Yuechen Zhou

FOSL2 regulates endothelial cell state and chromatin accessibility in systemic sclerosis pulmonary vascular remodeling

Rithika Behera, Yuechen Zhou, Peter H. Gerges, Jingyu Fan et autres

Systemic sclerosis (SSc) is characterized by fibrosis and vasculopathy affecting the skin and internal organs, leading to multiorgan dysfunction. Injury of microvascular endothelial cells (ECs) in SSc impairs blood flow and causes tissue ischemia, leading to vascular complications such as Raynaud's, digital …

FOSL2 regulates endothelial cell state and chromatin accessibility in systemic sclerosis pulmonary vascular remodeling

Rithika Behera, Yuechen Zhou, Peter H. Gerges, Jingyu Fan et autres

Systemic sclerosis (SSc) is characterized by fibrosis and vasculopathy affecting the skin and internal organs, leading to multiorgan dysfunction. Injury of microvascular endothelial cells (ECs) in SSc impairs blood flow and causes tissue ischemia, leading to vascular complications such as Raynaud's, digital …

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Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis

Urvashi Kaundal, Pei-Suen Tsou, Mousumi Sahu, Mengqi Huang et autres

OBJECTIVES: Vasculopathy and fibrosis are central to the pathogenesis of systemic sclerosis (SSc) and their genetic underpinnings are largely unknown. Here, we sought to examine the aetiology of severe vascular phenotypes and poorer outcomes in African American (AA) patients with SSc. METHODS: …

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Altered AP-1, RUNX, and EGR chromatin dynamics drive human fibrotic lung disease

Eleanor Valenzi, Minxue Jia, Peter Gerges, Jingyu Fan et autres

Objectives Pulmonary fibrosis can result from autoimmune, inflammatory, or idiopathic conditions, including systemic sclerosis-associated interstitial lung disease (SSc-ILD). Previous studies have implicated myofibroblasts and SPP1 hi macrophages as drivers of fibrosis in lungs, as well as other tissues. Single-cell RNA-sequencing has delineated …

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Altered AP-1, RUNX and EGR chromatin dynamics drive fibrotic lung disease

Eleanor Valenzi, Minxue Jia, Peter Gerges, Jing‐Yu Fan et autres

macrophages as drivers of fibrosis. Single-cell RNA sequencing has delineated fibroblast and macrophages transcriptomes, but limited insight into transcriptional control of profibrotic gene programs. To address this challenge, we analyzed multiomic snATAC/snRNA-seq on explanted SSc-ILD and donor control lungs. The neural network …

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Molecular Changes Implicate Angiogenesis and Arterial Remodeling in Systemic Sclerosis–Associated and Idiopathic Pulmonary Hypertension

Yuechen Zhou, Tracy Tabib, Mengqi Huang, Ke Yuan et autres

BACKGROUND: Pulmonary hypertension (PH) is a common complication of systemic sclerosis (SSc) and a leading cause of mortality among patients with this disease. PH can also occur as an idiopathic condition (idiopathic pulmonary arterial hypertension). Investigation of transcriptomic alterations in vascular populations …

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Abstract 1099: Single-cell Transcriptomic And Epigenic Profiling Identifies Sox6 As A Key Regulator Of Arterial Endothelial Cell Phenotype In Systemic Sclerosis-associated Pulmonary Hypertension

Yuechen Zhou, Tracy Tabib, Mengqi Huang, John Sembrat et autres

Background: Pulmonary hypertension (PH) frequently arises as a complication of systemic sclerosis (SSc), and is a major cause of death among patients with this condition. Pulmonary vasculopathy in SSc is characterized by endothelial dysfunction with subsequent remodeling of the pulmonary vasculature, especially …

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Upregulation of IFNE in cervical biopsies of patients with high‐risk human papillomavirus infections

Lu Zhang, Yuechen Zhou, Xiaoyan Xing, Hua Li et autres

PROBLEM: Interferon epsilon (IFN-ε) is constitutively expressed in the epithelium of female reproductive tract and confers vital protection against sexually transmitted pathogens in mouse models. However, there is limited insight into the role of IFN-ε in human sexually transmitted infections such as …

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Compatible paraffin@SiO2 microcapsules/polydimethylsiloxane composites with heat storage capacity and enhanced thermal conductivity for thermal management

Yuechen Zhou, Shushan Li, Yuliang Zhao, Ziye Ling et autres

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