Jianing Yi

Potential therapeutic effects of Lactobacillus on Pancreatic ductal adenocarcinoma through its metabolite Harmaline

Wenjie Gao, Jianing Yi, Mingjie Meng, Chen Lu et autres

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal form of cancer. Recent research has uncovered the role of the gut microbiota in influencing PDAC progression and treatment outcomes. Dysbiosis of gut microbiota in PDAC patients has been shown to negatively …

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Nanopore long-read transcriptome sequencing reveals miR-22-3p-mediated transcriptomic remodeling and alternative splicing in chicken pectoral muscle

Jianing Yi, Jinyuan Chen, Jinjing Xu, Yingqiu Cai et autres

ABSTRACT The full-length transcriptomic architecture mediated by gga-miR-22-3p in poultry muscle development remains largely unexplored. To address this, a lentiviral knockdown vector targeting miR-22-3p was constructed, and an in vivo miR-22-3p knockdown model was established in the pectoral muscle of 14-day-old Qingyuan …

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Cascade‐Amplifying Immunophototherapy Nanoplatform Integrating Cocktail Drug Delivery

E Pang, Yuanyu Tang, Shaojing Zhao, Jianing Yi et autres

ABSTRACT Photodynamic therapy (PDT) offers the advantages of non‐invasiveness, non‐drug resistance, and high selectivity. However, its efficacy against melanoma is substantially limited by tumor hypoxia, elevated glutathione levels, and the strong antioxidant and light‐absorbing properties of melanin. Herein, we developed a cascade‐amplified …

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A multidimensional analysis of RAD1 as an immunological and prognostic biomarker in BRCA

J K Yu, Tiancheng Fan, Jianing Yi, Sihan Liu et autres

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Long-Read Transcriptome Sequencing and Alternative Splicing Analysis Reveal miR-22-3p-Mediated Regulatory Networks in Poultry Hearts

葉千華, Mengmeng Run, Huangbin Chu, Yingqiu Cai et autres

Synergistic antitumor therapy via immunophototherapy induced multi-modal cell death and immune microenvironment reprogramming

Xinyu Wang, Yunquan Yang, Shaojing Zhao, Yuanyu Tang et autres

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Kaempferol–Iron Assembled Nanoparticles for Synergistic Photothermal and Chemodynamic Therapy of Breast Cancer

Xiaochen Yang, Dan Tang, E Pang, Qi Yang et autres

Photothermal and chemodynamic therapies (PTT and CDT) have gained traction as viable adjunct anti-cancer treatments. However, they remain restricted by the low efficiency of photothermal conversion and the inefficiency of the Fenton reaction. Kaempferol (Kae), a naturally occurring bioactive flavonoid, can induce …

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TCEB2 promotes M2 polarization of macrophages in triple negative breast cancer by mediating ubiquitination degradation of Slit2 through recruiting NEDD4

Liu Li, Xiao Wang, Jie Zeng, Jianing Yi et autres

• M2 macrophage polarization was activated in TNBC, which might be connected to TCEB2 overexpression. • TCEB2 silencing inhibited TNBC cell proliferation, invasion, and their capacity to induce M2 macrophage polarization. • TCEB2 mediated Slit2 K63 ubiquitination degradation in TNBC by recruiting …

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Multimodal cascade-amplified phototheranostics for enhanced anti-tumor immunity

Liang Chen, Jierou Huang, Li Liu, Ming Tong et autres

Effective immuno-photodynamic therapy (IPDT) is impeded by the limitations of monotherapy approaches, inadequate immune activation, and an immunosuppressive tumor microenvironment (TME). Here, we present a multifunctional phototheranostic nanoplatform based on an A-D-A type photovoltaic molecule (ITCC), which self-assembles into water-soluble nanoparticles (ITCC …

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LncRNA CASC19 promotes the growth and glycolysis of colorectal cancer cells and tumor metastasis in mice

Xiao Zhang, Tingyu Zhao, Cheng Wu, Hengyang Shen et autres

It has been reported that lncRNA CASC19 is abnormally highly expressed in colorectal cancer (CRC) progression, suggesting that it may regulate the occurrence and metastasis of CRC, but its specific mechanism is still unclear. To further explore the effect of CASC19 on …

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Association between Noise Exposure and Hyperthyroidism Risk: A Retrospective Case-Control Study

Jianing Yi, Luyao Liu, Lin Xu

BACKGROUND: Environmental and lifestyle factors may influence hyperthyroidism prevalence. This research sought to explore the association between noise exposure and the risk of hyperthyroidism. METHODS: This retrospective case-control study was conducted in two hospitals in China between January 2022 and December 2023. …

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A multidimensional pan‐cancer analysis of NDUFA4L2 and verification of the oncogenic value in colon cancer

Jianing Yi, Wenjie Gao, Cheng Wu, Ranzhiqiang Yang et autres

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) protein is located in the mitochondria and can regulate cell proliferation. Some studies have shown that the high NDUFA4L2 expression is linked with poor prognosis and cancer progression in various patients with cancers. …

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