony

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Tu1829 Discovery of an Epithelial Form of Elastase in the Intestine That Participates to Mucosal Inflammation in IBD

Céline Deraison, Ana Carolina Florence, Alexandre Denadai‐Souza, Anissa Edir et autres

Efficacy of Bifidobacterium breve NCC2950 against DSS-induced colitis is dependent on bacterial preparation and timing of administration

Christina L. Hayes, Jane M. Natividad, Jennifer Jury, Rebeca Martín et autres

Probiotics have been proposed as a therapy for inflammatory bowel disease, but variations in strains, formulations, and protocols used in clinical trials have hindered the creation of guidelines for their use. Thus, preclinical insight into the mechanisms of specific probiotic strains and …

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Differential Induction of Antimicrobial REGIII by the Intestinal Microbiota and Bifidobacterium breve NCC2950

Jane M. Natividad, Christina L. Hayes, Jean‐Paul Motta, Jennifer Jury et autres

The intestinal microbiota is a key determinant of gut homeostasis, which is achieved, in part, through regulation of antimicrobial peptide secretion. The aim of this study was to determine the efficiency by which members of the intestinal microbiota induce the antimicrobial peptide …

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Tu1980 Optimization of the Use of Probiotics to Prevent and Treat Colitis

Christina L. Hayes, Jennifer Jury, Jane M. Natividad, Jun Lü et autres