Paulina D. Ramírez-García

MMP1 and PRSS23 induce PAR2 biased agonism in painful oral cancers

Paulina D. Ramírez-García, Igor Dolgalev, Zinaida Dubeykovskaya, Rocco Latorre et autres

Protease-activated receptor 2 (PAR2) mediates oral cancer pain. Patients with metastatic (N + ) cancers report greater pain. PAR2 is activated by N-terminal proteolytic cleavage. Here we show that proteases encoded by genes overexpressed in N+ cancers from patients with pain (matrix …

us (code pays fourni par la source)

Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission

Jeffri S. Retamal, Shane D. Hellyer, Paulina D. Ramírez-García, Rocco Latorre et autres

Abstract Metabotropic glutamate receptor 5 (mGlu 5 ) is a class C GPCR crucial for neuronal development and synaptic transmission. mGlu 5 is a potential therapeutic target in pain management and modulates pain-associated gene expression and signaling pathways. Although mGlu 5 inhibitors …

cl, au, us (code pays fourni par la source)

Targeting endosomal receptors, a new direction for polymers in nanomedicine

Paulina D. Ramírez-García, Nicholas A. Veldhuis, Nigel W. Bunnett, Thomas P. Davis

In this perspective, we outline a new opportunity for exploiting nanoparticle delivery of antagonists to target G-protein coupled receptors localized in intracellular compartments. We discuss the specific example of antagonizing endosomal receptors involved in pain to develop long-lasting analgesics but also outline …

us, au (code pays fourni par la source)

Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity

Carlos Morgan, Patricio Sáez‐Briones, Rafael Barra, Katherine Zepeda-Morales et autres

A loss of neuroplastic control on nucleus accumbens (NAc) neuronal activity exerted by the medial prefrontal cortex (mPFC) through long-term depression (LTD) is involved in triggering drug-seeking behavior and relapse on several substances of abuse due to impaired glutamate homeostasis in tripartite …

cl, us (code pays fourni par la source)

Oral Cancer Cells Release Vesicles that Cause Pain

Zinaida A. Dubeykovskaya, Nguyen Huu Tu, Paulina D. Ramírez-García, Brian L. Schmidt et autres

Oral cancer pain is attributed to the release from cancers of mediators that sensitize and activate sensory neurons. Intraplantar injection of conditioned media (CM) from human tongue cancer cell line HSC-3 or OSC-20 evokes nociceptive behavior. By contrast, CM from noncancer cell …

us (code pays fourni par la source)

Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain

Rocco Latorre, Paulina D. Ramírez-García, Alan Hégron, James L. Grace et autres

us, au (code pays fourni par la source)

Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

Francesco De Logu, Romina Nassini, Alan Hégron, Lorenzo Landini et autres

Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the site and mechanism of CGRP-evoked peripheral pain remain unclear. By cell-selective RAMP1 gene deletion, we …

it, us, au (code pays fourni par la source)

CGRP Signals from Endosomes of Schwann Cells to Elicit Migraine Pain

Francesco De Logu, Romina Nassini, Alan Hégron, Lorenzo Landini et autres

Abstract Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the site and mechanism of CGRP-evoked migraine pain remain unknown. By cell-selective RAMP1 gene deletion, …

it, us, au (code pays fourni par la source)

Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice

Jeffri S. Retamal, Megan S. Grace, Larissa K. Dill, Paulina D. Ramírez-García et autres

au, us (code pays fourni par la source)

Polymeric micelles with anti-virulence activity against Candida albicans in a single- and dual-species biofilm

Yassamin N. Albayaty, Nicky Thomas, Paulina D. Ramírez-García, Thomas P. Davis et autres

au, us (code pays fourni par la source)

pH-Responsive copolymer micelles to enhance itraconazole efficacy against Candida albicans biofilms

Yassamin N. Albayaty, Nicky Thomas, Paulina D. Ramírez-García, Thomas P. Davis et autres

Candida albicans (C. albicans) is a common fungal pathogen causing both localised and systemic infections. The majority of these infections are promoted by biofilm formation, providing a protective matrix for the embedded fungi thereby evading the host immune defence and promoting resistance …

au, us (code pays fourni par la source)

Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain

Jeffri S. Retamal, Paulina D. Ramírez-García, Priyank A. Shenoy, Daniel P. Poole et autres

Peripheral and central neurons in the pain pathway are well equipped to detect and respond to extracellular stimuli such as pro-inflammatory mediators and neurotransmitters through the cell surface expression of receptors that can mediate rapid intracellular signaling. Following injury or infection, activation …

au (code pays fourni par la source)